Risks of permanent fillers

Haneke, Eckart

doi:10.1586/edm.09.19

Cited by 7 publications

(8 citation statements)

References 83 publications

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“…Polyacrylamide gel (PAAG) is a suspension of 2.5%–5% PAAG in sterile water. It is produced in different countries and marketed under many various names: PAAG (Sinocos Eastcos, Hong Kong, China), Amazing gel, Aqualift, Aquamid, (Contura International, Söborg, Danmark), Argiform, Bioformacryl, Formacryl, and Outline, which are slightly different in minute additional components (Haneke, ). The material is widely resistant to enzymatic degradation and phagocytosis.…”

Section: Soft Tissue Fillersmentioning

confidence: 99%

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Adverse effects of fillers

Haneke

2018

Dermatologic Therapy

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Filler injections belong to the most frequently performed noninvasive beautifying procedures. When done correctly they are generally well tolerated. However, a number of factors, such as poor filler quality, and particularly host as well as user dependent filler reactions may lead to unwanted effects. These may be early, late, or delayed events with characteristics for each of them. Temporary fillers almost invariably cause temporary side effects whereas those of permanent fillers may last forever. Some fillers are notorious for their poor safety profile; for example, silicone is banned in the European Union and the United States but nevertheless used by many practitioners and beauticians. Many fillers can be identified in histopathologic sections allowing specific measures to be instituted.

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Section: Soft Tissue Fillersmentioning

confidence: 99%

“…Filler adverse effects are classified according to their time course and whether they are user dependent, due to the filler itself or host factors (Haneke, , ). Technical errors concern too much or too little volume, incorrect depth of filler placement, wrong location, and inappropriate product choice (DeLorenzi, ).…”

Section: Introductionmentioning

confidence: 99%

Adverse effects of fillers

Haneke

2018

Dermatologic Therapy

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“…It is marketed under many different names: PAAG (Sinocos Eastcos, Hong Kong, China), Amazing gel, Aqualift, Aquamid (Contura International, Søborg, Denmark), Argiform, Bioformacryl, Formacryl, and Outline, which are slightly different in minute additional components. 1 The material is widely resistant to enzymatic degradation and phagocytosis. The particles can harbor bacteria on their surface and give rise to late infections, biofilms, and abscesses.…”

Section: Polyacrylamide Gelmentioning

confidence: 99%

“…Despite initial satisfying results, long-term results were usually appalling because of skin hardening, swelling, granuloma formation, ulceration and fistulation, infections, abscesses, and even cancer development. 1 Paraffin is irreversible and no longer legally used as a filler although highly inflammatory granulomas after fraudulent use of paraffin or other oils containing vitamin E, sometimes also vitamins D and A, are still seen (►Fig. 14).…”

Section: Paraffin and Other Mineral Oil And Lipid Derivativesmentioning

confidence: 99%

“…Filler adverse effects can be classified according to their time course and because of user dependent, filler and host factors. 1,2 Technical errors concern too much or too little volume, incorrect depth of filler placement, wrong location, and inappropriate product choice. 3 The physician injecting the filler must, of course, be experienced to avoid gross mistakes concerning the site of injection, the volume, the speed, the depth, etc., as well as the postinjection treatment.…”

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Adverse Effects of Fillers and Their Histopathology

Haneke

2014

Facial plast Surg

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Injectable fillers nowadays represent a pillar in facial rejuvenation and make a significant contribution to the success of the treatment. Despite their obvious benefits, a wide range of possible complications such as immediate, late, delayed, temporary, or irreversible adverse effects have to be respected. Differentiating the various filler materials, these effects are assigned to histopathology findings and currently available treatment options.

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Permanent fillers—What is their role

Chan

Schlesinger³

2023

Dermatological Reviews

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Background: With the growing cosmetic industry, there have been numerous advancements in nonsurgical interventions including the use of permanent dermal filler injections. Permanent fillers are relatively novel in clinical use when compared to temporary and semi-permanent fillers. The only FDA-approved, non-biodegradable permanent filler uses polymethylmethacrylate (PMMA) microspheres. PMMA is suspended in bovine collagen and lidocaine solution for injection, absorbed by the body, and replaced overtime by collagen. ArteFill® was the first FDA approved permanent filler in 2005 for correction of nasolabial folds, with studies demonstrating rejuvenation for up to five years, trumping its predecessors in longevity. A decade later with rebranding, Bellafill® was indicated for correction of nasolabial fold and atrophic acne scars. Aims: To review the development of permanent fillers, mechanism, and safety. Materials & Methods: A qualitative systematic review was conducted on PMMA microspheres indications, contraindications, and off-label use on benefits, risks, and adverse events.Results: The durability of permanent fillers has a strong appeal for both patients and practitioners, however, usage for certain patient populations demonstrates increased risk for both early and late complications compared to temporary and semi-permanent fillers. A skin test composed of purified 3.5% bovine collagen gel administered in the volar forearm is recommended one month prior to injection, to identify any patients who may have a positive response. Bovine collagen demonstrates low immunogenicity with the incidence of preexisting hypersensitivity reported to be between 2-4%. Bovine collagen in dermatologic formulations use pepsin-solubilized formulations in which telopeptides are cleaved to further help reduce aberrant immunogenic responses.Discussion: Early and late complications may outweigh the benefits in use of permanent fillers, however these complications are patient dependent. Conclusion:Permanent fillers may be useful in volume replacement for nasolabial folds and atrophic acne scars, however a provider must use good clinical judgement in deciding which patients are ideal candidates.

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Risks of permanent fillers

Cited by 7 publications

References 83 publications

Adverse effects of fillers

Adverse effects of fillers

Adverse Effects of Fillers and Their Histopathology

Permanent fillers—What is their role

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