The Met-allele of the BDNF Val66Met polymorphism enhances task switching in elderly

Gajewski, Patrick D.; Hengstler, Jan G.; Golka, Klaus; Falkenstein, Michael; Beste, Christian

doi:10.1016/j.neurobiolaging.2011.06.010

Cited by 96 publications

(118 citation statements)

References 59 publications

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“…Checking of analysis sorted participants to three genetic categories: val/val (46 people), val/met (40 people), and met/met (14 people). The genotype's distribution of Val66Met polymorphism observed in both val/val and val/ met genotype satisfied the Hardy-Weinberg Equilibrium and were comparable with that previously observed in previous studies [17][18][19] . The experiment leader in this study was blinded for the genotype of the participants.…”

Section: Bdnf Genotypingsupporting

confidence: 89%

Do Environmental Factors (Practice and Feedback) Moderate the Effect of the Val66met BDNF Polymorphism on Motor Learning?

Nooshabadi¹,

Kakhki²,

Sohrabi³

et al. 2016

Biosci., Biotech. Res. Asia

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Motor learning might be affected by environmental factors as well as some genetic factors. The aim of the present study is to examine the effect of val66met BDNF polymorphism on motor learning and to examine the possibility of moderating this effect using environmental factors. One hundred students from University of Kashan, Iran participated in the study. After extraction of Genomic DNA, implementation of polymerase chain reaction (PCR), analyzing PCR by 1.5 percent Electrophoresis Gel, and in the end sequencing by ABI PRISM 7000 Sequencing Analyzer, 46 participants were identified without val66met polymorphism while 54 participants were affected by the polymorphism (met-carrier). Twenty-four participants without val66met polymorphism and Twenty-four participants of met-carriers were randomly selected and divided into four groups of twelve. Participants of each group practiced backhand baseball pitch for six sessions and after 48 hours did the first retention test. Subsequently, participants in all four groups continued practicing in three additional sessions with specific design for each group and afterwards did the second retention test. Results demonstrate the fact that participants without the polymorphism exceeded met-carriers in learning of the task. Whereas the weakness of met-carriers did not disappear by additional practice, the practice was useful when associated with self-controlled feedback. The research shows val66met polymorphism may exert an influence over the learning of motor skills. However, the effect may be moderated by changing the condition of practice for people affected by the polymorphism in a way that engages them to cognitive processes.

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Section: Bdnf Genotypingsupporting

confidence: 89%

Do Environmental Factors (Practice and Feedback) Moderate the Effect of the Val66met BDNF Polymorphism on Motor Learning?

Nooshabadi¹,

Kakhki²,

Sohrabi³

et al. 2016

Biosci., Biotech. Res. Asia

View full text Add to dashboard Cite

show abstract

“…One previous report using data from older adults suggested that the BDNF Met allele is associated with higher memory performance, 35 whereas other studies found no effect of BDNF Val66Met variant on memory in older 14,16,36 or young adults. 15,17 Differences in socioeconomic status as well as in age range between the samples analyzed in these studies might explain these contradictory findings.…”

Section: Discussionmentioning

confidence: 94%

“…Unfortunately, studies with healthy elderly subjects represent a challenge in this field. Finally, it is already known that the BDNF Val66Met polymorphism has effects on other cognitive domains besides memory, including distinct components of executive functions, 35,38 reasoning, 16 attention, 39 and visualauditory working memory. 40 Therefore, we were not able to restrict the effects of this SNP to memory.…”

Section: Discussionmentioning

confidence: 99%

The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults

Azeredo

Nardi

Levandowski

et al. 2017

Rev. Bras. Psiquiatr.

