Application of Gold Nanoparticle-Based Materials in Cancer Therapy and Diagnostics

Vodyashkin, Andrey A.; Rizk, Marko George Halim; Kezimana, Parfait; Kirichuk, Anatoly A.; Stanishevskiy, Ya. M.

doi:10.3390/chemengineering5040069

Cited by 20 publications

(8 citation statements)

References 194 publications

(212 reference statements)

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“…Various authors have also created systems in which nano MOFs (NMOFs) can be successfully used as antibacterial agents, both as prophylactic or therapeutic agents, thus offering significant advantages in diagnosis, monitoring, and therapy. Therefore, in the following sections, given the highly cited potential biomedical applications of nanomaterials [7,8,43,114], we review the potential applications of MOFs.…”

Section: Biomedical Applications Of Mofsmentioning

confidence: 99%

“…Nanoparticles are a relatively new material in the medical field, but over the years they have become more and more relevant, since they have a very wide range of applications due to their different nature. Metal nanoparticles can be actively used as antibacterial, cytotoxic, and diagnostic materials [7][8][9][10]. Polymer nanoparticles can also be used as drug delivery systems to diagnose and treat various diseases [4,11].…”

Section: Introductionmentioning

confidence: 99%

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Metal-Organic Framework (MOF)—A Universal Material for Biomedicine

Vodyashkin

Sergorodceva

Kezimana

et al. 2023

IJMS

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Metal-organic frameworks (MOFs) are a very promising platform for applications in various industries. In recent years, a variety of methods have been developed for the preparation and modification of MOFs, providing a wide range of materials for different applications in life science. Despite the wide range of different MOFs in terms of properties/sizes/chemical nature, they have not found wide application in biomedical practices at present. In this review, we look at the main methods for the preparation of MOFs that can ensure biomedical applications. In addition, we also review the available options for tuning the key parameters, such as size, morphology, and porosity, which are crucial for the use of MOFs in biomedical systems. This review also analyses possible applications for MOFs of different natures. Their high porosity allows the use of MOFs as universal carriers for different therapeutic molecules in the human body. The wide range of chemical species involved in the synthesis of MOFs makes it possible to enhance targeting and prolongation, as well as to create delivery systems that are sensitive to various factors. In addition, we also highlight how injectable, oral, and even ocular delivery systems based on MOFs can be used. The possibility of using MOFs as therapeutic agents and sensitizers in photodynamic, photothermal, and sonodynamic therapy was also reviewed. MOFs have demonstrated high selectivity in various diagnostic systems, making them promising for future applications. The present review aims to systematize the main ways of modifying MOFs, as well as the biomedical applications of various systems based on MOFs.

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Section: Biomedical Applications Of Mofsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Metal-Organic Framework (MOF)—A Universal Material for Biomedicine

Vodyashkin

Sergorodceva

Kezimana

et al. 2023

IJMS

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“…Studies suggested that AuNPs less than 20 nm exhibited surface plasmon resonance (SPR) with negligible scattering characteristics [3,4]. In contrast, large AuNPs between 20 and 80 nm display increased scattering characteristics of these materials [5][6][7]. Many studies demonstrated the colloidal nature of spherical AuNPs, which appeared red with surface plasmon resonance (SPR) band observed at 520 nm, which depends on AuNP interparticle distance, surrounding media refractive index, shape, and size [8][9][10].…”

Section: Tunable Optical Propertiesmentioning

confidence: 99%

An Insight Into the Physicochemical Properties of Gold Nanoparticles in Relation to Their Clinical and Diagnostic Applications

Nukaly¹,

Ansari²

2023

Cureus

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The ease of formulation and surface modification of gold nanoparticles (AuNPs) by ligands, greater biocompatibility, non-cytotoxicity, and excellent optical properties are the characteristics that necessitate their application in clinical and genomic research. Not only that, but the extensive synthetic chemistry of AuNPs also offers precise control over physicochemical and optical properties owing to the inert, biocompatible, and non-toxic nature of the inner gold core. Another important property of AuNPs involves their incorporation into larger structures, including liposomes or polymeric materials, thereby increasing their capability of drug delivery in concurrent therapy and imaging labels for enhanced diagnostic applications. AuNPs are endowed with physical properties that suggest their use as adjuvants for radiotherapy and bio-imaging and in computed tomography (CT) scans, diagnostic systems, and therapy. Thus, these features strongly endorse the AuNPs in thrust areas of biomedical fields. The diverse properties of gold nanoparticles (AuNPs) have made them promising candidates in biomedical fields, including in the development of theranostics, which encompasses using these gold nanoparticles for both diagnosis and therapy simultaneously. To appreciate these and related applications, a need arises to review the basic principles and multifunctional attributes of AuNPs in relation to their advances in imaging, therapy, and diagnostics.

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“…Photoacoustic imaging (PAI)—a biomedical analysis technique that provides actionable information about the molecular characteristics of tissue—is a recently developed hybrid biomedical imaging technique for monitoring tumor angiogenesis and detecting skin melanoma, as well as for monitoring and diagnosing various other neoplasms [ 111 ].…”

Section: Main Applications Of Biodegradable Polymeric Nanoparticlesmentioning

confidence: 99%

Biopolymeric Nanoparticles–Multifunctional Materials of the Future

et al. 2022

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Nanotechnology plays an important role in biological research, especially in the development of delivery systems with lower toxicity and greater efficiency. These include not only metallic nanoparticles, but also biopolymeric nanoparticles. Biopolymeric nanoparticles (BPNs) are mainly developed for their provision of several advantages, such as biocompatibility, biodegradability, and minimal toxicity, in addition to the general advantages of nanoparticles. Therefore, given that biopolymers are biodegradable, natural, and environmentally friendly, they have attracted great attention due to their multiple applications in biomedicine, such as drug delivery, antibacterial activity, etc. This review on biopolymeric nanoparticles highlights their various synthesis methods, such as the ionic gelation method, nanoprecipitation method, and microemulsion method. In addition, the review also covers the applications of biodegradable polymeric nanoparticles in different areas—especially in the pharmaceutical, biomedical, and agricultural domains. In conclusion, the present review highlights recent advances in the synthesis and applications of biopolymeric nanoparticles and presents both fundamental and applied aspects that can be used for further development in the field of biopolymeric nanoparticles.

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Application of Gold Nanoparticle-Based Materials in Cancer Therapy and Diagnostics

Cited by 20 publications

References 194 publications

Metal-Organic Framework (MOF)—A Universal Material for Biomedicine

Metal-Organic Framework (MOF)—A Universal Material for Biomedicine

An Insight Into the Physicochemical Properties of Gold Nanoparticles in Relation to Their Clinical and Diagnostic Applications

Biopolymeric Nanoparticles–Multifunctional Materials of the Future

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