The interaction of antitumor-active anthraquinones with biologically important redox couples: I. Spectrophotometric investigation of the interaction of carminic acid and mitoxantrone with the iron(II, III) and copper(I, II) redox couples

Tütem, Esma; Apak, Reşat; Sözgen, Kevser

doi:10.1016/0162-0134(95)00023-2

Cited by 18 publications

(9 citation statements)

References 34 publications

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“…NBT acts as a superoxide radical reagent by producing the deep-blue-colored diformazan (Tiitem et al 1996). NBT substrate was incorporated into polyacrylamide gels by adding the superoxide anioninducing agent riboflavin.…”

Section: Resultsmentioning

confidence: 99%

“…The redox-active transition metals capable of forming the physiological redox couples, such as Fe(II) and Fe(III), may be involved in free radical reactions either in macromolecule (protein)-bound or free ionic forms (Tiitem et al 1996). We performed experiments to test the antioxidant ability of polypeptide-Fe, and hopefully the results of the present study may provide some useful information relevant to an additional contribution of hemoglobin besides its fortification role in the treatment of iron-deficiency anemia (IDA).…”

Section: Introductionmentioning

confidence: 99%

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A new nutrient polypeptide-Fe and its antioxidant ability

Liu

Wang

et al. 2009

International Journal of Food Sciences and Nutrition

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Polypeptide-Fe is the hemoglobin that is purified highly from animal blood. It is an active material obtained by connecting heme with a different-length peptide section after physical and chemical processing. Polypeptide-Fe is non-toxic to the human body, does not have the side effects, and namely has iron enhancement function. Nitroblue tetrazolium staining showed that it retained the superoxide radical scavenging activity of hemoglobin. Polypeptide-Fe achieves the elimination of free radical by degradations of the polypeptide connected to iron. Oxidative stress has been considered to play an important role in the pathogenesis of iron-deficiency anemia. The primary free radicals in most of biological system are the superoxide anion, hydrogen peroxide, and the hydroxyl free radical. We performed experiments to detect the clearance ability on these three free radicals and maleic dialdehyde by polypeptide-Fe. Results of the present study showed that polypeptide-Fe had strong antioxidant ability and it may provide some useful information relevant to an additional contribution to the treatment of iron-deficiency anemia in future.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A new nutrient polypeptide-Fe and its antioxidant ability

Liu

Wang

et al. 2009

International Journal of Food Sciences and Nutrition

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“…Sadik, Sies, and Schewe (2003) reported that polyphenols containing a catechol group behave as good LOX inhibitors due to their ability as a transition metal chelant or an iron ion reducer. Tütem, Apak, and Sözgen (1996) reported about CA complexes with iron and copper, and those formed with the higher metal valences are more stable than the lower valence ones. Since Fe (III) is the corresponding metal valence of the active form of LOX, this would be related to enzyme inhibition by CA.…”

Section: Discussionmentioning

confidence: 99%

Free radical scavenging capacity and antioxidant activity of cochineal (Dactylopius coccus C.) extracts

2010

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“…It is well known that anthraquinones can bind DNA by inserting and stacking between the base pairs of DNA double helices (Silverman, 2004). There are several proposed mechanisms regarding the drug's anticancer activity: one involves the drug's capability to intercalate DNA (Piedade et al, 2002;Hsiao et al, 2008) and to inhibit DNA topoisomerase II (Capranico et al, 1994;Perchellet et al, 2000;Teich et al, 2004;Dal Ben et al, 2007) and the other involves the drug's ability to produce free radicals and consequently to cleave DNA (Fisher et al, 1992;Tütem et al, 1996). In a recent study, we showed that derivatives of 2-(1-hydroxyalkyl)-1,4-dihydroxyl-9,10-anthraquinone displayed antitumor activity (Jin et al, 1998a(Jin et al, , 1998bTam et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and antiproliferative activity of 1,4-bis(dimethylamino)-9,10-anthraquinone derivatives against P388 mouse leukemic tumor cells

Jin

2011

Arch. Pharm. Res.

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A series of 2-substituted-1,4-bis(dimethylamino)-9,10-anthraquinone derivatives were synthesized and their in vitro antiproliferative activities against p388 mouse leukemic tumor cells were evaluated. In addition, the effect of substituents on the phenyl ring was investigated. Among the derivatives tested, seven showed a high antiproliferative effect and three showed a moderate effect. In addition, introduction of a series of substituted phenyl groups into 1,4-bis(dimethylamino)-9,10-anthraquinone at 2-position were shown to enhance its antiproliferative activity. The antiproliferative activity also increased upon substitution of the benzene ring by an electron donating group such as an amine or methoxyl group.

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The interaction of antitumor-active anthraquinones with biologically important redox couples: I. Spectrophotometric investigation of the interaction of carminic acid and mitoxantrone with the iron(II, III) and copper(I, II) redox couples

Cited by 18 publications

References 34 publications

A new nutrient polypeptide-Fe and its antioxidant ability

A new nutrient polypeptide-Fe and its antioxidant ability

Free radical scavenging capacity and antioxidant activity of cochineal (Dactylopius coccus C.) extracts

Synthesis and antiproliferative activity of 1,4-bis(dimethylamino)-9,10-anthraquinone derivatives against P388 mouse leukemic tumor cells

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