The MTHFR C677T Polymorphism and Risk of Acute Lymphoblastic Leukemia: an Updated Meta-analysis Based on 37 Case-control Studies

Jiang, Yuan; Hou, Jing; Zhang, Qiang; Jia, Shuting; Wang, Bo-Yuan; Zhang, Jihong; Tang, Wenru; Luo, Ying

doi:10.7314/apjcp.2013.14.11.6357

Cited by 23 publications

(16 citation statements)

References 46 publications

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“…Hematologic malignancies are a common disease in Asian Pacific areas (Feng et al, 2013;Jiang et al, 2013;Karami et al, 2013;Khodabandehloo et al, 2013;Kooshyar et al, 2013;Li et al, 2013;Liu et al, 2013;Ozbas-Gerceker et al, 2013;Qin et al, 2013;Shan et al, 2013). As our present study confirmed, the level of serum ferritin of patients with hematologic malignancies was significantly increased.…”

Section: Discussionsupporting

confidence: 78%

Elevated Serum Ferritin Levels in Patients with Hematologic Malignancies

Zhang

Su²,

Hu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 78%

Elevated Serum Ferritin Levels in Patients with Hematologic Malignancies

Zhang

Su²,

Hu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Incidence of ALL declines with age nonetheless, its prognosis in adults has always been inferior to children (Faderl et al, 2010;Jinnai et al, 2010). Several age dependent biological and host factors have been described (Jiang et al, 2013;Wang et al, 2014) including, differences in sensitivities of leukemic cells to corticosteroids, metabolism of chemotherapy (Kaspers et al, 1995), depleted marrow reserve and increased extramedullary toxicity (Mishra et al, 2006;Ribera and Oriol, 2009). However, the most important differences lie in cytogenetic and molecular characteristics.…”

Section: Introductionmentioning

confidence: 99%

Frequency of Chromosomal Abnormalities in Pakistani Adults with Acute Lymphoblastic Leukemia

Shaikh

Adil²,

Shaikh³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: The difference in prognosis of adult and childhood acute lymphoblastic leukemia (ALL) can be attributed largely to variation in cytogenetic abnormalities with age groups. Cytogenetic analysis in acute leukemia is now routinely used to assist patient management, particularly in terms of diagnosis, disease monitoring, prognosis and risk stratification. Knowing about cytogenetic profile at the time of diagnosis is important in order to take critical decisions in management of the patients. Aim and Objectives: To determine the frequency of cytogenetic abnormalities in Pakistani adult patients with ALL in order to have insights regarding behavior of the disease. Materials and Methods: A retrospective analysis of all the cases of ALL (≥15years old) diagnosed at Aga Khan University from January 2006 to June 2014 was performed. Phenotype (B/T lineage) was confirmed in all cases by flow cytometry. Cytogenetic analysis was made for all cases using the trypsin-Giemsa banding technique. Karyotypes were interpreted using the International System for Human Cytogenetic Nomenclature (ISCN) criteria. Results: A total of 166 patients were diagnosed as ALL during the study period, of which 151 samples successfully yielded metaphase chromosomes. The male to female ratio was 3.4:1. The majority (n=120, 72.3%) had a B-cell phenotype. A normal karyotype was present in 51% (n=77) of the cases whereas 49% (n=74) had an abnormal karyotype. Of the abnormal cases, 10% showed Philadelphia chromosome; t(9;22)(q34;q11.2). Other poor prognostic cytogenetic subgroups were t(4;11)(q21;q23), hypodiploidy (35-45 chromosomes) and complex karyotype. Hyperdiploidy (47-57 chromosomes) occurred in 6.6%; all of whom were younger than 30 years. Conclusions: This study showed a relatively low prevalence of Philadelphia chromosome in Pakistani adults with ALL with an increase in frequency with age (p=0.003). The cumulative prevalence of Philadelphianegative poor cytogenetic aberrations in different age groups was not significant (p=0.6).

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Asian Pac J Cancer Prev, 15 (15), 6211-6217

IntroductionAcute lymphoblastic leukemia (ALL), the most common malignancy in children (Linabery and Ross, 2008;Jiang et al, 2013), is a heterogeneous disease, with respect to its underlying cellular and molecular biology (Papaemmanuil et al, 2009), acquired genetic abnormalities, and social clinical responses to combination chemotherapy (Pui et al, 2004). The mechanisms involved in the etiology of childhood ALL remain obscure.

…”

mentioning

confidence: 99%

Associations between AT-rich Interactive Domain 5B gene Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia: a Meta-analysis

Zeng

Wang²,

Cui³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 15 (15), 6211-6217 IntroductionAcute lymphoblastic leukemia (ALL), the most common malignancy in children (Linabery and Ross, 2008;Jiang et al., 2013), is a heterogeneous disease, with respect to its underlying cellular and molecular biology (Papaemmanuil et al., 2009), acquired genetic abnormalities, and social clinical responses to combination chemotherapy (Pui et al., 2004). The mechanisms involved in the etiology of childhood ALL remain obscure. It is hypothesized that both environmental and genetic factors contribute to the initiation of leukemogenesis (Greaves, 2006). Previous genome-wide association studies (GWAS) have implicated the associations of several single nucleotide polymorphisms (SNPs) in the AT-rich interactive domain 5B (ARID5B) gene with childhood ALL (Papaemmanuil et al., 2009;Trevino et al., 2009). Importantly, the ARID5B gene showed specificity for B lineage ALL and B-hyperdiploid subtype (Papaemmanuil et al., 2009;Trevino et al., 2009) ARID5B, the gene encoding the ARID5B protein, which located on chromosome 10q21.2, is one of the common susceptibility loci associated with childhood ALL risk (Papaemmanuil et al., 2009 Abstract Previous genome-wide association studies (GWAS) have implicated several single nucleotide polymorphisms (SNPs) in the AT-rich interactive domain 5B (ARID5B) gene with childhood acute lymphoblastic leukemia (ALL).However, replicated studies reported some inconsistent results in different populations. Using meta-analysis, we here aimed to clarify the nature of the genetic risks contributed by the two polymorphisms (rs10994982, rs7089424) for developing childhood ALL. Through searches of PubMed, EMBASE, and manually searching relevant references, a total of 14 articles with 16 independent studies were included. Odds ratios (ORs) with 95% confidence intervals (95%CI) were calculated to assess the associations. Both SNPs rs10994982 and rs7089424 showed significant associations with childhood ALL risk in all genetic models after Bonferroni correction. Furthermore, subtype analyses of B-lineage ALL provided strong evidence that SNP rs10994982 is highly associated with the risk of developing B-hyperdiploid ALL. These results indicate that SNPs rs10994982 and rs7089424 are indeed significantly associated with increased risk of childhood ALL.

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The MTHFR C677T Polymorphism and Risk of Acute Lymphoblastic Leukemia: an Updated Meta-analysis Based on 37 Case-control Studies

Cited by 23 publications

References 46 publications

Elevated Serum Ferritin Levels in Patients with Hematologic Malignancies

Elevated Serum Ferritin Levels in Patients with Hematologic Malignancies

Frequency of Chromosomal Abnormalities in Pakistani Adults with Acute Lymphoblastic Leukemia

Associations between AT-rich Interactive Domain 5B gene Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia: a Meta-analysis

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