Long non-coding RNAs: Biogenesis, functions, and clinical significance in gastric cancer

Liu, Ying; Ding, Wei; Yu, Wanpeng; Zhang, Yuan; Ao, Xiang; Wang, Jianxun

doi:10.1016/j.omto.2021.11.005

Cited by 78 publications

(47 citation statements)

References 187 publications

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“…The expression of lncRNA is tightly regulated, and its expression patterns exhibit temporal and spatial specificity [ 31 ]. Dysregulated lncRNAs are considered to be a useful metric for characterizing the molecular profile of GC, affecting patients' prognosis through multiple molecular pathways [ 32 , 33 ]. Therefore, exploring dysregulated molecular signatures that are upregulated or downregulated in GC would be available for diagnosis, treatment, and prognosis [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Upregulated LINC00922 Promotes Epithelial-Mesenchymal Transition and Indicates a Dismal Prognosis in Gastric Cancer

Chen

Mao

et al. 2022

Journal of Oncology

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Background. LINC00922 has been found to promote epithelial-mesenchymal transition (EMT) in a variety of tumors. But its functions in gastric cancer (GC) remain unclear. We attempt to investigate the correlation between LINC00922 and GC via bioinformatics analysis, in vitro and in vivo experiments. Methods. TCGA and GTEx databases were utilized to obtain the RNAseq and clinical data of GC, and then, identified the correlation of LINC00922 with patients’ clinicopathological characteristics and prognosis. GSEA and GO/KEGG enrichment analyses were performed to explore the potential functions or signaling pathways that LINC00922 participated in GC. Infiltration levels of immune cells were employed by ssGSEA algorithm, and then Wilcoxon rank sum test was applied to analyze their correlations with LINC00922. Scratch and transwell assays were conducted to detect the invasion and migration abilities of GC cells. Western blot was performed to explore the expression level of EMT-related proteins. Furthermore, we constructed the xenograft tumor model and metastatic tumor model in nude mice to explore the effect of LINC00922 downregulating on metastasis of GC cells in vivo. Results. Compared with normal tissues, LINC00922 was highly expressed in GC tissues and positively correlated with poor prognosis. The correlation existed between LINC00922 and immune infiltration in GC. Downregulation of LINC00922 inhibited the EMT process of GC cells. In addition, both in vitro and in vivo experiments showed that LINC00922 affects the invasion and migration abilities of GC. Conclusions. LINC00922 promotes the migration, invasion, and EMT in GC and has the potential to be used as a prognostic biomarker and therapeutic target for GC.

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Section: Discussionmentioning

confidence: 99%

Upregulated LINC00922 Promotes Epithelial-Mesenchymal Transition and Indicates a Dismal Prognosis in Gastric Cancer

Chen

Mao

et al. 2022

Journal of Oncology

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“…Long non-coding RNAs (lncRNAs) are a large class of endogenous ncRNAs with a length of more than 200 nucleotides (7). In recent years, with the rapid development of bioinformatics analysis and the application of high-throughput sequencing technologies, a large number of lncRNAs has been found to occur widely and stably in eukaryotes, including those of plant, animal, and human being (8,9). They are involved in various biological processes, such as proliferation, apoptosis, invasion, and metastasis, by regulating the timing and degree of gene expression via multiple mechanisms, including signal, decoy, scaffold, guide, and SINEUPs (9).…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, with the rapid development of bioinformatics analysis and the application of high-throughput sequencing technologies, a large number of lncRNAs has been found to occur widely and stably in eukaryotes, including those of plant, animal, and human being (8,9). They are involved in various biological processes, such as proliferation, apoptosis, invasion, and metastasis, by regulating the timing and degree of gene expression via multiple mechanisms, including signal, decoy, scaffold, guide, and SINEUPs (9). In addition, lncRNAs also play crucial roles in the regulation of multiple pathological and physiological processes, such as embryonic development, gene expression regulation, and carcinogenesis, by acting as a competing endogenous RNA (ceRNA) to modulate the expression of specific microRNAs (miRNAs), thereby targeting the downstream genes of these miRNAs (10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Long Non-Coding RNA in Gastric Cancer: Mechanisms and Clinical Implications for Drug Resistance

Liu

Yü

et al. 2022

Front. Oncol.

