The non-neuronal cholinergic system in humans: Expression, function and pathophysiology

Wessler, Ignaz; Kilbinger, H.; Bittinger, Fernando; Unger, Ronald E.; Kirkpatrick, Charles James

doi:10.1016/s0024-3205(03)00083-3

Cited by 246 publications

(180 citation statements)

References 15 publications

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“…1-5, recently reviewed in Ref. 5) raised some interesting issues related to their specific activity. In humans, ACh and/or the synthesizing enzyme, choline acetyltransferase (ChAT), have been found in epithelial cells (airways, alimentary tract, urogenital tract, and epidermis), mesothelial (pleura and pericardium), endothelial, muscle and immune cells (mononuclear cells, granulocytes, alveolar macrophages, and mast cells).…”

Section: Introductionmentioning

confidence: 99%

α7-Nicotinic Acetylcholine Receptors Affect Growth Regulation of Human Mesothelioma Cells

et al. 2004

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Section: Introductionmentioning

confidence: 99%

α7-Nicotinic Acetylcholine Receptors Affect Growth Regulation of Human Mesothelioma Cells

et al. 2004

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“…Non-neuronal acetylcholine appears to be involved in the regulation of elementary cell functions such as cell mitosis, cell-cell interaction, cell automaticity, locomotion, ciliary activity, barrier function, resorption and secretion [29][30][31][32][33]. In the airways, for instance, the great majority of cells express the components of NNCS and it is documented that a substantial increase on ACh levels triggers the release of proinflammatory effectors [34].…”

Section: Non-neuronal Cholinergic System (Nncs)mentioning

confidence: 99%

The Ubiquity Nature of Acetylcholine

Saldanha

Silva-Herdade²

2014

Clin Exp Pharmacol

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“…Acetylcholine (ACh) is a phylogenetically ancient molecule, functioning as a local mediator as well as a neurotransmitter in almost all life-forms on earth [1]. ACh is also synthesized in plants, where it is likely involved in the transport of water, electrolytes and nutrients [2].…”

Section: Introductionmentioning

confidence: 99%

The combined effect of Cd2+ and ACh on action potentials of Nitellopsis obtusa cells

et al. 2009

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Abstract:Interrelations between the action of acetylcholine (ACh) and cadmium ions (Cd 2+ ) on bioelectrogenesis of Nitellopsis obtusa cells were investigated. We analyzed repetitively triggered action potentials (AP), their reproducibility, shape and dynamics of membrane potential after AP induction. ACh significantly increased membrane permeability only at high concentrations (1 mM and 5 mM). Repolarisation level of action potential after the first stimulus was much more positive in all cells treated with ACh as compared to the control. Differences of membrane potentials between points just before the first and the second stimuli were 23.4±.0 mV (control); 40.4±5.9 mV (1 mM ACh solution) and 57.7 ± 8.5 mV (5 mM ACh solution). Cd 2+ at 20 μM concentration was examined as a possible inhibitor of acetylcholinesterase (AChE) in vivo. We found that cadmium strengthens depolarizing effect of acetylcholine after the first stimulus. The highest velocity of AP repolarization was reduced after ACh application and Cd 2+ strengthened this effect. There were no differences in dynamics of membrane potential after repetitively triggered action potentials in ACh or ACh and Cd 2+ solutions. This shows that cadmium in small concentration acts as inhibitor of acetylcholinesterase.

show abstract

The non-neuronal cholinergic system in humans: Expression, function and pathophysiology

Cited by 246 publications

References 15 publications

α7-Nicotinic Acetylcholine Receptors Affect Growth Regulation of Human Mesothelioma Cells

α7-Nicotinic Acetylcholine Receptors Affect Growth Regulation of Human Mesothelioma Cells

The Ubiquity Nature of Acetylcholine

The combined effect of Cd2+ and ACh on action potentials of Nitellopsis obtusa cells

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