“…The scientific problem of identifying non-animal test methods in this field was addressed (Hareng et al, 2005). The project was based on a battery of in vitro methods that covered different steps of the reproductive cycle (Fig.…”
Section: Fig 13: Schematic Explanation Of Quantitative In Vitro -In mentioning
“…The scientific problem of identifying non-animal test methods in this field was addressed (Hareng et al, 2005). The project was based on a battery of in vitro methods that covered different steps of the reproductive cycle (Fig.…”
Section: Fig 13: Schematic Explanation Of Quantitative In Vitro -In mentioning
“…the systematic construction of components for an ItS represents a key opportunity to advance the overall ItS approach. A very promising way of constructing a testing strategy is breaking the (patho-)physiology down to crucial elements, e.g., the different elements of the reproductive cycle (as was done for the ReProtect project) (Hareng et al, 2005) or the key processes of neurodevelopment in the series of DNt workshops. However, this still leaves open the question of how to integrate all these tests.…”
Section: Optimization Of Existing Testsmentioning
confidence: 99%
“…A series of activities by ECVAM, including several workshops, have tackled this challenge and will be condensed here. The Integrated Project ReProTect (Hareng et al, 2005) was one of its offspring, pioneering several alternative approaches. Reproductive toxicity aims to assess possible hazard to the reproductive cycle, with certain emphasis on embryotoxicity.…”
“…In vitro approaches are furthered by the eU ReProtect project (Hareng et al, 2005), but a replacement strategy is not foreseeable. Currently, the most important approach is the ongoing validation of replacing the two-generation test by an extended It is assumed that long term toxicity on fish is required for 5% of substances produced in quantities <100t/y and 10% of substances produced in quantities ≥100t/y.…”
Section: Short-term and Long-term Fish Acute Toxicitymentioning
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