The International Natural Product Sciences Taskforce (INPST) and the power of Twitter networking exemplified through #INPST hashtag analysis

Singla, Rajeev K.; De, Ronita; Efferth, Thomas; Mezzetti, Bruno; Uddin, Md. Sahab; Sanusi, .; Ntie‐Kang, Fidele; Wang, Dongdong; Schultz, Fabien; Kharat, Kiran; Devkota, Hari Prasad; Battino, Maurizio; Sur, Daniel; Lordan, Ronan; Patnaik, Sourav S.; Tsagkaris, Christos; Sai, Chandragiri Siva; Tripathi, Surya Kant; Găman, Mihnea‐Alexandru; Ahmed, Mohammed E; González-Burgos, Elena; Babiaka, Smith B.; Paswan, Shravan Kumar; Odimegwu, Joy Ifunanya; Akram, Faizan; Simal‐Gándara, Jesús; Urquiza, Mágali S.; Tikhonov, Aleksei; Mondal, Himel; Singla, Shailja; Lonardo, Sara Di; Mulholland, Eoghan J.; Cenanovic, Merisa; Maigoro, Abdulkadir Yusif; Giampieri, Francesca; Lee, Soojin; Tzvetkov, Nikolay; Louka, Anna Maria; Verma, Pritt; Chopra, Hitesh; Olea, Scarlett Perez; Khan, Johra; Álvarez-Suarez, José M.; Zheng, Xiaonan; Tomczyk, Michał; Sabnani, Manoj K; Medina, Christhian Delfino Villanueva; Khalid, Garba M.; Boyina, Hemanth Kumar; Georgiev, Milen I.; Supuran, Claudiu T.; Sobarzo‐Sánchez, Eduardo; Fan, Tai-Ping; Pittalà, Valeria; Sureda, Antoni; Braidy, Nady; Russo, Gian Luigi; Vacca, Rosa Anna; Banach, Maciej; Lizard, Gérard; Zarrouk, Amira; Hammami, S.; Orhan, İlkay Erdoğan; Aggarwal, Bharat B.; Perry, George; Miller, Mark JS; Heinrich, Michael; Bishayee, Anupam; Kijjoa, Anake; Arkells, Nicolas; Bredt, David S.; Wink, Michaël; Fiebich, Bernd L.; Gangarapu, Kiran; Yeung, Andy Wai Kan; Gupta, Girish Kumar; Santini, Antonello; Lucarini, Massimo; Durazzo, Alessandra; El-Demerdash, Amr; Dinkova‐Kostova, Albena T.; Cifuentes, Alejandro; Souto, Eliana B.; Zubair, Muhammad; Badhe, Pravin; Echeverría, Javier; Horbańczuk, J.O.; Horbańczuk, Olaf K.; Sheridan, Helen; Sheshe, Sadeeq Muhammad; Witkowska, Anna; Abu‐Reidah, Ibrahim M.; Riaz, Muhammad Naveed; Ullah, Hammad; Oladipupo, Akolade R.; López, Víctor; Sethiya, Neeraj Kumar; Shrestha, Bhupal Govinda; Ravanan, Palaniyandi; Gupta, Subash C.; Alzahrani, Qushmua; Preethidan, D.S.; Xiao, Jianbo; Moosavi, Mohammad Amin; Subramani, Parasuraman Aiya; Singh, Amit Kumar; Chettupalli, Ananda Kumar; Patra, Jayanta Kumar; Singh, Rajesh; Karpiński, Tomasz M.; Al‐Rimawi, Fuad; Abiri, Rambod; Ahmed, Atallah F.; Barreca, Davide; Vats, Sharad; Amrani, Saïd; Fimognari, Carmela; Mocan, Andrei; Hrițcu, Lucian; Semwal, Prabhakar; Rahaman, Md. Shiblur; Emerald, Mila; Akinrinde, Akinleye Stephen; Singh, Abhilasha; Joshi, Ashima; Joshi, Tanuj; Khan, Shafaat Yar; Adam, Gareeballah Osman; Lu, Aiping; Pai, Sandeep R.; Ghzaiel, Imen; Acar, Niyazi; Es-Safi, Nour Eddine; Zengin, Gökhan; Kureshi, Azazahemad A.; Sharma, Arvind K.; Baral, Bikash; Rani, Neeraj; Jeandet, Philippe; Gulati, Monica; Kapoor, Bhupinder; Mohanta, Yugal Kishore; Emam‐Djomeh, Zahra; Onuku, Raphael; Depew, Jennifer R.; Atrooz, Omar M.; Goh, Bey Hing; Andrade, José Carlos; Konwar, Bikramjit; Shine, V. J.; Dias-Ferreira, João; Ahmad, Jamil; Chaturvedi, Vivek K.; Skalicka-Woźniak, Krystyna; Sharma, Rohit; Gautam, Rupesh K.; Granica, Sebastian; Parisi, Salvatore; Kumar, Rishabh; Atanasov, Atanas G.; Shen, Bairong

doi:10.1016/j.phymed.2022.154520

Cited by 29 publications

(27 citation statements)

References 149 publications

(141 reference statements)

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“…Natural products are a sustainable bioresource with the potential to treat cancer. Many efforts, such as nanotechnology, the integrated study approach and network, have been devoted to developing effective natural medicines [ 4 , 36 ]. However, the delivery of natural anticancer drugs faces great challenges due to limited in vivo kinetic behaviors and poor tumor accumulation.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, the undesirable side effects and toxicity of chemotherapeutic drugs have given rise to damage to patients [ 2 ]. Nutraceuticals are intensively investigated in cancer and chronic diseases, and these natural products offer new possibilities for tumor therapies to overcome the shortcomings of traditional chemotherapeutic treatment [ 3 , 4 , 5 ]. Curcumin (CUR), a curcuminoid extracted from the rhizomes of Curcuma longa , has several advantages, such as strong anticancer effects and outstanding safety [ 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Curcumin-Loaded Platelet Membrane Bioinspired Chitosan-Modified Liposome for Effective Cancer Therapy

