The light subunit of mushroom Agaricus bisporus tyrosinase: Its biological characteristics and implications

Ismaya, Wangsa T.; Tandrasasmita, Olivia Mayasari; Sundari, Syaripah; [], Diana; Lai, Xuelei; Retnoningrum, Debbie Soefie; Dijkstra, Bauke W.; Tjandrawinata, Raymond R.; Rachmawati, Heni

doi:10.1016/j.ijbiomac.2017.04.014

Cited by 23 publications

(26 citation statements)

References 75 publications

(51 reference statements)

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“…Mushroom tyrosinase from Agaricus bisporus is a major and cheap enzyme, with high similarity and homology compared to human tyrosinase [1,37,38]. Due to the above-mentioned good properties, the structural, functional, and biochemical characteristics of mushroom tyrosinase have been studied extensively as a model system for screening of tyrosinase inhibitors and melanogenic studies, enzyme-catalyzed reactions, and enzyme-inhibitor structural studies so far [1,[39][40][41]. Tyrosinase from A. bisporus is a 120 kDa tetramer, which was first isolated by Bourquelot and Bertrand in 1895 [42].…”

Section: Tyrosinase and Its Key Role In Melanin Synthesismentioning

confidence: 99%

Natural and Bioinspired Phenolic Compounds as Tyrosinase Inhibitors for the Treatment of Skin Hyperpigmentation: Recent Advances

2019

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One of the most common approaches for control of skin pigmentation involves the inhibition of tyrosinase, a copper-containing enzyme which catalyzes the key steps of melanogenesis. This review focuses on the tyrosinase inhibition properties of a series of natural and synthetic, bioinspired phenolic compounds that have appeared in the literature in the last five years. Both mushroom and human tyrosinase inhibitors have been considered. Among the first class, flavonoids, in particular chalcones, occupy a prominent role as natural inhibitors, followed by hydroxystilbenes (mainly resveratrol derivatives). A series of more complex phenolic compounds from a variety of sources, first of all belonging to the Moraceae family, have also been described as potent tyrosinase inhibitors. As to the synthetic compounds, hydroxycinnamic acids and chalcones again appear as the most exploited scaffolds. Several inhibition mechanisms have been reported for the described inhibitors, pointing to copper chelating and/or hydrophobic moieties as key structural requirements to achieve good inhibition properties. Emerging trends in the search for novel skin depigmenting agents, including the development of assays that could distinguish between inhibitors and potentially toxic substrates of the enzyme as well as of formulations aimed at improving the bioavailability and hence the effectiveness of well-known inhibitors, have also been addressed.

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Section: Tyrosinase and Its Key Role In Melanin Synthesismentioning

confidence: 99%

Natural and Bioinspired Phenolic Compounds as Tyrosinase Inhibitors for the Treatment of Skin Hyperpigmentation: Recent Advances

2019

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“…Recently, a protein with a lectin-like structure was discovered [22] and named Abmb [37]. Interestingly, Abmb displays biological activities similar to lectins [20,38]. Abmb also has therapeutic potential [38]; hence, it is included in this review.…”

Section: Lectins and Lectin-like Protein In A Bisporusmentioning

confidence: 99%

Lectins from the Edible Mushroom Agaricus bisporus and Their Therapeutic Potentials

Ismaya¹,

Tjandrawinata²,

Rachmawati

2020

Molecules

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The mushroom Agaricus bisporus secretes biologically active compounds and proteins with benefits for human health. Most reported proteins from A. bisporus are tyrosinases and lectins. Lectins are of therapeutic or pharmaceutical interest. To date, only limited information is available on A. bisporus lectins and lectin-like proteins. No therapeutic products derived from A. bisporus lectin (ABL) are available on the market despite its extensive exploration. Recently, A. bisporus mannose-binding protein (Abmb) was discovered. Its discovery enriches the information and increases the interest in proteins with therapeutic potential from this mushroom. Furthermore, the A. bisporus genome reveals the possible occurrence of other lectins in this mushroom that may also have therapeutic potential. Most of these putative lectins belong to the same lectin groups as ABL and Abmb. Their relationship is discussed. Particular attention is addressed to ABL and Abmb, which have been explored for their potential in medicinal or pharmaceutical applications. ABL and Abmb have anti-proliferative activities toward cancer cells and a stimulatory effect on the immune system. Possible scenarios for their use in therapy and modification are also presented.

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“…Although human tyrosinase can be isolated from melanomas [ 6 , 7 , 8 ], well-defined preparations of recombinant hTyr with activities sufficient for large-scale inhibition studies have become available only in recent years [ 9 , 10 , 11 ]. Moreover, in the last decade, several X-ray structures of tyrosinases and tyrosinase-like proteins have been published, including mTyr [ 12 , 13 ], bacterial tyrosinases from Streptomyces castaneoglobisporus (sTyr, [ 14 ]) and Bacillus megaterium (bTyr, [ 15 ]), respectively, and, most recently, the human tyrosinase-related protein 1 (hTrp1), a melanogenic protein of yet unknown function in humans [ 16 ]. Common structural features of these proteins have been reviewed by several authors [ 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Structure-Activity Relationships of Thiazolyl Resorcinols, Potent and Selective Inhibitors of Human Tyrosinase

Mann

Scherner

Röhm

et al. 2018

IJMS

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Tyrosinase inhibitors are of great clinical interest as agents for the treatment of hyperpigmentary disorders; however, most compounds described in the literature lack clinical efficiency due to insufficient inhibitory activity against human tyrosinase (hTyr). Recently, we reported that thiazolyl resorcinols (4-resorcinylthiazol-2-amines and -amides) are both selective and efficacious inhibitors of hTyr in vitro and in vivo. Here, we measured dose-activity profiles of a large number of thiazolyl resorcinols and analogous compounds to better understand the molecular basis of their interaction with hTyr. We show that both the resorcinyl moiety and the thiazole ring must be intact to allow efficient inhibition of hTyr, while the substituents at the thiazole 2-amino group confer additional inhibitory activity, depending on their size and polarity. The results of molecular docking simulations were in excellent agreement with the experimental data, affording a rationale for the structural importance of either ring. We further propose that a special type of interaction between the thiazole sulfur and a conserved asparagine residue is partially responsible for the superior inhibitory activity of thiazolyl resorcinols against hTyr.

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The light subunit of mushroom Agaricus bisporus tyrosinase: Its biological characteristics and implications

Cited by 23 publications

References 75 publications

Natural and Bioinspired Phenolic Compounds as Tyrosinase Inhibitors for the Treatment of Skin Hyperpigmentation: Recent Advances

Natural and Bioinspired Phenolic Compounds as Tyrosinase Inhibitors for the Treatment of Skin Hyperpigmentation: Recent Advances

Lectins from the Edible Mushroom Agaricus bisporus and Their Therapeutic Potentials

Structure-Activity Relationships of Thiazolyl Resorcinols, Potent and Selective Inhibitors of Human Tyrosinase

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