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Objective: Memory impairment is an important contributor to the reduction in quality of life experienced by older adults, and genetic risk factors seem to contribute to variance in age-related cognitive decline. Brain-derived neurotrophic factor (BDNF) is an important nerve growth factor linked with development and neural plasticity. The Val66Met polymorphism in the BDNF gene has been associated with impaired episodic memory in adults, but whether this functional variant plays a role in cognitive aging remains unclear. The purpose of this study was to investigate the effects of the BDNF Val66Met polymorphism on memory performance in a sample of elderly adults. Methods: Eighty-seven subjects aged 4 55 years were recruited using a community-based convenience sampling strategy in Porto Alegre, Brazil. The logical memory subset of the Wechsler Memory Scale-Revised was used to assess immediate verbal recall (IVR), delayed verbal recall (DVR), and memory retention rate. Results: BDNF Met allele carriers had lower DVR scores (p = 0.004) and a decline in memory retention (p = 0.017) when compared to Val/Val homozygotes. However, we found no significant differences in IVR between the two groups (p = 0.088). Conclusion: These results support the hypothesis of the BDNF Val66Met polymorphism as a risk factor associated with cognitive impairment, corroborating previous findings in young and older adults.

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“…A recent study from our group in patients with schizophrenia (SZ) showed that duration of illness, but not age itself, is related to many markers of aging; these results are consistent with the hypothesis of accelerated aging induced by a pathological state. 2 Still, SZ is associated with a higher burden of disease. In our recent study, the similar LTL among early-stage and late-stage BD patients could indeed have many other explanations.…”

mentioning

confidence: 99%

Analyzing leukocyte telomere length in bipolar disorder: Authors’ reply

Barbé-Tuana

Parisi

Panizzutti

et al. 2017

Rev. Bras. Psiquiatr.

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Our original study adds important information to the evidence base for bipolar disorder (BD) pathology. We show, for the first time, that shorter leukocyte telomere length (LTL) is already present in individuals with the early stages of BD and is comparable to LTL from individuals in the late stages of the disease. This result is at least surprising. We might speculate that, in BD, LTL would be proportional to disease duration. A recent study from our group in patients with schizophrenia (SZ) showed that duration of illness, but not age itself, is related to many markers of aging; these results are consistent with the hypothesis of accelerated aging induced by a pathological state.2 Still, SZ is associated with a higher burden of disease. In our recent study, the similar LTL among early-stage and late-stage BD patients could indeed have many other explanations.First, although hypertension, dyslipidemia, and diabetes mellitus are risk factors for telomere erosion and senescence, and were present in our cohort of BD patients, we chose not to report these data, because we have no information regarding comorbidity duration and its differential impact. Telomeres are naturally shortened during cell division and this process can be accelerated under oxidative, inflammatory or glucocorticoid stress, all of which are present in patients with BD. Importantly, augmented peripheral cell apoptosis, which may be a consequence of augmented turn-over secondary to chronic stress, has been reported in BD. Thus, during chronic stress, cells with shorter telomeres might have already been eliminated, selecting for medium to large telomeres. Second, quantification of telomere length by quantitative PCR (qPCR) provides a measure of the mean LTL present in a given cell population. A major limitation of this technique is its sensitivity, as qPCR does not detect short telomeres. Because short but not average LTL determines pathological phenotypes and drives cell fate, our results must be interpreted with caution.In addition, LTL is a mosaic trait, and reflects the replicative history of the analyzed tissue. Granulocytes have longer telomeres than any other leukocyte subset and are present in higher numbers in BD patients. LTL from patients with late-stage BD could be enriched in the granulocyte population, leading to overestimation and misinterpretation of the real impact of LTL. Finally, we could also argue that similar LTL could be a consequence of pharmacotherapy. Lithium therapy is associated with neuroprotective properties.3 This effect could explain why euthymic patients in late-stage BD under longer lithium therapy might have similar LTL to early-stage BD patients.Two recently published reports from our group address telomere shortening and familial traits in BD 4 and SZ. 5Our findings show a significant negative trend for shorter LTL among patients with BD when compared to their healthy siblings, and similar and shorter LTL among patients with SZ and their unaffected siblings. More importantly, in both studies, LTL was shorter in...

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The Met-allele of the BDNF Val66Met polymorphism enhances task switching in elderly

Cited by 96 publications

References 59 publications

Do Environmental Factors (Practice and Feedback) Moderate the Effect of the Val66met BDNF Polymorphism on Motor Learning?

Do Environmental Factors (Practice and Feedback) Moderate the Effect of the Val66met BDNF Polymorphism on Motor Learning?

The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults

Analyzing leukocyte telomere length in bipolar disorder: Authors’ reply

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