The Natural History of Polymethylmethacrylate Microspheres Granulomas

Gelfer, Allison; Carruthers, Alastair; Carruthers, Jean; Jang, Frances; Bernstein, Steven

doi:10.1097/00042728-200705000-00014

Cited by 16 publications

(22 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is critical that patients be informed of the potential problems with PMMA microspheres and of the need for prolonged follow-up. The most significant complication following polymethylmethacrylate microsphere implantation is granuloma formation [17]. Additional studies should be conducted to determine the safety of polymethylmethacrylate microsphere injection, reduce the occurrence of adverse reactions, and identify risk factors that are associated with higher complication rates.…”

Section: Discussionmentioning

confidence: 99%

Clinical Experience with Polymethylmethacrylate Microsphere Filler Complications

et al. 2011

View full text Add to dashboard Cite

Polymethylmethacrylate (PMMA) filler is widely used for the correction of wrinkles because of its relative long-lasting cosmetic improvements and the rarity of reported complications. However, early and delayed complications, ranging from minor to severe, can occur following PMMA filler injection. We evaluated and treated 13 cases of PMMA filler-related complications that were referred to our institution from July 2005 to June 2010. Of these patients, 92.3% were female and 7.7% were male. Complications were roughly classified as (1) nodular masses, (2) inflammation, (3) allergic reactions, and (4) discoloration. Affected locations were the lips, periocular wrinkles, nasolabial folds, forehead, marionette wrinkles, and cheeks. As there is no standard treatment modality for PMMA filler complications, patients were managed with various treatments aimed at minimizing morbidity. In the cases of lip granuloma, we recommended intralesional steroid injection first, followed by surgical excision, including lip mucosa and orbicularis oris muscle in intractable cases. Additional studies should be conducted to determine the safety of PMMA injection, reduce the occurrence of adverse reactions, and identify risk factors that are associated with higher complication rates.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical Experience with Polymethylmethacrylate Microsphere Filler Complications

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Amongst those, only 0,01% developed granuloma formation. 74,75 Brazil is one of the countries with the largest experience with the use of PMMA for cutaneous filling. Although very satisfactory results have been achieved on the treatment of FL with the PMMA implant, there are still few scientific papers on the issue.…”

Section: Polymethilmethacrylatementioning

confidence: 99%

Lipoatrofia facial associada ao HIV/AIDS: do advento aosconhecimentos atuais

Soares¹,

Costa

2011

An. Bras. Dermatol.

View full text Add to dashboard Cite

Abstract:The advent of AIDS has brought new challenges to Dermatology. Antiretroviral therapy dramatically changed the morbidity and mortality associated with HIV / AIDS, but contributed to the emergence of other new situations that require adequate approach by the dermatologist. The HIV / AIDS Associated Lipodystrophy Syndrome is multifactorial in origin, but it is strongly associated with the use of antiretroviral drugs. It includes changes in body fat distribution, with or without metabolic changes. The loss of facial fat, called facial lipoatrophy, is one of the most stigmatizing signs of the syndrome. This condition, often revealing of the disease, brought back the stigma of AIDS. It is necessary that the specialists working with patients with HIV / AIDS identify these changes and seek treatment options, amongst which stands out the implant with polymethylmethacrylate, which is available for the treatment of HIV / AIDS facial lipoatrophy in the Brazilian Public Health System. Keywords: Ambulatory surgical procedures; HIV; HIV-associated lipodystrophy syndrome; Polymethyl methacrylate; Therapeutics Resumo: O advento da AIDS trouxe novos desafios para a Dermatologia. A terapia antirretroviral mudou drasticamente a morbimortalidade associada à infecção pelo HIV/AIDS, mas contribuiu para o surgimento de outras novas situações que exigem abordagem adequada do dermatologista. A Síndrome Lipodistrófica Associada ao HIV/AIDS tem origem multifatorial, mas está fortemente associada ao uso dos antirretrovirais. Compreende alterações na distribuição da gordura corporal, acompanhada ou não de alterações metabólicas. A perda da gordura da face, chamada lipoatrofia facial, é dos sinais mais estigmatizantes da síndrome. Esta condição, muitas vezes reveladora da doença, trouxe de volta o estigma da AIDS. É necessário que os especialistas que atuam com pacientes com HIV/AIDS identifiquem estas alterações e busquem opções de tratamento, dentre as quais se destaca o implante com polimetilmetacrilato, que é disponibilizado para tratamento da lipoatrofia facial associada ao HIV/AIDS no Sistema Único de Saúde.

show abstract

“…They present suddenly with rapid onset of symptoms, including induration, swelling, discoloration and tenderness. Often, all injected areas will react simultaneously [91]. Immunotherapy may also induce granulomas of hitherto well-tolerated Artecoll injections [37].…”

Section: Risks Of Permanent Fillersmentioning

confidence: 99%

Risks of permanent fillers

Haneke¹

2009

Expert Review of Dermatology

View full text Add to dashboard Cite

The Natural History of Polymethylmethacrylate Microspheres Granulomas

Cited by 16 publications

References 5 publications

Clinical Experience with Polymethylmethacrylate Microsphere Filler Complications

Clinical Experience with Polymethylmethacrylate Microsphere Filler Complications

Lipoatrofia facial associada ao HIV/AIDS: do advento aosconhecimentos atuais

Risks of permanent fillers

Contact Info

Product

Resources

About