The interaction of S,N-coordinated dimethyltin(IV) derivatives with deoxyribonucleic acid: structure and dynamics by119Sn Mössbauer spectroscopy

Barbieri, Renato; Huber, F.; Silvestri, Arturo; Ruisi, Gìuseppe; Rossi, Mario; Barone, Giampaolo; Paulsen, Adriana Barbieri

doi:10.1002/(sici)1099-0739(199908)13:8<595::aid-aoc894>3.0.co;2-0

Cited by 15 publications

(7 citation statements)

References 34 publications

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“…The UV–visible spectral technique is the most frequently used method to study the interaction of transition metal complexes with DNA, since these complexes often have abundant spectroscopic properties . Normally, DNA binding ability of the complexes is assessed by measuring the effects on their UV spectra in the presence of DNA .…”

Section: Resultsmentioning

confidence: 99%

Nitrile‐functionalized Hg(II)‐ and Ag(I)‐N‐heterocyclic carbene complexes: synthesis, crystal structures, nuclease and DNA binding activities

Haque

Budagumpi

Choo

et al. 2012

Applied Organom Chemis

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Various nitrile‐functionalized benzimidazol‐2‐ylidene carbene complexes of Hg(II) and Ag(I) were synthesized by the interaction of 1‐benzyl/1‐butyl‐3‐(cyano‐benzyl)‐3 H‐benzimidazol‐1‐ium mono/dihexafluorophosphate with Hg(OAc)2/Ag2O in acetonitrile. Two of the benzimidazolium salts were structurally characterized by single crystal X‐ray diffraction technique. Structures of reported compounds were characterized by 1 H, 13C NMR, FT‐IR, UV–visible spectroscopic techniques, and molar conductivity and elemental analyses. For bis‐benzimidazolium salt, dinuclear Hg(II)– and Ag(I)–carbene complexes were obtained. Nuclease activity and binding interactions of the synthesized benzimidazolium salts and their Ag(I)–carbene complexes with DNA were studied using agarose gel electrophoresis and, absorption spectroscopy and viscosity measurements, respectively. Ag(I)–carbene complexes showed higher DNA binding activity compared to their respective benzimidazolium salts. However, a benzimidazolium salt and two of the Ag(I) complexes showed remarkably higher nuclease activity both, in the presence and absence of an oxidizing agent. Copyright © 2012 John Wiley & Sons, Ltd.

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Section: Resultsmentioning

confidence: 99%

Nitrile‐functionalized Hg(II)‐ and Ag(I)‐N‐heterocyclic carbene complexes: synthesis, crystal structures, nuclease and DNA binding activities

Haque

Budagumpi

Choo

et al. 2012

Applied Organom Chemis

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“…Sn is a potent DNA-DNA and DNA-protein cross-linking agent because it binds to two or more ligand groups and because it can extend its linking range via Sn-Sn or Sn-O bridges (Veith and Recktenwald 1982). Different organic Sn(IV) complexes form interesting complexes with DNA (Barbieri et al 1999;Casini et al 2001;Silvestri et al 2000). Sn(IV), without cleaving the dsDNA, directly coordinates to oxygen atoms of the negatively-charged DNA phosphate groups (Li et al 1996) via electrostatic interactions (Arjmand and Jamsheera 2011).…”

Section: Tinmentioning

confidence: 99%

A review of heavy metal cation binding to deoxyribonucleic acids for the creation of chemical sensors

Kanellis

Remedios

2018

Biophys Rev

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Various human activities lead to the pollution of ground, drinking, and wastewater with toxic metals. It is well known that metal ions preferentially bind to DNA phosphate backbones or DNA nucleobases, or both. Foreman et al. (Environ Toxicol Chem 30(8):1810-1818, 2011) reported the use of a DNA-dye based assay suitable for use as a toxicity test for potable environmental water. They compared the results of this test with the responses of live-organism bioassays. The DNA-based demonstrated that the loss of SYBR Green I fluorescence dye bound to calf thymus DNA was proportional to the toxicity of the water sample. However, this report raised questions about the mechanism that formed the basis of this quasi-quantitatively test. In this review, we identify the unique and preferred DNA-binding sites of individual metals. We show how highly sensitive and selective DNA-based sensors can be designed that contain multiple binding sites for 21 heavy metal cations that bind to DNA and change its structure, consistent with the release of the DNA-bound dye.

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“…The spectrum of the biomedicinal aspects of organotin compounds has been expanded as they have found their place among a class of potential biologically active compounds [1][2][3][4] exhibiting antimicrobial activity against different kinds of microbial strains [5][6][7][8][9][10][11][12][13][14]. They also show anti-inflammatory and cardiovascular activity [15], trypanosomal activity [16,17] along with anti-herpes [18] and anti-tubercular activity [19].…”

Section: Introductionmentioning

confidence: 99%

Studies on Antimicrobial and Antitumor Efficacy of Some New Diorganotin (Iv) Dicarboxylates

Ic¹,

Shukla²,

VK³

et al. 2011

Int J of Chem Res

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In this manuscript a series of new diorganotin (IV) dicarboxylates were screened out first time for their bio medicinal activity, like antimicrobial and in-vitro antitumor activity against different pathogenic bacterial and fungal strains along with human breast and mammary cancer cell line. It was found that the compounds show remarkable antitumor efficacy and moderate antimicrobial activity against pathogenic microbial strains.

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The interaction of S,N-coordinated dimethyltin(IV) derivatives with deoxyribonucleic acid: structure and dynamics by119Sn Mössbauer spectroscopy

Cited by 15 publications

References 34 publications

Nitrile‐functionalized Hg(II)‐ and Ag(I)‐N‐heterocyclic carbene complexes: synthesis, crystal structures, nuclease and DNA binding activities

Nitrile‐functionalized Hg(II)‐ and Ag(I)‐N‐heterocyclic carbene complexes: synthesis, crystal structures, nuclease and DNA binding activities

A review of heavy metal cation binding to deoxyribonucleic acids for the creation of chemical sensors

Studies on Antimicrobial and Antitumor Efficacy of Some New Diorganotin (Iv) Dicarboxylates

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