Genetic Variation in Macrophage Migration Inhibitory Factor Associated with Gestational Diabetes Mellitus and Metabolic Syndrome

Aslani, Saeed; Hossein–Nezhad, Arash; Maghbooli, Zhila; Mirzaei, Khadijeh; Karimi, Fatemeh

doi:10.1055/s-0031-1275706

Cited by 17 publications

(13 citation statements)

References 31 publications

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“…Certain roles in macrophage accumulation and inflammatory reactions could be attributed to the proinflammatory cytokine called macrophage migration inhibitory factor, which has pleiotropic immune functions (Nishihira 2000). Migration inhibitory factor concentrations are increased in GDM and its polymorphisms associate with susceptibility to GDM development in pregnancy (Aslani et al 2011, Yilmaz et al 2012. Apart from proinflammatory cytokine production, M1 macrophages represent the potential source of reactive oxide species and nitric oxide (Mantovani et al 2004) that may eventually contribute to the development of adipose tissue (Jang et al 2016) and placental fibrosis Krzyzanowska et al 2006, Lewandowski et al 2007 ↓ (Chan et al 2006, Haider et al 2007 ↑ (Chang et al 2011) -…”

Section: Journal Of Endocrinologymentioning

confidence: 99%

The role of obesity and adipose tissue dysfunction in gestational diabetes mellitus

Šimják

Cinkajzlová

Anderlová

et al. 2018

Journal of Endocrinology

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Gestational diabetes mellitus is defined as diabetes diagnosed in the second or third trimester of pregnancy in patients with no history of diabetes prior to gestation. It is the most common complication of pregnancy. The underlying pathophysiology shares some common features with type 2 diabetes mellitus (T2DM) combining relatively insufficient insulin secretion with increased peripheral insulin resistance. While a certain degree of insulin resistance is the physiological characteristics of the second half of pregnancy, it is significantly more pronounced in patients with gestational diabetes. Adipose tissue dysfunction and subclinical inflammation in obesity are well-described causes of increased insulin resistance in non-pregnant subjects and are often observed in individuals with T2DM. Emerging evidence of altered adipokine expression and local inflammation in adipose tissue in patients with gestational diabetes suggests an important involvement of adipose tissue in its etiopathogenesis. This review aims to summarize current knowledge of adipose tissue dysfunction and its role in the development of gestational diabetes. We specifically focus on the significance of alterations of adipokines and immunocompetent cells number and phenotype in fat. Detailed understanding of the role of adipose tissue in gestational diabetes may provide new insights into its pathophysiology and open new possibilities of its prevention and treatment.

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Section: Journal Of Endocrinologymentioning

confidence: 99%

The role of obesity and adipose tissue dysfunction in gestational diabetes mellitus

Šimják

Cinkajzlová

Anderlová

et al. 2018

Journal of Endocrinology

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“…Furthermore, associations between MIF genotype Rs1007888GG and gestational diabetes as well as pre-pregnancy obesity and family history of diabetes have been reported (55). This specific genotype was also found to be twofold more frequent in women with metabolic syndrome (55). …”

Section: Human Studiesmentioning

confidence: 99%

Role of Macrophage Migration Inhibitory Factor in Obesity, Insulin Resistance, Type 2 Diabetes, and Associated Hepatic Co-Morbidities: A Comprehensive Review of Human and Rodent Studies

Morrison

Kleemann

2015

Front. Immunol.