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Gastric cancer (GC) is the third leading cause of cancer-related deaths worldwide, with high recurrence and mortality rate. Chemotherapy, including 5-fluorouracil (5-FU), adriamycin (ADR), vincristine (VCR), paclitaxel (PTX), and platinum drugs, remains one of the fundamental methods of GC treatment and has efficiently improved patients’ prognosis. However, most patients eventually develop resistance to chemotherapeutic agents, leading to the failure of clinical treatment and patients’ death. Recent studies suggest that long non-coding RNAs (lncRNAs) are involved in the drug resistance of GC by modulating the expression of drug resistance-related genes via sponging microRNAs (miRNAs). Moreover, lncRNAs also play crucial roles in GC drug resistance via a variety of mechanisms, such as the regulation of the oncogenic signaling pathways, inhibition of apoptosis, induction of autophagy, modulation of cancer stem cells (CSCs), and promotion of the epithelial-to-mesenchymal transition (EMT) process. Some of lncRNAs exhibit great potential as diagnostic and prognostic biomarkers, as well as therapeutic targets for GC patients. Therefore, understanding the role of lncRNAs and their mechanisms in GC drug resistance may provide us with novel insights for developing strategies for individual diagnosis and therapy. In this review, we summarize the recent findings on the mechanisms underlying GC drug resistance regulated by lncRNAs. We also discuss the potential clinical applications of lncRNAs as biomarkers and therapeutic targets in GC.

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“…Short ncRNAs, such as microRNAs (miRNAs), and piwi-interacting RNAs, are ncRNAs 19–25 nucleotides long which control gene expression that affects the target mRNAs or suppresses translation [ 2 , 3 , 4 ]. Long ncRNAs (lncRNAs) can be detected by longer sequences and are broadly present in eukaryotic cells, with from about 5400 to more than 10,000 lncRNA transcripts in the human genome [ 5 ]. Finally, circRNAs are RNA molecules covalently closed without 5′ or 3′ ends and a poly-A tail and have fundamental effects in physiology and in several pathologic conditions.…”

Section: Introductionmentioning

confidence: 99%

Circular RNA as a Novel Biomarker for Diagnosis and Prognosis and Potential Therapeutic Targets in Multiple Myeloma

Allegra

Cicero

Tonacci

et al. 2022

Cancers

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Circular RNAs (circRNAs) are a novel type of covalently closed RNAs involved in several physiological and pathological processes. They display tissue-specific expression and are constant, abundant, and highly conserved, making them perfect markers for diagnosis and prognosis. Several studies have proposed that circRNAs are also differentially produced in malignancies where they have oncogenic effects. Furthermore, circRNAs affecting microRNAs modify the expression profile of several transcription factors which play essential roles in tumors. CircRNAs within the hematopoietic compartment were identified as modulators of mechanisms able to enhance or suppress tumor progression in blood malignancies. Moreover, several circRNAs were suggested to confer resistance to the conventional drugs employed in hematopoietic cancers. In this review, we highlight the growing role and the controlling mechanisms by which circRNAs modify multiple myeloma genesis. We propose that circRNAs can be considered as potential diagnostic and prognostic markers, can induce chemoresistance, and might represent novel therapeutic targets for multiple myeloma.

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Long non-coding RNAs: Biogenesis, functions, and clinical significance in gastric cancer

Cited by 78 publications

References 187 publications

Upregulated LINC00922 Promotes Epithelial-Mesenchymal Transition and Indicates a Dismal Prognosis in Gastric Cancer

Upregulated LINC00922 Promotes Epithelial-Mesenchymal Transition and Indicates a Dismal Prognosis in Gastric Cancer

Long Non-Coding RNA in Gastric Cancer: Mechanisms and Clinical Implications for Drug Resistance

Circular RNA as a Novel Biomarker for Diagnosis and Prognosis and Potential Therapeutic Targets in Multiple Myeloma

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