The Maintenance of Single-Locus Polymorphism. II. The Evolution of Fitnesses and Allele Frequencies

Marks, R. William; Spencer, Hamish G.

doi:10.1086/285291

Cited by 30 publications

(60 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Somewhat counter to expectation, equilibrium distributions of alleles remain far less centered than expected by chance. Our results here mirror the findings of the constant-viability construction approach studies done in the 1990s (Spencer and Marks 1988, 1992, 1993Marks and Spencer 1991). They found that constantviability construction approaches produce allele-frequency distributions that are less central than expected by chance (Marks and Spencer 1991;Spencer and Marks 1992, Figure 1).…”

Section: Discussionsupporting

confidence: 89%

“…Our results here mirror the findings of the constant-viability construction approach studies done in the 1990s (Spencer and Marks 1988, 1992, 1993Marks and Spencer 1991). They found that constantviability construction approaches produce allele-frequency distributions that are less central than expected by chance (Marks and Spencer 1991;Spencer and Marks 1992, Figure 1). Constant-viability parameter-space approaches predict that highly polymorphic allelefrequency distributions will be more central than expected by chance (Lewontin et al 1978, Figure 3) and so are also much more central than constructed polymorphisms.…”

Section: Discussionsupporting

confidence: 89%

“…It is encouraging that this construction approach to the PIM, which borrows from both ecological (Ginzburg et al 1988;Akcakaya and Ginzburg 1991) and evolutionary construction Marks 1988, 1992;Marks and Spencer 1991) traditions, is able to explain larger amounts of variation than its progenitors.…”

Section: Discussionmentioning

confidence: 95%

“…Early construction models found that constant selection can generate large numbers of alleles when combined with a mutational process (Spencer and Marks 1988). This type of approach has been used to investigate the dynamics of the invasion/extinction process, the effect of different mutational fitness distributions (Marks and Spencer 1991;Spencer and Marks 1992), and selection in spatially structured populations (Star et al 2007).…”

mentioning

confidence: 99%

See 3 more Smart Citations

The Generation and Maintenance of Genetic Variation by Frequency-Dependent Selection: Constructing Polymorphisms Under the Pairwise Interaction Model

Trotter

Spencer

2008

Genetics

View full text Add to dashboard Cite

Frequency-dependent selection remains the most commonly invoked heuristic explanation for the maintenance of genetic variation. For polymorphism to exist, new alleles must be both generated and maintained in the population. Here we use a construction approach to model frequency-dependent selection with mutation under the pairwise interaction model. The pairwise interaction model is a general model of frequency-dependent selection at the genotypic level. We find that frequency-dependent selection is able to generate a large number of alleles at a single locus. The construction process generates multiallelic polymorphisms with a wide range of allele-frequency distributions and genotypic fitness relationships. Levels of polymorphism and mean fitness are uncoupled, so constructed polymorphisms remain permanently invasible to new mutants; thus the model never settles down to an equilibrium state. Analysis of constructed fitness sets reveals signatures of heterozygote advantage and positive frequency dependence.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 95%

mentioning

confidence: 99%

See 2 more Smart Citations

The Generation and Maintenance of Genetic Variation by Frequency-Dependent Selection: Constructing Polymorphisms Under the Pairwise Interaction Model

Trotter

Spencer

2008

Genetics

View full text Add to dashboard Cite

show abstract

“…Thus, we can define three types of fitness sets as in (Star et al 2007a): all initial allele-frequency vectors iterated to a fully polymorphic equilibrium for type I fitness sets; some, but not all, initial allele-frequency vectors did so for type II fitness sets; and no vectors did for type III fitness sets. Type III fitness sets may occur because the iterations were stopped after an arbitrary time and equilibrium conditions may not have been reached (Marks and Spencer 1991). Therefore, deleterious alleles may be present in the recorded fitness sets after 10,000 generations.…”

Section: Nmentioning

confidence: 99%

Effects of Genetic Drift and Gene Flow on the Selective Maintenance of Genetic Variation

Star

Spencer

2013

Genetics

View full text Add to dashboard Cite

Explanations for the genetic variation ubiquitous in natural populations are often classified by the population-genetic processes they emphasize: natural selection or mutation and genetic drift. Here we investigate models that incorporate all three processes in a spatially structured population, using what we call a construction approach, simulating finite populations under selection that are bombarded with a steady stream of novel mutations. As expected, the amount of genetic variation compared to previous models that ignored the stochastic effects of drift was reduced, especially for smaller populations and when spatial structure was most profound. By contrast, however, for higher levels of gene flow and larger population sizes, the amount of genetic variation found after many generations was greater than that in simulations without drift. This increased amount of genetic variation is due to the introduction of slightly deleterious alleles by genetic drift and this process is more efficient when migration load is higher. The incorporation of genetic drift also selects for fitness sets that exhibit allele-frequency equilibria with larger domains of attraction: they are "more stable." Moreover, the finiteness of populations strongly influences levels of local adaptation, selection strength, and the proportion of allele-frequency vectors that can be distinguished from the neutral expectation.

show abstract

Gpi genotypic effect on quantitative traits in the northern bay scallop, Argopecten irradians irradians

Krause

Bricelj

1995

Marine Biology

View full text Add to dashboard Cite

The Maintenance of Single-Locus Polymorphism. II. The Evolution of Fitnesses and Allele Frequencies

Cited by 30 publications

References 0 publications

The Generation and Maintenance of Genetic Variation by Frequency-Dependent Selection: Constructing Polymorphisms Under the Pairwise Interaction Model

The Generation and Maintenance of Genetic Variation by Frequency-Dependent Selection: Constructing Polymorphisms Under the Pairwise Interaction Model

Effects of Genetic Drift and Gene Flow on the Selective Maintenance of Genetic Variation

Gpi genotypic effect on quantitative traits in the northern bay scallop, Argopecten irradians irradians

Contact Info

Product

Resources

About