The interconnected role of chemokines and estrogen in bone metabolism

Xu, Yuping; Chu, Nan; Gober, Hans-Jürgen; Li, Da‐Jin; Wang, Ling

doi:10.5582/bst.2016.01072

Cited by 14 publications

(9 citation statements)

References 107 publications

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“…In addition, tumor cells secrete many chemoattractants that promote the migratory activity of MSCs and MSCs express receptors of the four chemokine subfamilies: CC, CXC, CX(3)C and C [49]. It should be born in mind that several chemotaxis assays in vitro have shown that Dose-dependent migration of MSCs could be induced by chemokines like CCL2/MCP1 (monocyte chemoattractant protein-1), CCL25 (thymus expressed chemokine), CXCL8 (IL8), CXCL12/SDF1α and CXCL13 (BCA1) [50]. In addition, sphingosine 1 phosphate (S1P) exerted a strong chemoattraction on MSCs through matrix metalloproteinase (MMP)-mediated signaling events and the RhoA/ROCK and MEK1/ERK intracellular pathways [51].…”

Section: Recruitment Of Mscsmentioning

confidence: 99%

Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment

Elmahallawy

Mohamed

Abdo

et al. 2020

IJMS

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Hepatocellular carcinoma (HCC) is the most common hepatobiliary malignancy with limited therapeutic options. On the other hand, melatonin is an indoleamine that modulates a variety of potential therapeutic effects. In addition to its important role in the regulation of sleep–wake rhythms, several previous studies linked the biologic effects of melatonin to various substantial endocrine, neural, immune and antioxidant functions, among others. Furthermore, the effects of melatonin could be influenced through receptor dependent and receptor independent manner. Among the other numerous physiological and therapeutic effects of melatonin, controlling the survival and differentiation of mesenchymal stem cells (MSCs) has been recently discussed. Given its controversial interaction, several previous reports revealed the therapeutic potential of MSCs in controlling the hepatocellular carcinoma (HCC). Taken together, the intention of the present review is to highlight the effects of melatonin and mesenchymal stem cells as a key for functional integrity for liver cancer treatment. We hope to provide solid piece of information that may be helpful in designing novel drug targets to control HCC.

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Section: Recruitment Of Mscsmentioning

confidence: 99%

Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment

Elmahallawy

Mohamed

Abdo

et al. 2020

IJMS

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“…Prevention of bone remodeling by estrogens is a result of osteoclastogenesis prevention from marrow precursors, as well as of induction of the Fas/FasL system that enhances osteoclast apoptosis [ 44 , 45 ]. Estrogens lead to a further inhibition in bone resorption through effects on the receptor activator of nuclear factor-Kappa B (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) system and the production of some pro-resorptive cytokines (e.g., IL-1, IL-6, IL-7, TNF) [ 46 – 52 ]. Moreover, estrogens directly affect osteoblastic cells contributing to bone preservation [ 53 , 54 ].…”

Section: Discussionmentioning

confidence: 99%

Does exogenous female sex hormone administration affect the rate of tooth movement and root resorption? A systematic review of animal studies

2021

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Background The long-term use of contraceptive methods that contain estrogens, progestogens or combinations of the above among women aged 15 to 49 years is extensive. Both estrogens and progestogens affect bone metabolism. Objective To systematically investigate and appraise the quality of the available evidence from animal studies regarding the impact of exogenous administration of female sex hormones on the rate of orthodontic tooth movement and root resorption. Search methods Search without restriction in seven databases (including grey literature) and hand searching were performed until May 2021. Selection criteria We looked for controlled animal studies investigating the effect from exogenous administration of formulations containing female sex hormones on the rate of orthodontic tooth movement and root resorption. Data collection and analysis After study retrieval and selection, relevant data was extracted, and the risk of bias was assessed using the SYRCLE’s Risk of Bias Tool. The quality of available evidence was assessed with the Grades of Recommendation, Assessment, Development, and Evaluation. Results Three studies were identified, all being at unclear risk of bias. Overall, administration of progesterone and the combinations of estradiol with norgestrel and desogestrel were shown to significantly decrease the rate of orthodontic tooth movement when given for longer periods (>3 weeks). Inconsistent information was detected for shorter periods of consumption. Estradiol, with desogestrel use, resulted in less root resorption. The quality of the available evidence was considered to be low. Conclusions Exogenous administration of female sex hormones may decelerate in the long term the rate of tooth movement and decrease orthodontically induced root resorption in animals. Until more information becomes available, an orthodontist should be able to identify a patient consuming such substances and understand the potential clinical implications and adverse effects that may arise. Registration PROSPERO: CRD42017078208; https://clinicaltrials.gov/.

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“…Estradiol stimulates the production of some pro-resorptive cytokines, like interleukins-1, -6, -7 and the tumour necrosis factor [ 52 – 58 ]. Especially serum interleukin-1β and -6, have been shown to play a principal role in bone resorption [ 59 , 60 ] and to fluctuate during the menstrual cycle in humans [ 61 , 62 ].…”

Section: Discussionmentioning

confidence: 99%

Does the rate of orthodontic tooth movement change during the estrus cycle? A systematic review based on animal studies

et al. 2021

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Background As the fluctuation of sex hormone levels in menstruating women results in periodical effects in bone metabolism, understanding the implications for tooth movement could be of benefit to the orthodontist. This type of research presents practical and ethical problems in humans, but animal models could provide useful information. Our objective was to systematically investigate the available evidence on the question whether the rate of orthodontic tooth movement varies between the different stages of the estrus cycle in animals. Methods Unrestricted searches in 7 databases and manual searching of the reference lists in relevant studies were performed up to February 2021 (Medline [PubMed], CENTRAL [Cochrane Library; includes records from Embase, CINAHL, ClinicalTrials.gov, WHO's ICTRP, KoreaMed, Cochrane Review Groups’ Specialized Registers, and records identified by handsearching], Cochrane Database of Systematic Reviews [Cochrane Library], Scopus, Web of Knowledge [including Web of Science Core Collection, KCI Korean Journal Database, Russian Science Citation Index, SciELO Citation Index and Zoological Record], Arab World Research Source [EBSCO] and ProQuest Dissertation and Theses [ProQuest]). Our search focused on prospective controlled animal studies, whose samples included female subjects of any species that were quantitatively comparing the amount of tooth movement in the different stages of the estrus cycle. Following study retrieval and selection, relevant data was extracted, and the risk of bias was assessed using the SYRCLE’s Risk of Bias Tool. Results From the finally assessed records, 3 studies met the inclusion criteria. Two of the studies experimented on Wistar rats, whereas the other on cats. Tooth movement was induced by expansion or coil springs. The rate of orthodontic tooth movement was increased during the stages of the estrus cycle when oestrogen and/or progesterone levels were lower. The risk of bias in the retrieved studies was assessed to be unclear. Conclusion Hormonal changes during the estrus cycle may affect the rate of orthodontic tooth movement. Although these animal experiment results should be approached cautiously regarding their translational potential, it could be useful to consider the possible impact of these physiological changes in the clinical setting until more information becomes available. Registration: PROSPERO (CRD42021158069).

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The interconnected role of chemokines and estrogen in bone metabolism

Cited by 14 publications

References 107 publications

Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment

Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment

Does exogenous female sex hormone administration affect the rate of tooth movement and root resorption? A systematic review of animal studies

Does the rate of orthodontic tooth movement change during the estrus cycle? A systematic review based on animal studies

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