The National Institutes of Health’s Biomedical Translational Research Information System (BTRIS): Design, contents, functionality and experience to date

Abstract

The US National Institutes of Health (NIH) has developed the Biomedical Translational Research Information System (BTRIS) to support researchers’ access to translational and clinical data. BTRIS includes a data repository, a set of programs for loading data from NIH electronic health records and research data management systems, an ontology for coding the disparate data with a single terminology, and a set of user interface tools that provide access to identified data from individual research studies and data across all studies from which individually identifiable data have been removed. This paper reports on unique design elements of the system, progress to date and user experience after five years of development and operation.

Modern Approaches to the Organization of Translational Research

“…The US National Institutes of Health established the Biomedical Translational Research Information System (BTRIS). It contains the information obtained not only through clinical practice, but also by means of experiments and clinical studies, and allows planning and performing translational, prospective and retrospective studies on the basis of the available data [26]. The establishments that are focused primarily on stage T2 ought to analyze and demonstrate effectiveness of the developed treatment strategies, which appeared efficient at T1 on the population level [27].…”

Complete blood count with differential: An effective diagnostic for IBS subtype in the context of BMI?

“…CBC-D data was compiled and curated from the NIH CRC Biomedical Translational Research Information System (BTRIS) [30] and Clinical Research Information System (CRIS) databases (https://cris.cc.nih.gov/index.html). CBC data provides absolute counts by volume for overall WBCs, and absolute and relative counts for monocytes, lymphocytes, neutrophils, and eosinophils.…”

Pharmacogenomics Implementation at the National Institutes of Health Clinical Center

“…Ordering The NIH CC uses Allscripts Sunrise Clinical Manager 15.3 as the central component of the electronic health record, referred to as the Clinical Research Information System (CRIS). 5,6 With guidance from the PG Subcommittee, a pharmacogenomics CDS program that is completely integrated into the natural medication order pathway was implemented within the electronic health record. 7 The current program is based on our previous experience with iADRs corresponding to abacavir, allopurinol, and carbamazepine therapies, as discussed in Goldspiel et al 8 We have recently expanded this program to include genotyping drug-metabolizing and -transporting (DMET) genes, using the Affymetrix DMET Plus array that tests 1936 genetic variants in 235 pharmacogenes.…”