The marine biodiscovery pipeline and ocean medicines of tomorrow

Jaspars, Marcel; Pascale, Donatella de; Andersen, Jeanette Hammer; Reyes, Fernando; Crawford, Alex D.; Ianora, Adrianna

doi:10.1017/s0025315415002106

Cited by 142 publications

(85 citation statements)

References 33 publications

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“…The marine environment is an exceptional source of both biological and chemical diversity, still largely unknown, although it has been exploited since ancient times. It has been estimated that 25% of the total number of species on Earth come from the marine environment . The uniqueness of this hostile environment in terms of light, salinity, pressure, space, gave birth to original organisms and bioactive substances, many of which exhibit characteristics not found in the terrestrial environment.…”

Section: Introductionmentioning

confidence: 99%

“…A recent review reported that researchers have isolated approximately 7000 marine natural compounds, 25% of which are derived from algae, 33% from sponges, 18% from coelenterates, and 24% from other invertebrate phyla . Recent reviews recorded the identification of more than 28 000 marine compounds, of which at least 3000 exhibit bioactive properties, and hundreds of new compounds being discovered each year . Few of them have been marketed or are under development, for various reasons including cost, time, and difficulties in harvesting the organism, low concentrations of natural compounds in producing organism, high toxicity of certain compounds, ecological issues, or insufficient investment by laboratories .…”

Section: Introductionmentioning

confidence: 99%

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Prediction of skin anti‐aging clinical benefits of an association of ingredients from marine and maritime origins: Ex vivo evaluation using a label‐free quantitative proteomic and customized data processing approach

Hameury

Borderie²,

Monneuse³

et al. 2018

J of Cosmetic Dermatology

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prediction of skin anti‐aging clinical benefits of an association of ingredients from marine and maritime origins: Ex vivo evaluation using a label‐free quantitative proteomic and customized data processing approach

Hameury

Borderie²,

Monneuse³

et al. 2018

J of Cosmetic Dermatology

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show abstract

“…Marine animals have been known to produce myriad of secondary metabolites (or natural products) with diverse chemical structures and an array biological properties [1,2]. Studies of the chemical properties of these secondary metabolites have led to discovery of lead compounds some of which have entered clinical trials, particularly as anticancer and antimicrobial agents [3].…”

Section: Introductionmentioning

confidence: 99%

Bioprospecting of the Balinese marine sponges and nudibranchs

Mudianta

2018

J. Phys.: Conf. Ser.

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Abstract. Secondary metabolites play an invaluable role as a starting point in drug discovery process. Among marine organisms, sponges and nudibranch mollusc (Mollusca: Gastropoda: Nudibranchia) have been the prolific sources of bioactive secondary metabolites with diverse chemical structures and promising bioactivities. This report presents the isolation and structure elucidation of bioactive natural products from the Balinese marine sponge Aplysinella strongylata and the nudibranchs Hypselodoris infucata and Glossodoris hikuerensis. The samples were collected from Tulamben beach Bali, an unexplored site but rich in marine biodiversity. The separation and purification of the metabolites were achieved by mean of NPflash column chromatography and HPLC. Structure elucidations of the isolated compounds were completed by analysis of spectroscopic dataset including 1 H and 2D NMR. A series of bromotyrosine-derived alkaloid possessing a spirooxepinisoxazoline moiety were identified from the extract of A. strongylata. One of the metabolites, 19-hydroxypsammaplysin E (1), showed the best antimalarial activity, with an IC50 value of 6.4 μM. The absolute configuration of psammaplysin series compounds has been assigned as (6R, 7R) using experimental and calculated electronic circular dichroism (ECD) data and NMR analysis of MPA esters prepared from the acetamide derivative of psammaplysin A. A furanosesquiterpen, (-)-furodysinin (2), was identified for the first time from the nudibranch H. infucata. The compound inhibited the growth of HeLa cell line at IC50 102.7 µg/mL. Two new scalarane sesterterpenes (3-4) were characterised from an organic extract of a single specimen of the nudibranch G. hikuerensis.

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“…Examples include the polysaccharides from cyanobacteria used in personal skin care products and extracts of Chlorella sp. which contain oligopeptides that can promote firmness of the skin [9]. In the pharmaceutical industries drug candidates with anti-inflammatory, anticancer, and anti-infective activities have been identified [10].…”

Section: Introductionmentioning

confidence: 99%

Extracellular Metabolites from Industrial Microalgae and Their Biotechnological Potential

2016

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Industrial microalgae, as a big family of promising producers of renewable biomass feedstock, have been commercially exploited for functional food, living feed and feed additives, high-value chemicals in nutraceuticals, cosmeceuticals, and chemical reagents. Recently, microalgae have also been considered as a group that might play an important role in biofuel development and environmental protection. Almost all current products of industrial microalgae are derived from their biomass; however, large amounts of spent cell-free media are available from mass cultivation that is mostly unexploited. In this contribution we discuss that these media, which may contain a remarkable diversity of bioactive substances are worthy to be recovered for further use. Obviously, the extracellular metabolites from industrial microalgae have long been neglected in the development of production methods for valuable metabolites. With the advances in the last ten years, more and more structures and properties from extracellular metabolites have been identified, and the potential utilization over wide fields is attracting attention. Some of these extracellular metabolites can be potentially used as drugs, antioxidants, growth regulators or metal chelators. The purpose of this review is to provide an overview of the known extracellular metabolites from industrial microalgae which might be of commercial interest. The attention mainly focuses on the reports of extracellular bioactive metabolites and their potential application in biotechnology.

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The marine biodiscovery pipeline and ocean medicines of tomorrow

Cited by 142 publications

References 33 publications

Prediction of skin anti‐aging clinical benefits of an association of ingredients from marine and maritime origins: Ex vivo evaluation using a label‐free quantitative proteomic and customized data processing approach

Prediction of skin anti‐aging clinical benefits of an association of ingredients from marine and maritime origins: Ex vivo evaluation using a label‐free quantitative proteomic and customized data processing approach

Bioprospecting of the Balinese marine sponges and nudibranchs

Extracellular Metabolites from Industrial Microalgae and Their Biotechnological Potential

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