The Multifaceted Role of Long Non-Coding RNA in Gastric Cancer: Current Status and Future Perspectives

Li, Yifan; Lü, Lei; Wu, Xu; Li, Qianxiu; Zhao, Yueshui; Du, Fukuan; Chen, Yu; Shen, Jing; Xiao, Zhangang; Wu, Zhigui; Hu, Wei; Cho, Chi Hin; Li, Mingxing

doi:10.7150/ijbs.61410

Cited by 22 publications

(14 citation statements)

References 142 publications

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“…For instance, targeting specific GC-related lncRNAs can effectively reverse drug resistance and enhance the sensitivity of GC cells to chemotherapeutic drugs. 24 N6-methyladenosine (m 6 A)-related lncRNAs have been shown to remodel tumor microenvironment and alter immune checkpoint blockers sensitivity, indicating the great potential of m 6 A-related lncRNA as an indicator for the response to immunotherapy in GC. 25 Although great progress has been made in investigating the role of lncRNAs in GC, more studies are still required to further elucidate their detailed mechanisms in GC progression, thereby providing novel insights into the application of lncRNAs in GC clinical treatment.…”

Section: Introductionmentioning

confidence: 99%

Long non-coding RNAs: Biogenesis, functions, and clinical significance in gastric cancer

Liu

Ding

et al. 2021

Molecular Therapy - Oncolytics

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Gastric cancer (GC) is one of the most prevalent malignant tumor types and the third leading cause of cancer-related death worldwide. Its morbidity and mortality are very high due to a lack of understanding about its pathogenesis and the slow development of novel therapeutic strategies. Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs with a length of more than 200 nt. They play crucial roles in a wide spectrum of physiological and pathological processes by regulating the expression of genes involved in proliferation, differentiation, apoptosis, cell cycle, invasion, metastasis, DNA damage, and carcinogenesis. The aberrant expression of lncRNAs has been found in various cancer types. A growing amount of evidence demonstrates that lncRNAs are involved in many aspects of GC pathogenesis, including its occurrence, metastasis, and recurrence, indicating their potential role as novel biomarkers in the diagnosis, prognosis, and therapeutic targets of GC. This review systematically summarizes the biogenesis, biological properties, and functions of lncRNAs and highlights their critical role and clinical significance in GC. This information may contribute to the development of better diagnostics and treatments for GC.

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Section: Introductionmentioning

confidence: 99%

Long non-coding RNAs: Biogenesis, functions, and clinical significance in gastric cancer

Liu

Ding

et al. 2021

Molecular Therapy - Oncolytics

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“…LncRNAs are key regulators in the pathophysiology of gastric cancer, and lncRNAs have been regarded as potential biomarkers and therapeutic targets for gastric cancer ( 24 ). With the great advancement in high-throughput technologies, bioinformatic exploration has enabled us to efficiently identify novel lncRNAs associated with cancer progression.…”

Section: Discussionmentioning

confidence: 99%

Revealing the Role of lncRNA CCDC144NL-AS1 and LINC01614 in Gastric Cancer via Integrative Bioinformatics Analysis and Experimental Validation

et al. 2022

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Long non-coding RNAs (lncRNAs) are key regulators in the pathophysiology of gastric cancer, and lncRNAs have been regarded as potential biomarkers and therapeutic targets for gastric cancer. The present study performed the WGCNA analysis of the GSE70880 dataset and aimed to identify novel lncRNAs associated with gastric cancer progression. Based on the WGCNA, the lncRNAs and mRNA co-expression network were constructed. A total of four modules were identified and the eigengenes in different modules were involved in various key signaling pathways. Furthermore, the co-expression networks were constructed between the lncRNAs and mRNA; this leads to the identification of 6 modules, which participated in various cellular pathways. The survival analysis showed that high expression of CCDC144NL antisense RNA 1 (CCDC144NL-AS1) and LINC01614 was positively correlated with the poor prognosis of patients with gastric cancer. The in vitro validation results showed that CCDC144NL-AS1 and LINC01614 were both up-regulated in the gastric cancer cells. Silence of CCDC144NL-AS1 and LINC01614 both significantly suppressed the cell proliferation and migration of gastric cancer cells, and also promoted the chemosensitivity of gastric cancer cells to 5-fluorouracil. Collectively, our results suggested that the newly identified two lncRNAs (CCDC144NL-AS1 and LINC01614) may act as oncogenes in gastric cancer.

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“…GC is thought to be caused by the interaction of host genetic factors and complex environmental factors, and the importance of local tumor-host cell interactions in cancer biology is increasingly recognized 23 . Importantly, SULF2 is at the interface between the cancer cell and the tumor microenvironment.…”

Section: Discussionmentioning

confidence: 99%

SULF2 Is a Prognostic Biomarker and Correlated with Tumor Associated Macrophages in Gastric Cancer

Wang

Zhang

et al. 2021

Preprint

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Background: Recently, the mutual effects of tumor cells and the tumor immune microenvironment have been identified as key factors in promoting cancer progression. Sulfatase 2 (SULF2) encodes an extracellular endoglucosamine‑6-sulfatase, which could remodel the highly sulfated domains of heparan sulfate. The abnormal expression of SULF2 is reported to play an important role in the carcinogenesis of many kinds of cancer. However, the prognostic value of SULF2 and its correlation with immune cell infiltration in gastric cancer (GC) remain unclear. Results: SULF2 expression was significantly increased in GC compared with gastric normal tissue, especially in the advanced stage GC. In addition, high SULF2 expression significantly predicted an unfavorable prognosis in GC patients (overall survival P=0.0074), particularly who had metastatic lymph nodes. Besides, pathway analyses of SULF2 in GC revealed SULF2 may take part in extracellular structure organization, cell-cell adhesion and proteoglycans in cancer, etc. Importantly, the expression level of SULF2 was found to be positively correlated with the infiltration levels of tumor associated macrophages (TAMs). Moreover, SULF2 expression in GC positively correlated with expression of several immune cell markers, including monocyte markers, TAMs markers and programmed cell death 1 ligand 1 (PD-L1), suggesting its role in regulating tumor immunity.Conclusion: This study identified distinct expression and prognostic values of SULF2 in GC using public databases. Significantly, our findings shed light on the role of SULF2 in GC progression and provided an underlying mechanism that SULF2 expression might modulate tumor immunity by regulating the infiltration of TAMs in GC.

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The Multifaceted Role of Long Non-Coding RNA in Gastric Cancer: Current Status and Future Perspectives

Cited by 22 publications

References 142 publications

Long non-coding RNAs: Biogenesis, functions, and clinical significance in gastric cancer

Long non-coding RNAs: Biogenesis, functions, and clinical significance in gastric cancer

Revealing the Role of lncRNA CCDC144NL-AS1 and LINC01614 in Gastric Cancer via Integrative Bioinformatics Analysis and Experimental Validation

SULF2 Is a Prognostic Biomarker and Correlated with Tumor Associated Macrophages in Gastric Cancer

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