α7-Nicotinic Acetylcholine Receptors Affect Growth Regulation of Human Mesothelioma Cells

Abstract

ABSTRACT

Retracted: Tumor necrosis factor enhances SN38‐mediated apoptosis in mesothelioma cells

“…TNF administered simultaneously, as reported by different authors 33 and in our previous articles, 25,32 increased the level of DNA-SSB (under-deproiteinizing condition) induced by CPT. In MSTO-211H cells, SN38 (1-hour treatment at the IC 50 ) induced DNA breaks, as shown in Figure 2.…”

“…33 Briefly, adherent cells and detached cells were harvested separately, washed, and lysed with 50 mmol/L Tris, pH 7.5; 10 mmol/L EDTA; 0.5% Triton-X-100; and 0.5 mg/mL proteinase K for 2 hours at 50°C. Samples were then extracted twice with phenol/chloroform/ isoamyl alcohol and precipitated with ethanol.…”

Nicotine induces cell proliferation by -arrestin-mediated activation of Src and Rb-Raf-1 pathways

“…This contention is supported by the findings that nicotine can prevent apoptosis induced by various agents, thus conferring a survival advantage as well (10,(50)(51)(52). Elucidation of the signaling events mediated by nAChRs present on nonneuronal cells may open new avenues for targeting cancer therapy, focusing on agents that inhibit the β-arrestin-Src signaling axis or Rb-Raf-1 interaction.…”

Agmatine Ameliorates Nicotine Induced Lung Injury in Rats through Decrease TGF-ß1 and Bax Immunoexpression and by Anti-oxidative Sress Pathway: Histological, Immunohistochemical and Biochemical Study

“…El-Sokkary et al [2] reported that the lung is the chief organ which is highly liable to free radical generation after cigarette smoke. Also, Trombino et al [47] and Luqman and Rizvi [48] observed interstitial infiltration of inflammatory cells, degenerative changes of both and alveolar epithelium and interstitial cells in addition to interstitial infiltration of inflammatory. These changes could be explained by chronic inflammation caused by NIC administration [49].…”