Does exogenous female sex hormone administration affect the rate of tooth movement and root resorption? A systematic review of animal studies

Abstract

Background The long-term use of contraceptive methods that contain estrogens, progestogens or combinations of the above among women aged 15 to 49 years is extensive. Both estrogens and progestogens affect bone metabolism. Objective To systematically investigate and appraise the quality of the available evidence from animal studies regarding the impact of exogenous administration of female sex hormones on the rate of orthodontic tooth movement and root resorption. Search methods Search without restriction in seven databases (including grey literature) and hand searching were performed until May 2021. Selection criteria We looked for controlled animal studies investigating the effect from exogenous administration of formulations containing female sex hormones on the rate of orthodontic tooth movement and root resorption. Data collection and analysis After study retrieval and selection, relevant data was extracted, and the risk of bias was assessed using the SYRCLE’s Risk of Bias Tool. The quality of available evidence was assessed with the Grades of Recommendation, Assessment, Development, and Evaluation. Results Three studies were identified, all being at unclear risk of bias. Overall, administration of progesterone and the combinations of estradiol with norgestrel and desogestrel were shown to significantly decrease the rate of orthodontic tooth movement when given for longer periods (>3 weeks). Inconsistent information was detected for shorter periods of consumption. Estradiol, with desogestrel use, resulted in less root resorption. The quality of the available evidence was considered to be low. Conclusions Exogenous administration of female sex hormones may decelerate in the long term the rate of tooth movement and decrease orthodontically induced root resorption in animals. Until more information becomes available, an orthodontist should be able to identify a patient consuming such substances and understand the potential clinical implications and adverse effects that may arise. Registration PROSPERO: CRD42017078208; https://clinicaltrials.gov/.

Effects of clear aligners on the vertical position of the molar teeth and the vertical and sagittal relationships of the face: a preliminary retrospective before-after clinical trial

“…Dental movements are expected to be greater in younger patients and in women due to their lower bone densities [ 26 ]. Nevertheless, in our study no significant relationship between age and dental or skeletal changes was observed.…”

Immune System Acts on Orthodontic Tooth Movement: Cellular and Molecular Mechanisms

“…Cementoblastic activities and the amount of new cementum formation are lower in ovariectomized rats, thus affecting the activation of extracellular signal-regulated kinase-1/2 pathway. Given the similarity between cementoblasts and osteoblasts, it is unsurprising that some scholars manage to reduce EARR by locally injecting a variety of bone forming associated hormones in animals (e.g., estrogen, thyroxine, prostaglandin E2, and parathyroid hormone) [129][130][131][132]. However, the underlying mechanisms and the effects of local application of hormones BioMed Research International on immune status remain unclear, and it is necessary to conduct further investigations.…”