The macrophage migration inhibitory factor (MIF) gene polymorphism in Czech and Russian patients with myocardial infarction

Tereshchenko, I. P.; Petrkova, Jana; Mrázek, František; Lukl, Jan; Maksimov, V. N.; Romaschenko, A. G.; Воевода, М. И.; Petřek, Martin

doi:10.1016/j.cca.2008.12.034

Cited by 24 publications

(22 citation statements)

References 15 publications

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“…The frequencies of AA, AG, and GG genotypes were 9.49 % , 74.05 % , and 16.45 % in the study population. The MIF polymorphism rs1007888 distribution in our study population is similar to other investigations [15] . The observed proportions of MIF genotypes were signifi cantly diff erent in GDM patients and healthy subjects.…”

Section: Results ▼supporting

confidence: 91%

“…The rs1007888 is located on 3 807 bp 3 ′ of the translation termination codon and is distinguished with A and G alleles [14] . Moreover, this variation was common in Czech MI patients compared with healthy individuals [15] .…”

Section: Genetic Variation In Macrophage Migration Inhibitory Factor mentioning

confidence: 99%

“…MIF gene SNP rs1007888 A / G was genotyped by polymerase chain reaction with sequence-specifi c primers (PCR-SSP). The primer sequences were as follows: allele G, reverse primer: 5 ′ GAG AAG TAT CGT CCC CAC C; allele A, reverse primer: 5 ′ GAG AAG TAT CGT CCC CAC T; constant forward primer: 5 ′ AGC CAA GGA GAA TGG GAG AT [15] . The amplifi cation internal control and PCR compounds were described elsewhere [15,16] .…”

Section: Laboratory Measurementsmentioning

confidence: 99%

“…The primer sequences were as follows: allele G, reverse primer: 5 ′ GAG AAG TAT CGT CCC CAC C; allele A, reverse primer: 5 ′ GAG AAG TAT CGT CCC CAC T; constant forward primer: 5 ′ AGC CAA GGA GAA TGG GAG AT [15] . The amplifi cation internal control and PCR compounds were described elsewhere [15,16] . Polymerase chain reaction (PCR) was carried out in a total volume of 20 μ l, including 10 μ l of diluent buff er, 6 μ l of water, 3 μ l (50 ng) genomic DNA, and 0.5 μ l (5 pmol) of each primer.…”

Section: Laboratory Measurementsmentioning

confidence: 99%

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Genetic Variation in Macrophage Migration Inhibitory Factor Associated with Gestational Diabetes Mellitus and Metabolic Syndrome

et al. 2011

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The aim of this study was to investigate the association of macrophage migration inhibitory factor (MIF) polymorphism rs1007888 with gestational diabetes mellitus (GDM), and its association with postpartum metabolic syndrome. In a case-control study, 147 GDM and 169 healthy pregnant patients were recruited. Blood sample was taken 2 times from all the participants; one at 24-28 weeks of gestation, second at 6-12 weeks of postpartum. Biochemical measurement and DNA extraction were performed. The PCR_SSP was performed for genotyping. The frequencies of AA, AG, and GG genotypes were 11.24% (19), 76.92% (130), and 11.83% (20) in healthy pregnancies and were 7.48% (11), 70.74% (104), and 21.76% (32) in GDM individuals. The distributions of MIF genotypes were significantly different in GDM and healthy subjects (p=0.04). Moreover, GG genotype had a significant association with pre-pregnancy obesity and family history of diabetes. In postpartum follow-up GG genotype was two-fold more frequent in women with metabolic syndrome (p=0.01, odds ratio=2.30, CI 95%; 1.23-4.30) and relative risk was equal 1.77 (CI 95%; 1.19-2.64). Our findings demonstrate an association between MIF polymorphism rs1007888 and susceptibility to GDM in pregnancy and metabolic syndrome development.

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Section: Results ▼supporting

confidence: 91%

Section: Genetic Variation In Macrophage Migration Inhibitory Factor mentioning

confidence: 99%

Section: Laboratory Measurementsmentioning

confidence: 99%

Section: Laboratory Measurementsmentioning

confidence: 99%

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Genetic Variation in Macrophage Migration Inhibitory Factor Associated with Gestational Diabetes Mellitus and Metabolic Syndrome

et al. 2011

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“…The rs1007888 locus is located 3807 base pairs towards the 3' end of the translation termination codon and contains the alleles G and A (Herder et al, 2008b). A previous study identified the GG genotype of the MIF SNP rs1007888 was associated with myocardial infarction in Czech female patients (Tereshchenko et al, 2009). Herder et al (2008b) also found that the G allele of the rs1007888 locus was related to the onset of T2D in females, and was closely related to high levels of MIF in the circulation; elevated serum MIF levels were found to be related to an increase in T2D risk, suggesting that MIF has a pathogenic role in T2D.…”

Section: Discussionmentioning

confidence: 99%

Association between macrophage migration inhibitory factor rs1007888 and GDM

Zhan¹,

Li²,

Chen³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. We investigated the association between macrophage migration inhibitory factor (MIF) rs1007888 single-nucleotide polymorphisms and the genetic susceptibility to gestational diabetes mellitus (GDM). A total of 240 GDM pregnant women (GDM group) and 330 healthy pregnant women (control group) were included in the study. Differences in the MIF rs1007888 genotype and allele frequencies and differences between fasting blood glucose, fasting insulin, homeostatic model assessment (HOMA)-insulin resistance, and HOMA-b levels of pregnant women with different genotypes were compared. MIF genotype distributions were significantly different in the GDM group compared to the control group (P < 0.05). No significant difference was observed in the allele distributions of MIF rs1007888 between the GDM group and control group (P > 0.05). GDM patients had higher fasting blood glucose, fasting insulin, and HOMA-insulin resistance levels, but lower HOMA-b levels than normal gestational women (P < 0.05). Fasting blood glucose, fasting insulin, and HOMA-insulin resistance in pregnant women with the GG genotype were significantly higher than those with GA and AA genotypes, while HOMA-b in pregnant women with the GG genotype was lower (all P < 0.05). Our findings demonstrated the associations among MIF polymorphism rs1007888, insulin resistance, and pancreatic β cell functions in GDM patients. The GG genotype of MIF rs1007888 may be a genetic susceptibility factor in the pathogenesis of GDM.

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MIF Family Proteins in Cardiac Ischemia/Reperfusion Injury

Stoppe

Bernhagen

2017

MIF Family Cytokines in Innate Immunity and Homeostasis

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The macrophage migration inhibitory factor (MIF) gene polymorphism in Czech and Russian patients with myocardial infarction

Cited by 24 publications

References 15 publications

Genetic Variation in Macrophage Migration Inhibitory Factor Associated with Gestational Diabetes Mellitus and Metabolic Syndrome

Genetic Variation in Macrophage Migration Inhibitory Factor Associated with Gestational Diabetes Mellitus and Metabolic Syndrome

Association between macrophage migration inhibitory factor rs1007888 and GDM

MIF Family Proteins in Cardiac Ischemia/Reperfusion Injury

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