Association between macrophage migration inhibitory factor rs1007888 and GDM

Zhan, Ying; Li, C; Chen, J; Yu, Shanshan; Gao, Qing; Wang, Y P; Liu, S G

doi:10.4238/2015.february.2.4

Cited by 8 publications

(4 citation statements)

References 24 publications

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“…The macrophage migration inhibitory factor (MIF), is a pro-inflammatory cytokine secreted by T-lymphocytes in response to delayed-type hypersensitivity, which exerts an inhibitory effect on macrophage migration. The rs755622 polymorphism of this gene (MIF-173G/C) is associated with higher GDM risk (OR: 1.59) ( Li et al, 2016 ), and the rs1007888 polymorphism is related to high levels of blood glucose and insulin ( Zhan et al, 2015 ).…”

Section: Genetic Factors Associated With Gestational Diabetes Mellitu...mentioning

confidence: 99%

Pathophysiological Role of Genetic Factors Associated With Gestational Diabetes Mellitus

et al. 2022

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Gestational Diabetes Mellitus (GDM) is a highly prevalent maternal pathology characterized by maternal glucose intolerance during pregnancy that is, associated with severe complications for both mother and offspring. Several risk factors have been related to GDM; one of the most important among them is genetic predisposition. Numerous single nucleotide polymorphisms (SNPs) in genes that act at different levels on various tissues, could cause changes in the expression levels and activity of proteins, which result in glucose and insulin metabolism dysfunction. In this review, we describe various SNPs; which according to literature, increase the risk of developing GDM. These SNPs include: (1) those associated with transcription factors that regulate insulin production and excretion, such as rs7903146 (TCF7L2) and rs5015480 (HHEX); (2) others that cause a decrease in protective hormones against insulin resistance such as rs2241766 (ADIPOQ) and rs6257 (SHBG); (3) SNPs that cause modifications in membrane proteins, generating dysfunction in insulin signaling or cell transport in the case of rs5443 (GNB3) and rs2237892 (KCNQ1); (4) those associated with enzymes such as rs225014 (DIO2) and rs9939609 (FTO) which cause an impaired metabolism, resulting in an insulin resistance state; and (5) other polymorphisms, those are associated with growth factors such as rs2146323 (VEGFA) and rs755622 (MIF) which could cause changes in the expression levels of these proteins, producing endothelial dysfunction and an increase of pro-inflammatory cytokines, characteristic on GDM. While the pathophysiological mechanism is unclear, this review describes various potential effects of these polymorphisms on the predisposition to develop GDM.

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Section: Genetic Factors Associated With Gestational Diabetes Mellitu...mentioning

confidence: 99%

Pathophysiological Role of Genetic Factors Associated With Gestational Diabetes Mellitus

et al. 2022

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“…The macrophage migration inhibitory factor (MIF) gene is positioned at 22q11.23 [62]. Although MIF molecules are not considered to belong to the cytokine family [63], most participate in the critical regulatory functions of macrophage and lymphocyte activation in innate and adaptive immune responses, and the MIF gene has been identified to be a novel candidate gene for T2DM [64]. When MIF levels are attenuated, glucose pathways are improved due to reduced peripheral insulin resistance and the regulatory effects of glucocorticoids [62,65].…”

Section: Genes Involved In Glucose Metabolism and Insulin Resistancementioning

confidence: 99%

“…Further, Yilmaz et al found that serum insulin levels and MIF concentrations in Caucasian women with GDM in Turkey were significantly higher than in healthy control women, suggesting that MIF may play a role in the development of GDM [65]. Studies have shown that fasting blood glucose and insulin levels and insulin resistance in pregnant women with the GG genotype MIF rs1007888 were significantly higher than in pregnant women with other genotypes [63]. The number of rs755622 C allele carriers in GDM women was also significantly higher than in the normal control group, suggesting that this allele may be a risk factor for GDM [64] Aslani et al also found a high frequency of the rs1007888 GG genotype and a significant association with preconception obesity in Indian women with GDM [62].…”