Wan

Fan

et al. 2023

Pharmaceutics

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Cancer is a serious threat to human health, and chemotherapy for cancer is limited by severe side effects. Curcumin (CUR) is a commonly used natural product for antitumor treatment without safety concerns. However, low bioavailability and poor tumor accumulation are great obstacles for its clinical application. Our previous research has demonstrated that platelet membrane-camouflaged nanoparticles can efficiently ameliorate the in vivo kinetic characteristics and enhance the tumor affinity of payloads. Nevertheless, the antitumor efficiency of this formulation still needs to be thoroughly investigated, and its drug release behavior is limited. Herein, CUR-loaded platelet membrane bioinspired chitosan-modified liposome (PCLP-CUR) was constructed to improve CUR release. PCLP-CUR was shown to have long retention time, improved bioavailability, strong tumor targeting capacity and effective cellular uptake. The incorporation of chitosan enabled PCLP-CUR to release cargoes quickly under mild acidic tumor conditions, leading to more complete drug release and favoring subsequent treatment. Both in vitro and in vivo investigations showed that PCLP-CUR could significantly enhance the anticancer efficacy of CUR with minimal side effects through biomimetic membrane and chitosan modification. In summary, this developed delivery system can provide a promising strategy for tumor-targeting therapy and phytochemical delivery.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Curcumin-Loaded Platelet Membrane Bioinspired Chitosan-Modified Liposome for Effective Cancer Therapy

Wan

Fan

et al. 2023

Pharmaceutics

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“…Currently herbs and medicinal plant-based products are gaining significant attention worldwide via several advertising media claiming safe and effective due to long and past historical traditional background of traditional clinical applications [27][28][29][30][31] . Here, we presented similar study on an underutilized traditional plant i.e., A. wallichii (Himalayan onion) having wide utility and popularity in ethnomedicine for nutrition, prevention, and treatment of health several related issue [8] .…”

Section: Discussionmentioning

confidence: 99%

TLC and Nutritional Composition Analysis of Allium wallichii Kunth (Himalayan Onion)

Rana¹,

Sethiya²,

Chaudhary³

et al. 2022

J Phytopharmacol

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Allium wallichii (A. wallichii) Kunth, is an underutilized rare medicinal plant species with several beneficial ethnomedicinal health promotion activity Moreover, being so popular in both ethanobotanicals and traditional herbal system, still the plant is very less studied for phytochemical and nutritional composition analysis. Therefore, phytochemical and nutritional composition analysis of A. wallichii leaves are set as the main objective of the current work. In this context powder of A. wallichii leaves was subjected for the nutritional analysis and the extract was subjected to thin layer chromatography analysis for fingerprinting of various compounds. In this context, we have found presence of several health promoting nutraceutical bioactives and phytochemicals compounds. In conclusion the traditional utilization of plant in ethnomedicine for nutraceutical and medicinal purpose was attributed due to presence of nutraceutical bioactives and phytochemicals compounds.

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“…Besides, the cost of contemporary pharmaceuticals is high, and have several unfavorable side effects. ,, Indeed, there is an increasing need for the development of safer, effective, multitargeted, and cost-effective therapeutic regimens to replace the current harmful and ineffective treatment approaches. A growing body of preclinical and clinical evidence suggests that natural substances derived from diverse plants are potential therapeutic candidates against a wide range of fatal chronic conditions, and their alternative formulations can be employed to boost the bioavailabilities of these substances. ,,,− …”

Section: Introductionmentioning

confidence: 99%

Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?

et al. 2023

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Curcumin has been credited with a wide spectrum of pharmacological properties for the prevention and treatment of several chronic diseases such as arthritis, autoimmune diseases, cancer, cardiovascular diseases, diabetes, hemoglobinopathies, hypertension, infectious diseases, inflammation, metabolic syndrome, neurological diseases, obesity, and skin diseases. However, due to its weak solubility and bioavailability, it has limited potential as an oral medication. Numerous factors including low water solubility, poor intestinal permeability, instability at alkaline pH, and fast metabolism contribute to curcumin’s limited oral bioavailability. In order to improve its oral bioavailability, different formulation techniques such as coadministration with piperine, incorporation into micelles, micro/nanoemulsions, nanoparticles, liposomes, solid dispersions, spray drying, and noncovalent complex formation with galactomannosides have been investigated with in vitro cell culture models, in vivo animal models, and humans. In the current study, we extensively reviewed clinical trials on various generations of curcumin formulations and their safety and efficacy in the treatment of many diseases. We also summarized the dose, duration, and mechanism of action of these formulations. We have also critically reviewed the advantages and limitations of each of these formulations compared to various placebo and/or available standard care therapies for these ailments. The highlighted integrative concept embodied in the development of next-generation formulations helps to minimize bioavailability and safety issues with least or no adverse side effects and the provisional new dimensions presented in this direction may add value in the prevention and cure of complex chronic diseases.

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The International Natural Product Sciences Taskforce (INPST) and the power of Twitter networking exemplified through #INPST hashtag analysis

Cited by 29 publications

References 149 publications

Curcumin-Loaded Platelet Membrane Bioinspired Chitosan-Modified Liposome for Effective Cancer Therapy

Curcumin-Loaded Platelet Membrane Bioinspired Chitosan-Modified Liposome for Effective Cancer Therapy

TLC and Nutritional Composition Analysis of Allium wallichii Kunth (Himalayan Onion)

Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?

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