The mechanism of nanoparticle-mediated enhanced energy transfer during high-intensity focused ultrasound sonication

Bera, Chandan; Devarakonda, Surendra B.; Kumar, V. Ramesh; Ganguli, Ashok K.; Banerjee, Rupak K.

doi:10.1039/c7cp03542j

Cited by 25 publications

(20 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These structures are indeed able to enhance HIFU-associated mechanical effects, providing cavitation nuclei [48]. Furthermore, they increase the acoustic attenuation with a consequent temperature rise [51], reducing the ultrasound intensity and the exposure time required to obtain bioeffects [47].…”

Section: High Intensity Focused Ultrasoundmentioning

confidence: 99%

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Canavese

Ancona

Racca

et al. 2018

Chemical Engineering Journal

327

247

View full text Add to dashboard Cite

• Ultrasound-based therapies are opening new horizons in the oncological field.• Innovative and promising solutions derive from different nanoparticles-assisted ultrasound treatments.• Sonodynamic therapy (SDT) emerged recently as a novel approach for cancer treatment.• Different and complex cell death mechanisms are involved in nanoparticles-assisted SDT.• Nanoparticles-assisted ultrasound is still at its infancy in clinics. A R T I C L E I N F O Keywords:Inertial cavitation Reactive oxygen species Sonoluminescence Sonodynamic Tumor Therapy Cytotoxicity A B S T R A C TAt present, ultrasound radiation is broadly employed in medicine for both diagnostic and therapeutic purposes at various frequencies and intensities. In this review article, we focus on therapeutically-active nanoparticles (NPs) when stimulated by ultrasound. We first introduce the different ultrasound-based therapies with special attention to the techniques involved in the oncological field, then we summarize the different NPs used, ranging from soft materials, like liposomes or micro/nano-bubbles, to metal and metal oxide NPs. We therefore focus on the sonodynamic therapy and on the possible working mechanisms under debate of NPs-assisted sonodynamic treatments. We support the idea that various, complex and synergistics physical-chemical processes take place during acoustic cavitation and NP activation. Different mechanisms are therefore responsible for the final cancer cell death and strongly depends not only on the type and structure of NPs or nanocarriers, but also on the way they interact with the ultrasonic pressure waves. We conclude with a brief overview of the clinical applications of the various ultrasound therapies and the related use of NPs-assisted ultrasound in clinics, showing that this very innovative and promising approach is however still at its infancy in the clinical cancer treatment.

show abstract

Section: High Intensity Focused Ultrasoundmentioning

confidence: 99%

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Canavese

Ancona

Racca

et al. 2018

Chemical Engineering Journal

327

247

View full text Add to dashboard Cite

show abstract

“…The ultrasonic absorption model explaining the increased heating in materials doped with magnetic nanoparticles was proposed . The authors introduced a new heat source, which was interpreted as a “phonon layer” on the border between the magnetic nanoparticles and the surrounding matrix.…”

Section: Introductionmentioning

confidence: 72%

“…The ultrasonic absorption model explaining the increased heating in materials doped with magnetic nanoparticles was proposed. 11 The authors introduced a new heat source, which was interpreted as a "phonon layer" on the border between the magnetic nanoparticles and the surrounding matrix. Ultrasonic impact with this phonon layer leads to increased heat production higher than in the case of the boundary of nonmagnetic nanoparticles and the same matrix.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound assessment of the conversion of sound energy into heat in tissue phantoms enriched with magnetic micro‐ and nanoparticles