Section: Genes Involved In Glucose Metabolism and Insulin Resistancementioning

confidence: 99%

Gestational Diabetes Mellitus: The Genetic Susceptibility Behind the Disease

Wei

Wang

et al. 2021

Horm Metab Res

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Gestational diabetes mellitus (GDM), a type of pregnancy-specific glucose intolerance or hyperglycemia, is one of the most common metabolic disorders in pregnant women with 16.9% of the global prevalence of gestational hyperglycemia. Not only are women with GDM likely to develop T2DM, but their children are also at risk for birth complications or metabolic disease in adulthood. Therefore, identifying the potential risk factors for GDM is very important in the prevention and treatment of GDM. Previous studies have shown that genetic predisposition is an essential component in the occurrence of GDM. In this narrative review, we describe the role of polymorphisms in different functional genes associated with increased risk for GDM, and available evidence on genetic factors in the risk of GDM is summarized and discussed.

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“…Another MØ secretory signal, a pro-inflammatory cytokine known as MØ migration inhibitory factor (MIF) which stimulates TH1 cells, induces IL-17 release, and increases TLR-4 expression on MØ is used for GDM prediction ( Figure 2C ) ( Yilmaz et al, 2012 ). Moreover, GDM susceptibility has also been determined by specific genotypes associated with MIF ( Aslani et al, 2011 ; Zhan et al, 2015 ). Decreased Treg numbers are associated with GDM prognosis, as shown in multiple studies where subsets of suppressive Tregs, CD4 + CD127LOW+/CD25 + Tregs and CD45RA Tregs were evaluated during GDM pregnancies and represented a decline of anti-inflammatory function of Tregs as early as in the first trimester of GDM pregnancy ( Schober et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Immunological Changes in Pregnancy and Prospects of Therapeutic Pla-Xosomes in Adverse Pregnancy Outcomes

et al. 2022

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Stringent balance of the immune system is a key regulatory factor in defining successful implantation, fetal development, and timely parturition. Interference in these primary regulatory mechanisms, either at adolescence or prenatal state led to adverse pregnancy outcomes. Fertility restoration with the help of injectable gonadotrophins/progesterone, ovulation-inducing drugs, immunomodulatory drugs (corticosteroids), and reproductive surgeries provides inadequate responses, which manifest its own side effects. The development of a potential diagnostic biomarker and an effectual treatment for adverse pregnancy outcomes is a prerequisite to maternal and child health. Parent cell originated bi-layered-intraluminal nano-vesicles (30–150 nm) also known as exosomes are detected in all types of bodily fluids like blood, saliva, breast milk, urine, etc. Exosomes being the most biological residual structures with the least cytotoxicity are loaded with cargo in the form of RNAs (miRNAs), proteins (cytokines), hormones (estrogen, progesterone, etc.), cDNAs, and metabolites making them chief molecules of cell-cell communication. Their keen involvement in the regulation of biological processes has portrayed them as the power shots of cues to understand the disease’s pathophysiology and progression. Recent studies have demonstrated the role of immunexosomes (immunomodulating exosomes) in maintaining unwavering immune homeostasis between the mother and developing fetus for a healthy pregnancy. Moreover, the concentration and size of the exosomes are extensively studied in adverse pregnancies like preeclampsia, gestational diabetes mellitus (GDM), and preterm premature rupture of membrane (pPROMs) as an early diagnostic marker, thus giving in-depth information about their pathophysiology. Exosomes have also been engineered physically as well as genetically to enhance their encapsulation efficiency and specificity in therapy for cancer and adverse pregnancies. Successful bench to bedside discoveries and interventions in cancer has motivated developmental biologists to investigate the role of immunexosomes and their active components. Our review summarizes the pre-clinical studies for the use of these power-shots as therapeutic agents. We envisage that these studies will pave the path for the use of immunexosomes in clinical settings for reproductive problems that arise due to immune perturbance in homeostasis either at adolescence or prenatal state.

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Association between macrophage migration inhibitory factor rs1007888 and GDM

Cited by 8 publications

References 24 publications

Pathophysiological Role of Genetic Factors Associated With Gestational Diabetes Mellitus

Pathophysiological Role of Genetic Factors Associated With Gestational Diabetes Mellitus

Gestational Diabetes Mellitus: The Genetic Susceptibility Behind the Disease

Immunological Changes in Pregnancy and Prospects of Therapeutic Pla-Xosomes in Adverse Pregnancy Outcomes

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