Prediction of skin anti‐aging clinical benefits of an association of ingredients from marine and maritime origins: Ex vivo evaluation using a label‐free quantitative proteomic and customized data processing approach

Hameury, Sebastien; Borderie, Laurent; Monneuse, Jean‐Marc; Skorski, G.; Pradines, Dominique

doi:10.1111/jocd.12528

Cited by 10 publications

(10 citation statements)

References 62 publications

(101 reference statements)

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“…With this as motivation, we performed a time-course experiment to verify the effects QB on the epidermis in vitro 27 . We opted for the Reconstructed Human Epidermis (RHE) cell culture as this system mimics the in vivo 3D structure of epidermal tissue as well as the conditions and processes that occur in exposure to exogenous factors 23 .…”

Section: Resultsmentioning

confidence: 99%

“…Proteomics has served at the forefront as a tool for the development and evaluation of innovative cosmetic products 23 , 24 . Here, we investigated the proteomic alterations in human epidermis tridimensional (3D) cell culture (RHE), co-cultivated with dermal fibroblasts, after 0 h, 3 h, 6 h, 12 h, 24 h, and 48 h of exposure to quinoa bioester (QB); comparisons were performed with unexposed counterparts at the same time points.…”

Section: Introductionmentioning

confidence: 99%

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Proteomics reveals that quinoa bioester promotes replenishing effects in epidermal tissue

Camillo-Andrade

Santos

Fischer

et al. 2020

Sci Rep

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The continuous search for natural products that attenuate age-related losses has increasingly gained notice; among them, those applicable for skin care have drawn significant attention. The bioester generated from the Chenopodium quinoa’s oil is a natural-origin ingredient described to produce replenishing skin effects. With this as motivation, we used shotgun proteomics to study the effects of quinoa bioester on human reconstructed epidermis tridimensional cell cultures after 0, 3, 6, 12, 24, and 48 h of exposure. Our experimental setup employed reversed-phase nano-chromatography coupled online with an Orbitrap-XL and PatternLab for proteomics as the data analysis tool. Extracted ion chromatograms were obtained as surrogates for relative peptide quantitation. Our findings spotlight proteins with increased abundance, as compared to the untreated cell culture counterparts at the same timepoints, that were related to preventing premature aging, homeostasis, tissue regeneration, protection against ultraviolet radiation and oxidative damage.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Proteomics reveals that quinoa bioester promotes replenishing effects in epidermal tissue

Camillo-Andrade

Santos

Fischer

et al. 2020

Sci Rep

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“…The efficiency of mixtures of components has been described. Hameury et al [323] confirmed that an association of ingredients from marine origin revealed activity on the epidermis and the dermis, by regulation of proteins involved in gene expression, cell survival and metabolism, inflammatory processes, dermal extracellular matrix synthesis, melanogenesis and keratinocyte proliferation, migration, and differentiation, thus helping to prevent the visible signs of skin aging.…”

Section: Uv Protection Antioxidant and Antiagingmentioning

confidence: 96%

Applying Seaweed Compounds in Cosmetics, Cosmeceuticals and Nutricosmetics

et al. 2021

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The interest in seaweeds for cosmetic, cosmeceutics, and nutricosmetics is increasing based on the demand for natural ingredients. Seaweeds offer advantages in relation to their renewable character, wide distribution, and the richness and versatility of their valuable bioactive compounds, which can be used as ingredients, as additives, and as active agents in the formulation of skin care products. Bioactive compounds, such as polyphenols, polysaccharides, proteins, peptides, amino acids, lipids, vitamins, and minerals, are responsible for the biological properties associated with seaweeds. Seaweed fractions can also offer technical features, such as thickening, gelling, emulsifying, texturizing, or moistening to develop cohesive matrices. Furthermore, the possibility of valorizing industrial waste streams and algal blooms makes them an attractive, low cost, raw and renewable material. This review presents an updated summary of the activities of different seaweed compounds and fractions based on scientific and patent literature.

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“…Due to its fast growth rate and high polysaccharide content, including mannitol and alginate, giant kelp is a great candidate as feedstocks for biofuels (Camus et al, 2016). Giant kelp can also be used as an animal feed supplement and has extractable bio-active compounds that can be used in a wide variety of applications, such as fertilizer supplement to cosmetics to antioxidant activity (Arioli et al, 2015;Makkar et al, 2016;Tanna and Mishra, 2018;Hameury et al, 2019). Seaweed domestication has been hampered by limited starting gene pools and clonal propagation techniques.…”

Section: Introductionmentioning

confidence: 99%

Sporophyte Stage Genes Exhibit Stronger Selection Than Gametophyte Stage Genes in Haplodiplontic Giant Kelp

et al. 2022

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Macrocystis pyrifera (giant kelp), a haplodiplontic brown macroalga that alternates between a macroscopic diploid (sporophyte) and a microscopic haploid (gametophyte) phase, provides an ideal system to investigate how ploidy background affects the evolutionary history of a gene. In M. pyrifera, the same genome is subjected to different selective pressures and environments as it alternates between haploid and diploid life stages. We assembled M. pyrifera gene models using available expression data and validated 8,292 genes models using the model alga Ectocarpus siliculosus. Differential expression analysis identified gene models expressed in either or both the haploid and diploid life stages while functional annotation identified processes enriched in each stage. Genes expressed preferentially or exclusively in the gametophyte stage were found to have higher nucleotide diversity (π = 2.3 × 10–3 and 2.8 × 10–3, respectively) than those for sporophytes (π = 1.1 × 10–3 and 1 × 10–3, respectively). While gametophyte-biased genes show faster sequence evolution, the sequence evolution exhibits less signatures of adaptations when compared to sporophyte-biased genes. Our findings contrast the standing masking hypothesis, which predicts higher standing genetic variation at the sporophyte stage, and support the strength of expression theory, which posits that genes expressed more strongly are expected to evolve slower. We argue that the sporophyte stage undergoes more stringent selection compared with the gametophyte stage, which carries a heavy genetic load associated with broadcast spawning. Furthermore, using whole-genome sequencing, we confirm the strong population structure in wild M. pyrifera populations previously established using microsatellite markers, and estimate population genetic parameters, such as pairwise genetic diversity and Tajima’s D, important for conservation and domestication of M. pyrifera.

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Prediction of skin anti‐aging clinical benefits of an association of ingredients from marine and maritime origins: Ex vivo evaluation using a label‐free quantitative proteomic and customized data processing approach

Abstract: These results suggest that the tested ingredients could help to preserve a healthy epidermis and dermis, and possibly to prevent the visible signs of skin aging.

Cited by 10 publications

References 62 publications

Proteomics reveals that quinoa bioester promotes replenishing effects in epidermal tissue

Proteomics reveals that quinoa bioester promotes replenishing effects in epidermal tissue

Applying Seaweed Compounds in Cosmetics, Cosmeceuticals and Nutricosmetics

Sporophyte Stage Genes Exhibit Stronger Selection Than Gametophyte Stage Genes in Haplodiplontic Giant Kelp

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