The Midwest Exercise Trial for the Prevention of Weight Regain: MET POWeR

Szabo, Amanda N.; Washburn, Richard A.; Sullivan, Debra K.; Honas, Jeffery J.; Mayo, Matthew S.; Goetz, Jeannine; Lee, Jae‐Hoon; Donnelly, Joseph E.

doi:10.1016/j.cct.2013.08.011

Cited by 6 publications

(8 citation statements)

References 48 publications

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“…A detailed description of the rationale and design for (MET‐POWeR) has been published (19). Adults with overweight or obesity ( n = 298) initiated a 3‐month behavioral WL intervention (−3 to 0 months).…”

Section: Methodsmentioning

confidence: 99%

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A Randomized Trial Evaluating Exercise for the Prevention of Weight Regain

Washburn

Szabo-Reed

Gorczyca

et al. 2020

Obesity

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Objective This study aimed to evaluate the effectiveness of three levels of exercise on weight regain subsequent to clinically meaningful weight loss (WL). Methods Adults with overweight or obesity (n = 298) initiated a 3‐month behavioral WL intervention, which included reduced energy intake, increased exercise, and weekly behavioral counseling. Participants achieving ≥5% WL (n = 235) began a 12‐month behavioral WL maintenance intervention and were randomized to 150 min/wk (n = 76), 225 min/wk (n = 80), or 300 min/wk (n = 79) of partially supervised moderate‐to‐vigorous–intensity exercise. Results Participants randomized to 150, 225, and 300 minutes of exercise completed 129 ± 30, 153 ± 49 and 179 ± 62 min/wk of exercise (supervised + unsupervised), respectively. Mean WL at 3 months (9.5 ± 3.1 kg) was similar across randomized groups (P = 0.68). Weight change across 12 months was 1.1 ± 6.5 kg, 3.2 ± 5.7 kg, and 2.8 ± 6.9 kg in the 150, 225, and 300 min/wk groups, respectively. Intent‐to‐treat analysis revealed no significant overall trend across the three treatment groups (P = 0.09), effects for group (P = 0.08), or sex (P = 0.21). Conclusions This study found no evidence for an association between the volume of moderate‐to‐vigorous–intensity exercise and weight regain across 12 months following clinically relevant WL. Further, results suggest that exercise volumes lower than those currently recommended for WL maintenance, when completed in conjunction with a behavioral weight‐maintenance intervention, may minimize weight regain over 12 months.

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Section: Methodsmentioning

confidence: 99%

“…The power and sample size were discussed in detail in our previously published rationale and design paper (19). Briefly, sample size estimates were based on an expected weight change (0‐12 months) of 8 kg, 5 kg, and 2 kg with a common SD of 6 kg and a type 1 error rate of 5%.…”

Section: Methodsmentioning

confidence: 99%

A Randomized Trial Evaluating Exercise for the Prevention of Weight Regain

Washburn

Szabo-Reed

Gorczyca

et al. 2020

Obesity

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“…Although cardiovascular risk associated with adiposity can be mitigated by weight loss, the impact is rarely sustainable. Short term weight loss can be achieved with caloric restriction and lifestyle modifications, but approximately half of patients who achieve weight loss will regain up to 75% of the lost weight following 12–30 months of treatment completion [Donnelly et al 2013]. It is unknown how weight regain impacts the androgenic profile, a critical marker of metabolic dysregulation.…”

Section: Introductionmentioning

confidence: 99%

The impact of supervised weight loss and intentional weight regain on sex hormone binding globulin and testosterone in premenopausal women

Aubuchon

Liu

Petroski

et al. 2016

Systems Biology in Reproductive Medicine

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What is the impact of intentional weight loss and regain on serum androgens in women? We conducted an ancillary analysis of prospectively collected samples from a randomized controlled trial. The trial involved supervised 10% weight loss (8.5 kg on average) with diet and exercise over 4–6 months followed by supervised intentional regain of 50% of the lost weight (4.6 kg on average) over 4–6 months. Participants were randomized prior to the partial weight regain component to either continuation or cessation of endurance exercise. Analytic sample included 30 obese premenopausal women (mean age of 40 ± 5.9 years, mean baseline body mass index (BMI) of 32.9 ± 4.2 kg/m2) with metabolic syndrome. We evaluated sex hormone binding globulin (SHBG), total testosterone (T), free androgen index (FAI), and high molecular weight adiponectin (HMWAdp). Insulin, homeostasis model assessment (HOMA), and quantitative insulin sensitivity check index (QUICKI), and visceral adipose tissue (VAT) measured in the original trial were reanalyzed for the current analytic sample. Insulin, HOMA, and QUICKI improved with weight loss and were maintained despite weight regain. Log-transformed SHBG significantly increased from baseline to weight loss, and then significantly decreased with weight regain. LogFAI and logVAT decreased similarly and increased with weight loss followed by weight regain. No changes were found in logT and LogHMWAdp. There was no significant difference in any tested parameters by exercise between the groups. SHBG showed prominent sensitivity to body mass fluctuations, as reduction with controlled intentional weight regain showed an inverse relationship to VAT and occurred despite stable HMWAdp and sustained improvements with insulin resistance. FAI showed opposite changes to SHBG, while T did not change significantly with weight. Continued exercise during weight regain did not appear to impact these findings.

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“…Yet another major component in prevention is body weigh optimization. However, numerous studies involving restricted energy intake and increased physical activity have demonstrated only a short-term effect (not beyond 6 months and mere 5% body weight reduction (18).…”

Section: Discussionmentioning

confidence: 99%

Physical Activity and Exercise as a Basic Preventive Measure (Primary Prevention, Prevention after Renal Transplantation)

Adámková¹,

Bělohoubek²,

Adámek³

et al. 2015

Cent Eur J Public Health

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Movement is an inseparable part of one's life, and has been a basic everyday activity through the history of mankind. However, a lack of physical activity and availability of food have resulted in a variety of serious health impairments. The 20th century has witnessed a steep rise of mortality from cardiovascular disease, increase in the prevalence of type-2 diabetes mellitus, malignant diseases, and dramatic increase in body weight initially in industrialized nations followed, in the last two decades of the last century, by the populations of third-world countries with all inherent consequences of this phenomenon. Preventive programmes involving physical activity have also been on the list of top priorities of various materials issued by the World Health Organization. Physical activity is one of the simplest non-pharmacological tools in the prevention of a plethora of diseases. The simplest physical activity, even for therapeutic purposes, is walking. We can walk any time, virtually anywhere, so walking is also the least expensive therapeutic option.

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The Midwest Exercise Trial for the Prevention of Weight Regain: MET POWeR

Cited by 6 publications

References 48 publications

A Randomized Trial Evaluating Exercise for the Prevention of Weight Regain

A Randomized Trial Evaluating Exercise for the Prevention of Weight Regain

The impact of supervised weight loss and intentional weight regain on sex hormone binding globulin and testosterone in premenopausal women

Physical Activity and Exercise as a Basic Preventive Measure (Primary Prevention, Prevention after Renal Transplantation)

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