Associations between AT-rich Interactive Domain 5B gene Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia: a Meta-analysis

Zeng, Hui; Wang, Xuebin; Cui, Naiqiang; Nam, Seungyoon; Zeng, Tuo; Long, Xinghua

doi:10.7314/apjcp.2014.15.15.6211

Cited by 11 publications

(5 citation statements)

References 48 publications

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“…Forty-two genes were considered biological ALL risk genes. In line with several metanalyses, we found that ARID5B was the most plausible gene [14][15][16].…”

Section: Discussionsupporting

confidence: 85%

Identification of Potential Treatments for Acute Lymphoblastic Leukemia through Integrated Genomic Network Analysis

et al. 2022

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The advancement of high-throughput sequencing and genomic analysis revealed that acute lymphoblastic leukemia (ALL) is a genetically heterogeneous disease. The abundance of such genetic data in ALL can also be utilized to identify potential targets for drug discovery and even drug repurposing. We aimed to determine potential genes for drug development and further guide the identification of candidate drugs repurposed for treating ALL through integrated genomic network analysis. Genetic variants associated with ALL were retrieved from the GWAS Catalog. We further applied a genomic-driven drug repurposing approach based on the six functional annotations to prioritize crucial biological ALL-related genes based on the scoring system. Lastly, we identified the potential drugs in which the mechanisms overlapped with the therapeutic targets and prioritized the candidate drugs using Connectivity Map (CMap) analysis. Forty-two genes were considered biological ALL-risk genes with ARID5B topping the list. Based on potentially druggable genes that we identified, palbociclib, sirolimus, and tacrolimus were under clinical trial for ALL. Additionally, chlorprothixene, sirolimus, dihydroergocristine, papaverine, and tamoxifen are the top five drug repositioning candidates for ALL according to the CMap score with dasatinib as a comparator. In conclusion, this study determines the practicability and the potential of integrated genomic network analysis in driving drug discovery in ALL.

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“…Forty-two genes were considered biological ALL risk genes. In line with several metanalyses, we found that ARID5B was the most plausible gene [14][15][16].…”

Section: Discussionsupporting

confidence: 85%

Identification of Potential Treatments for Acute Lymphoblastic Leukemia through Integrated Genomic Network Analysis

et al. 2022

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“…In a previous study, they reported the association between rs2393782 and rs4948488 with the risk to -León et al, 2019). Previous research studies showed that ARID5B rs7089424 and rs10994982 were associated with the risk of B-ALL development (Zeng et al, 2014). This might be explained by the role of recombination activation gene (RAG1) in early B-cell differentiation (Tao et al, 2019).…”

Section: Discussionmentioning

confidence: 98%

Association of two ARID5B gene variant single nucleotide polymorphisms with acute lymphoblastic leukemia in the Egyptian population

Gamaleldin

Imbaby

2023

Asian Pac J Cancer Prev

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Background: ARID5B SNPs have been linked to ALL in many research studies in which it was identified as a risk factor. From this context, we had great interest to investigate the relationship between ARID5B rs4948488 and ARID5B rs2893881 genotypes and ALL susceptibility and relapse in this study. Materials and Methods: Peripheral blood mononuclear cells were analyzed for ARID5B rs4948488 and rs2893881 gene polymorphisms by real-time quantitative polymerase chain reaction in 80 ALL patients and 80 controls. Results: Our results showed that the C/C genotype of ARID5B rs4948488 and A/G genotype and G-allele of rs2893881 were linked to higher ALL incidence. Regarding the relapse of ALL, rs4948488 C/C genotype and C-alleles were significantly associated with relapse of ALL. Meanwhile, rs4948488 C/C genotype and rs2893881 A/A genotype and A-allele are associated with T-ALL, while rs2893881 A/G genotype and G-allele are associated with B-ALL. Conclusion: The results of our study suggested that ARID5B rs4948488 and rs2893881 SNPs might be used risk factors for genetic susceptibility for B-ALL and T-ALL, and that ARID5B s4948488 is related to relapse in ALL patients.

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“…The specific function of this highly conserved element has not been fully elucidated, but it is located between ARID5B and RTKN2 ( Jiang et al, 2014 ), both of which have been linked to roles in regulation of immune responses. ARID5B encodes a DNA-binding protein with roles in NK cell function ( Cichocki et al, 2018 ), cancers of both B and T lymphocytes ( Healy et al, 2010 ; Zeng et al, 2014 ; Leong et al, 2017 ), and autoimmune disease ( Wang et al, 2012 ; Yang et al, 2013 ). The RTKN2 gene is expressed in lymphocytes ( Collier et al, 2004 ), induces an NF-kB-dependent hold on apoptosis ( Collier et al, 2009 ) that can change counts and function of available immune cells, and has been implicated in autoimmune disease ( Myouzen et al, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Genome-wide association with footrot in hair and wool sheep

Cinar,

Oliveira,

Hadfield

et al. 2024

Front. Genet.

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Ovine footrot is an infectious disease with important contributions from Dichelobacter nodosus and Fusobacterium necrophorum. Footrot is characterized by separation of the hoof from underlying tissue, and this causes severe lameness that negatively impacts animal wellbeing, growth, and profitability. Large economic losses result from lost production as well as treatment costs, and improved genetic tools to address footrot are a valuable long-term goal. Prior genetic studies had examined European wool sheep, but hair sheep breeds such as Katahdin and Blackbelly have been reported to have increased resistance to footrot, as well as to intestinal parasites. Thus, footrot condition scores were collected from 251 U.S. sheep including Katahdin, Blackbelly, and European-influenced crossbred sheep with direct and imputed genotypes at OvineHD array (>500,000 single nucleotide polymorphism) density. Genome-wide association was performed with a mixed model accounting for farm and principal components derived from animal genotypes, as well as a random term for the genomic relationship matrix. We identified three genome-wide significant associations, including SNPs in or near GBP6 and TCHH. We also identified 33 additional associated SNPs with genome-wide suggestive evidence, including a cluster of 6 SNPs in a peak near the genome-wide significance threshold located near the glutamine transporter gene SLC38A1. These findings suggest genetic susceptibility to footrot may be influenced by genes involved in divergent biological processes such as immune responses, nutrient availability, and hoof growth and integrity. This is the first genome-wide study to investigate susceptibility to footrot by including hair sheep and also the first study of any kind to identify multiple genome-wide significant associations with ovine footrot. These results provide a foundation for developing genetic tests for marker-assisted selection to improve resistance to ovine footrot once additional steps like fine mapping and validation are complete.

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Associations between AT-rich Interactive Domain 5B gene Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia: a Meta-analysis

Cited by 11 publications

References 48 publications

Identification of Potential Treatments for Acute Lymphoblastic Leukemia through Integrated Genomic Network Analysis

Identification of Potential Treatments for Acute Lymphoblastic Leukemia through Integrated Genomic Network Analysis

Association of two ARID5B gene variant single nucleotide polymorphisms with acute lymphoblastic leukemia in the Egyptian population

Genome-wide association with footrot in hair and wool sheep

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