Non-alcoholic fat liver disease (NAFLD) is an urgent problem of modern healthcare and ranks first among all liver diseases worldwide, assuming the nature of an epidemic. The pathogenesis of NAFLD is complex and insufficiently studied, and therefore pharmacological therapy is not always effective and causes negative side effects (or complications). Treatment with mineral waters (MW) is one of the most effective methods of treating diseases of the digestive system and metabolic disorders. Objective: to study the effect of sulphate MW on metabolic disturbances in rats with the experimental NAFLD model for the purpose of scientifically substantiating its use in the complex of treatment of patients. Morphological studies have established that the use of sulfate MW in healthy animals causes an increase in the functional activity of the liver and stomach, which indicates a pronounced biologic activity of this MW. In animals under the influence of sulphate MW was determined a significant reduction in hepatic steatosis according to the morphological study of biopsy specimens, restoration of the processes of bile formation and bile secretion, positive dynamics in the restoration of energy-dependent transmembrane ion transport. Clinical studies in the complex treatment of NAFLD with the use of sulphate MW established normalization of lipid metabolism, improvement of the functional state of the liver, decreased insulin resistance, recovery of adiponectin secretion.
Background. We have previously shown that the Entropy (E) of the relative spectral power density (SPD) of the EEG rhythms is its quite relevant parameter. We also found significant relationships between the SPD E of individual EEG loci and the E of the Leukocytogram (LCG) and Immunocytogram (ICG) of the blood, as well as with their individual components. The purpose of this study was to clarify the relationships between E(s) of these four morphofunctional immune subsystem and sex as well as parameters of the neuroendocrine-immune complex in rats. Materials and methods. Experiment was performed on 108 healthy Wistar rats (48 male and 60 female) weighing 205-300 g (M±SD=260±26 g) divided into 8 groups. Animals of the first group remained intact, using tap water from drinking ad libitum. Instead, the other rats received various balneofactors for 6 days. The day after the completion of the drinking/application course in all rats the parameters of neuroendocrine-immune complex were registered. Results. The drinking/application course did not affect the E level of any morphofunctional immune subsystem, the relationships between which are insignificant. Females have less E TCG than males, whereas sexual dimorphism is insignificant for E SCG and ICG and absent for E LCG. The canonical correlation of mediocre force (R=0,675) between sex index (M=1;F=2) and neuro-endocrine parameters (HRV, calcitonin, parathyroid and mineralocorticoid
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