The paper is devoted to experimental justification of widespread application of individualization in choosing types and volumes of physical activity for physical education classes taking into account typological indicators. The purpose of the study was to improve the physical education of schoolchildren by developing the concept of individual-typological approach to assessing the regulation of functional systems of the body for the educational process management. Materials and methods: theoretical review of the current scientific literature on the issues allowed forming the methodology of the experimental study. The computer program Express Assessment of Physical Health (FH) and Development (FD) of Schoolchildren was used as diagnostic methods, alongside with the measurement of Quetelet, Robinson, Skibinsky, Shapovalova, Ruffier indices. In order to assess the efficiency of FE classes in the main group (MG) (experimental) and comparison group (CG) (control), heart rate variability (HRV) indicators were detected through electrocardiogram characteristics (ECG) using Varikard 2.51 hardware and software complex. The system of selection of loads at physical education classes based on typological indicators of regulation of muscular and cardio-respiratory systems was developed and tested. Mathematical and statistical processing of data was carried out by means of λ-Kolmogorsk-Smirnov one-sample test, χ 2 Pearson's parametric criterion and k-means clustering (Euclidean distance). The results of the study showed the efficiency of using individual health set of exercises to minimize functional deviations of body systems according to PD and HRV.