The Investigation of the Development of a Cream Composition With the Sapropel Extract

Abstract

Objective: The objective of this research was the development of cream with sapropel extract on the emulsifying base and the investigation of the possibility for cream samples to be in future applied in medicine, cosmetics, and veterinary.Methods: To carry out the research a set of methods (centrifugal, thermal, and potentiometric) to analyze colloidal and thermal stability and determine pH values of the tested samples were used. Organoleptic characteristics of the tested samples and possible signs of physical instability were studied. Rheological properties of the samples were determined on the rotating viscometer. The method of microscopic analysis was carried out to analyze the stability of the emulsion system.Results: The research outcomes revealed that all the prototype samples have thermal and colloid stability, neutral pH value, and consistency that depends on the content of the oil phase and the emulsifying mixture. The samples, containing 15% of Vaseline oil and 4% and 6% of emulsifier no. 1, have low viscosity indexes, and the sample with 10% of emulsifier has a rather dense consistency. The samples containing 20% of oil phase possess unsatisfactory organoleptic properties. Since the sample with 4% of emulsifier possessed low rates of viscosity and phase separation occurred during its storage.Microscopic studies have shown that the sample containing 6% of emulsifier no. 1 exhibits monodisperse and a uniform roundness of drops that indicates the stability of the system.Conclusion: The outcome of the research is the development of the composition of the cream with sapropel extract with the emulsifying base containing 15% of corn oil, 6% of emulsifier no. 1, and 1% of Cetostearyl alcohol and purified water.

Development of methods of identification and quantitative determination of active substances in semi-solid dosage forms with sapropel extracts

“…Test samples of emulsion cream type o/v, containing 15 % aqueous extract of sapropel (AES) and 10 % oily extract of sapropel (OES), 6 % emulsifier No. 1, 1 % cetylstearyl alcohol, preservatives -0.01 % nisin, 0.1 % euksil K 100 and purified water up to 100 g [14], were made by phase inversion by the following technology: the aqueous phase (purified water, AES, preservatives) was heated to a temperature of 70 ± 5 °C and added to the oil phase (OES, emulsifier No. 1, cetylstearyl alcohol).…”

“…The total mass fraction of humic acids (HA) was determined by the method described in the literature, after oxidation of HA by the method of I. V. Tyurin in the modification of B. A. Nikitin and titration with Mohr's salt [14].…”

“…For use in veterinary medicine for the treatment of wound process and prevention of mastitis, we have developed an emulsion-based cream, tentatively called «Saprocream», containing 15 % sapropel oil extract (OES) and 10 % aqueous sapropel extract (AES) [14].…”

Justification of technological parameters of the cream production with sapropel extract

“…(Klöcking and Helbig 2005;Strus et al 2014, Strus 2015c. During our previous investigations of test samples of the cream with sapropel extract, there was worked out the o/w emulsion base,containing 15% corn oil, 6% emulgator no.1 (Lanette SX), 1% cetylstearyl alcohol (CSA), 0.01% nisin, 0.1% euxyl K 100 and purified water to 100 g (Strus et al 2018(Strus et al , 2019.…”

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“…In accordance with investigated organoleptic and consumer properties, thermal and colloidal stability, pH values, structural and mechanical characters of prototype samples, for further experiments concerning development of composition of a cream with sapropel extract was selected the emulsifying base containing 15% of corn oil, 6% of emulsifier No.1 (Lanette SX), 1% of cetostearyl alcohol and purified water. [7] The following materials were employed: Extract of sapropel from Prybych deposits, located in Volyn region; emulsion base, containing 15% corn oil, 6% emulsifier №1 (Lanette SX, mixture of cetearyl alcohol, sodium lauryl sulfate, and sodium cetearyl sulfate), 1% cetyl stearyl alcohol, and purified water to 100 g.…”