The new low-osmolar contrast media: A simple guide

Dawson, Peter; Grainger, Ronald G.; Pitfield, Jean

doi:10.1016/s0009-9260(83)80312-2

Cited by 92 publications

(18 citation statements)

References 12 publications

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“…37,39 Transmetallation results in Gd 3+ exchange with another ion such as Ca 2+ within the chelate complex. As Gd 3+ has approximately the same size as Ca 2+ , free Gd 3+ can block calcium channels in the cell membrane.…”

Section: Cell Proliferation and Viabilitymentioning

confidence: 99%

Diamagnetically trapped arrays of living cells above micromagnets

et al. 2011

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Cell arrays are of foremost importance for many applications in pharmaceutical research or fundamental biology. Although arraying techniques have been widely investigated for adherent cells, organization of cells in suspension has been rarely considered. The arraying of non-adherent cells using the diamagnetic repulsive force is presented. A planar arrangement of Jurkat cells is achieved at the microscale above high quality microfabricated permanent magnets with remanent magnetization of J(r)≈ 1 T, in the presence of a paramagnetic contrast agent. The cytotoxicity of three Gd based contrast agents, Gd-DOTA, Gd-BOPTA and Gd-HP-DO3A, is studied. Among them, Gd-HP-DO3A appears to be the most biocompatible toward Jurkat cells. In close agreement with analytical simulations, diamagnetically 'suspended' cells have been successfully arrayed above square and honeycomb-like micromagnet arrays, which act as a "diamagnetophobic" surface. Living cell trapping is achieved in a simple manner using concentrations of Gd-HP-DO3A as low as 1.5 mM.

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Section: Cell Proliferation and Viabilitymentioning

confidence: 99%

Diamagnetically trapped arrays of living cells above micromagnets

et al. 2011

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“…Hexabrix is a mono acid dimer salt of a mixture of sodium and meglumine ioxaglate with six iodine atoms in the ioxaglate radical [16]. Hexabrix 320 diluted with an equal volume of water has an osmolality approximately equal to that of plasma, (ca.…”

Section: Contrast Mediamentioning

confidence: 99%

“…300 mosmol/kg). Niopam and Omnipaque are non-ionic compounds each with three iodine atoms per molecule [16]. Both Niopam 200 and Omnipaque 180 are slightly hypertonic compared with plasma.…”

Section: Contrast Mediamentioning

confidence: 99%

The use of low osmolality water soluble (LOWS) contrast media in the pediatric gastro-intestinal tract

Ratcliffe¹

1986

Pediatr Radiol

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There are dangers in the use of either barium sulphate suspensions or the conventional hypertonic water soluble contrast media in the gastrointestinal tract of "at risk" babies and children. These dangers can be avoided by the use of low osmolality water soluble (LOWS) contrast media. This paper reports the satisfactory use of three such contrast media, ioxaglate (Hexabrix), iohexol (Omnipaque) and iopamidol (Niopam) in 115 examinations of the gastrointestinal tracts of 89 babies and children. Morbidity from the inhalation or extravasation of contrast medium was negligible. It is proposed that LOWS contrast media should be used more widely in the gastro-intestinal investigation of all "at risk" babies and children.

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“…Low-esmolality agents have been formulated as a possible means of reducing the frequency of these adverse reactions [4,5]. This study was designed to assess the extent to which these new agents influenced the frequency and/or nature of patients' subjective reactions to IV contrast injections.…”

Section: Lowmentioning

confidence: 99%