The large increase in incidence of Type I diabetes mellitus in Poland

Krętowski, Adam; Kowalska, Irina; Peczyńska, Jadwiga; Urban, Mirosława; Green, A.; Kinalska, I

doi:10.1007/pl00002954

Cited by 21 publications

(19 citation statements)

References 2 publications

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“…The number of new cases has tripled over the observed period 1989–2002, whereas at the same time, the number of children (background population) has decreased by more than 20%. Reports from other regions of Poland and from other neighboring countries confirm our observations (15–17). At present, the only prospective register of Polish children affected by DMT1 is our Upper Silesian database, which continued from 1989 as a part of EURODIAB program.…”

Section: Discussionsupporting

confidence: 86%

Does social–economical transformation influence the incidence of type 1 diabetes mellitus? A Polish example

2008

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Currently, Poland and its part, Upper Silesia, belong to regions with high DMT1 incidence in children. The change from low to high incidence of DMT1 over the past 14 yr corresponded to profound social and economical transformations. Our observations confirm the importance of environmental factors in the aetiopathogenesis of DMT1. The state of hygiene and the state of the health of the society influence its susceptibility to DMT1.

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Section: Discussionsupporting

confidence: 86%

Does social–economical transformation influence the incidence of type 1 diabetes mellitus? A Polish example

2008

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“…However, the frequency of GADA in our AAD cohort exceeds their 15.5% rate in another well-established T1DM risk group, i.e. first degree relatives of affected Polish children [29]. In our study, aIA2 were found exclusively in diabetic AAD patients, IAA-mostly in diabetics (three of four positive results), while GADA were detectable in 4/6 (66.7%) T1DM ?…”

Section: Discussionmentioning

confidence: 67%

Screening for associated autoimmune disorders in Polish patients with Addison’s disease

Fichna

Gryczyńska

et al. 2010

Endocr

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Autoimmune Addison's disease (AAD) is the main reason of primary adrenal failure. More than a half of patients display additional autoimmune conditions, which represent a considerable clinical concern. This study aimed to investigate the prevalence of concomitant autoimmune disorders in 85 Polish AAD patients (61 females, 24 males). Mean age at AAD onset was 34.6 ± 12.6 years, significantly earlier in males (P < 0.001). Sixty-nine patients presented positive serum antibodies to 21-hydroxylase and shorter AAD duration than those with negative results (P = 0.027). Seventy-three subjects suffered from coexisting autoimmune disorders. Serum autoantibodies against thyreoperoxidase, thyroglobulin, TSH receptor, glutamic acid decarboxylase, insulin, tyrosine phosphatase-like protein IA2, parietal cell H(+)/K(+)-ATPase, intrinsic factor and tissue transglutaminase were detectable in 71.8, 41.2, 4.7, 21.0, 4.9, 2.5, 49.4, 12.0 and 3.5% of patients, respectively. Antinuclear antibodies were found in 12.5%. Thyroid autoimmunity was most common (46 subjects with lymphocytic thyroiditis, 19 with Graves' disease), followed by atrophic gastritis (29.4%), pernicious anaemia (11.8%), hypergonadotropic hypogonadism (8.2%), vitiligo (8.2%), type 1 diabetes (7.1%), celiac disease (3.5%) and alopecia (2.4%). Gender differences were observed only for thyroid autoimmunity. Current study confirms particular tendency of AAD patients to develop other autoimmune disorders. Active search for concomitant conditions is warranted to prevent serious complications.

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“…1, 2, 3 Accordingly, also in Poland in the last decade, a significant increase in type I diabetes mellitus (T1DM) incidence has been reported for the paediatric population. 4, 5, 6 Along with increased incidence of diabetes, the risk of development of diabetic microvascular complications, as well as the percentage of patients with arterial hypertension (HT), has also increased. 7, 8, 9 According to various estimations, 1–5% of children have HT.…”

Section: Introductionmentioning

confidence: 99%

Association between vascular endothelial growth factor and hypertension in children and adolescents type I diabetes mellitus

et al. 2010

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The aim of the study was to analyse the relationship between the serum level of vascular endothelial growth factor (VEGF) and the incidence of hypertension (HT) in children and adolescents with type I diabetes mellitus (T1DM). One hundred and five patients with T1DM were enrolled in the study. The control group consisted of 30 healthy controls. All the T1DM patients were subjected to biochemical analyses, ophthalmologic examination and 24-h blood pressure monitoring. Besides, all the patients and healthy controls had serum VEGF levels measured with the use of the ELISA methodology. The essence of our research is that patients with T1DM and HT and with microalbuminuria (MA) and diabetic retinopathy (DR) (MA/DR) are characterized by a significantly higher level of VEGF (340.23±93.22 pg ml–1) in blood serum in comparison with the group of T1DM patients without HT and MA/DR (183.6±96.6 pg ml–1) and with healthy controls (145.32±75.58 pg ml–1). In addition, the VEGF level was significantly higher in T1DM patients, who presented all three complications, that is HT, retinopathy and MA in comparison with T1DM patients without HT, but with MA/DR (P=0.036). On the other hand, no statistically significant differences (P=0.19) were noted in the level of VEGF in serum between T1DM patients without HT and MA/DR and the healthy control group. At a further stage of analysis, using the method of multiple regression, it was shown that systolic pressure, HbA1c and duration of disease are independent factors influencing the concentration of VEGF. Summarizing, the measurement of VEGF serum levels allows for the identification of groups of patients who have the highest risk of HT and, subsequently, progression of vascular complications.

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The large increase in incidence of Type I diabetes mellitus in Poland

Cited by 21 publications

References 2 publications

Does social–economical transformation influence the incidence of type 1 diabetes mellitus? A Polish example

Does social–economical transformation influence the incidence of type 1 diabetes mellitus? A Polish example

Screening for associated autoimmune disorders in Polish patients with Addison’s disease

Association between vascular endothelial growth factor and hypertension in children and adolescents type I diabetes mellitus

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