“…During gastrointestinal passage, they undergo extensive metabo-lism similar to that shown for other compounds, such as epigallocatechin-3-O-gallate [5]. Free hydroxycinnamic acids and its esters with D-(-)-quinic acid, free aglyca of the ingested flavonoids, as well as glucuronides, sulfates, and other derivatives, such as methylated compounds, can be found in ileal fluid, plasma, and urine after the consumption of apple products [6]. For example, after the consumption of 1 L of cloudy apple juice, less than 1 to 80 µM of the ingested polyphenols were determined in the ileostomy effluents of volunteers, representing the amounts reaching the colon in healthy subjects [7,8].…”