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Obesity is associated with a chronic low-grade inflammatory state that drives the development of obesity-related co-morbidities such as insulin resistance/type 2 diabetes, non-alcoholic fatty liver disease (NAFLD), and cardiovascular disease. This metabolic inflammation is thought to originate in the adipose tissue, which becomes inflamed and insulin resistant when it is no longer able to expand in response to excess caloric and nutrient intake. The production of inflammatory mediators by dysfunctional adipose tissue is thought to drive the development of more complex forms of disease such as type 2 diabetes and NAFLD. An important factor that may contribute to metabolic inflammation is the cytokine macrophage migration inhibitory factor (MIF). Increasing evidence suggests that MIF is released by adipose tissue in obesity and that it is also involved in metabolic and inflammatory processes that underlie the development of obesity-related pathologies. This review provides a comprehensive summary of our current knowledge on the role of MIF in obesity, its production by adipose tissue, and its involvement in the development of insulin resistance, type 2 diabetes, and NAFLD. We discuss the main findings from recent clinical studies in obese subjects and weight-loss intervention studies as well as results from clinical studies in patients with insulin resistance and type 2 diabetes. Furthermore, we summarize findings from experimental disease models studying the contribution of MIF in obesity and insulin resistance, type 2 diabetes, and hepatic lipid accumulation and fibrosis. Although many of the findings support a pro-inflammatory role of MIF in disease development, recent reports also provide indications that MIF may exert protective effects under certain conditions.

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“…The PCR amplification primers were designed based on relevant literature (Aslani et al, 2011) and the original DNA sequence reported in GenBank. Primer synthesis was performed by Shanghai Sunny Biotechnology Co., Ltd. (Shanghai, China).…”

Section: Detection Of Mif Rs1007888 Polymorphismmentioning

confidence: 99%

“…Macrophage migration inhibitory factor (MIF) is a protein that can function as a cytokine, hormone, or enzyme and exhibits a variety of biological activities, playing an important role in inflammation and immunity (Grieb et al, 2010). Previous studies have shown that MIF is related to the occurrence of obesity and insulin resistance syndromes (Finucane et al, 2012), and MIF gene polymorphisms have been correlated with GDM and metabolic syndromes (Aslani et al, 2011). To further validate the genetic susceptibility to GDM based on MIF gene polymorphisms, we used polymerase chain reaction (PCR) and DNA direct sequencing technology to analyze the MIF rs1007888 locus.…”

Section: Introductionmentioning

confidence: 99%

Association between macrophage migration inhibitory factor rs1007888 and GDM

Zhan¹,

Li²,

Chen³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. We investigated the association between macrophage migration inhibitory factor (MIF) rs1007888 single-nucleotide polymorphisms and the genetic susceptibility to gestational diabetes mellitus (GDM). A total of 240 GDM pregnant women (GDM group) and 330 healthy pregnant women (control group) were included in the study. Differences in the MIF rs1007888 genotype and allele frequencies and differences between fasting blood glucose, fasting insulin, homeostatic model assessment (HOMA)-insulin resistance, and HOMA-b levels of pregnant women with different genotypes were compared. MIF genotype distributions were significantly different in the GDM group compared to the control group (P < 0.05). No significant difference was observed in the allele distributions of MIF rs1007888 between the GDM group and control group (P > 0.05). GDM patients had higher fasting blood glucose, fasting insulin, and HOMA-insulin resistance levels, but lower HOMA-b levels than normal gestational women (P < 0.05). Fasting blood glucose, fasting insulin, and HOMA-insulin resistance in pregnant women with the GG genotype were significantly higher than those with GA and AA genotypes, while HOMA-b in pregnant women with the GG genotype was lower (all P < 0.05). Our findings demonstrated the associations among MIF polymorphism rs1007888, insulin resistance, and pancreatic β cell functions in GDM patients. The GG genotype of MIF rs1007888 may be a genetic susceptibility factor in the pathogenesis of GDM.

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Genetic Variation in Macrophage Migration Inhibitory Factor Associated with Gestational Diabetes Mellitus and Metabolic Syndrome

Cited by 17 publications

References 31 publications

The role of obesity and adipose tissue dysfunction in gestational diabetes mellitus

The role of obesity and adipose tissue dysfunction in gestational diabetes mellitus

Role of Macrophage Migration Inhibitory Factor in Obesity, Insulin Resistance, Type 2 Diabetes, and Associated Hepatic Co-Morbidities: A Comprehensive Review of Human and Rodent Studies

Association between macrophage migration inhibitory factor rs1007888 and GDM

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