et al. 2019

View full text Add to dashboard Cite

Purpose Nowadays, the improvement of ultrasonic hyperthermia therapy is often achieved by adding hard particles to the sonicated medium in order to increase the heating efficiency. The explanation of the phenomenon of ultrasonic heating still requires testing on tissue mimicking materials (TMMs), enriched with particles of different sizes and physical properties. Our goal was to determine, by comparing their quantitative acoustic properties, which TMMs, with magnetic micro‐ or nanoparticles, convert more ultrasonic energy into heat or which of the particles embedded in the agar gel act as more effective thermal sonosensitizers. Methods We manufactured a pure agar gel and an agar gel with the addition of magnetic micro‐ or nanoparticles in two proportions of 8 and 16 mg/ml. Ultrasound quantitative techniques, the broadband reflection substitution technique and backscattered spectrum analysis were used to characterize the samples by speed of sound (SOS), frequency‐dependent attenuation, and backscattering coefficients. The integrated backscattering coefficients were also calculated. The quantitative parameters, scattering, and attenuation coefficients of ultrasound in phantoms with micro‐ and nanoparticles were estimated. Based on the attenuation and scattering of ultrasound in the samples, the ultrasonic energy absorption, which determines the heating efficiency, was evaluated. Additionally, the temperature increase during sonication of the phantoms by an ultrasonic beam was directly measured using thermocouples. Results The density of the materials with nanoparticles was higher than for the materials with microparticles with the same fractions of particles. The SOS for all materials ranged from 1489 to 1499 m/s. The attenuation in the whole frequency range (3–8 MHz) was higher for the materials with nanoparticles than for the materials with microparticles. For the materials with the lower content (8 mg/ml) of particles, the attenuation coefficient was 0.2 dB/(MHz cm). For the 16 mg/ml concentration of nanoparticles and microparticles, the attenuation coefficients were 0.66 and 0.45 dB/(MHz cm), respectively. The value of backscattering coefficient in the whole frequency range was greater for the materials with microparticles than for the materials with nanoparticles. The values of the integrated backscattering coefficient were 0.05 and 0.08 1/m for the materials with nanoparticles and 0.46 and 0.82 1/m for the materials with microparticles and concentrations of 8 and 16 mg/ml, respectively. The rates of temperature increase in the first 3 s due to ultrasonic heating were higher for the materials with nanoparticles than for the materials with microparticles. Conclusions Based on acoustical measurements, we confirmed that all materials can be used as tissue phantoms in the study of ultrasonic hyperthermia, as their properties were in the range of soft tissue properties. We found that the nanoparticle‐doped materials had greater attenuation and smaller scattering of ultrasound than the materials with microparticles,...

show abstract

“…Proposed Analysis. In our previous work [26], we have reported that the HIFU absorption in media embedded with NPs depends on the thermal processes (viscous, phonon layers, and intrinsic absorption) at the interface of metal NPs and on the physical properties (such as density) of the media embedded with NPs [27][28][29][30]. The theoretical equation for temperature rise (DT) due to HIFU attenuation is given as…”

Section: Discussionmentioning

confidence: 99%

“…T 0 bv nf a nf P 0 q nf C nf Av m e anf vnf t dt (5) where C nf is the heat capacity, b is thermal expansion coefficient, q nf is the density of medium with NPs, v nf is the sound velocity in the medium, a nf is the total attenuation, A is the area of HIFU beam, T 0 is heat wave parameter, v m is the particle velocity, and P 0 is the HIFU acoustic power. Further details can be obtained from our previous study [26]. At a constant power P 0 , the temperature rise is a function of several parameters including T 0 , C nf , b, v nf , q nf , and a nf as reported in Eq.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Heat Transfer Enhancement Between Magnetic and Gold Nanoparticles During HIFU Sonication

Devarakonda

Myers

Banerjee

2018

Journal of Biomechanical Engineering

Self Cite

View full text Add to dashboard Cite

Long procedure times and collateral damage remain challenges in high-intensity focused ultrasound (HIFU) medical procedures. Magnetic nanoparticles (mNPs) and gold nanoparticles (gNPs) have the potential to reduce the acoustic intensity and/or exposure time required in these procedures. In this research, we investigated relative advantages of using gNPs and mNPs during HIFU thermal-ablation procedures. Tissue-mimicking phantoms containing embedded thermocouples (TCs) and physiologically acceptable concentrations (0.0625% and 0.125%) of gNPs were sonicated at acoustic powers of 5.2 W, 9.2 W, and 14.5 W, for 30 s. It was observed that when the concentration of gNPs was doubled from 0.0625% to 0.125%, the temperature rise increased by 80% for a power of 5.2 W. For a fixed concentration (0.0625%), the energy absorption was 1.7 times greater for mNPs than gNPs for a power of 5.2 W. Also, for the power of 14.5 W, the sonication time required to generate a lesion volume of 50 mm3 decreased by 1.4 times using mNPs, compared with gNPs, at a concentration of 0.0625%. We conclude that mNPs are more likely than gNPs to produce a thermal enhancement in HIFU ablation procedures.

show abstract

The mechanism of nanoparticle-mediated enhanced energy transfer during high-intensity focused ultrasound sonication

Cited by 25 publications

References 20 publications

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Ultrasound assessment of the conversion of sound energy into heat in tissue phantoms enriched with magnetic micro‐ and nanoparticles

Comparison of Heat Transfer Enhancement Between Magnetic and Gold Nanoparticles During HIFU Sonication

Contact Info

Product

Resources

About