The inhibition of heme oxigenase-1 (HO-1) abolishes the mitochondrial protection induced by sesamol in LPS-treated RAW 264.7 cells

Duarte, Adriane Ribeiro; Chenet, Aline Lukasievicz; Almeida, Fhelipe Jolner Souza de; Andrade, Claudia Marlise Balbinotti; Oliveira, Marcos Roberto de

doi:10.1016/j.cbi.2018.09.012

Cited by 11 publications

(10 citation statements)

References 63 publications

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“…Sesamin is another prominent compound reported in SO that possesses significant protective effects against oxidative stress in animal model including through ameliorate SOD, GPx, reduction of malondialdehyde and elevated different liver marker, TBARS, and lipid peroxidation as well as reduction of superoxide production (Ahmad et al, ; Chen, Ying, Chen, Zhang, & Zhang, ; Hou, Chang, & Jeng, ; Hsieh et al, ; Jeng & Hou, ; Jnaneshwari et al, ; Nakai et al, ; Tian & Guo, ; Zhang et al, ). In vitro studies of sesamin especially in neuronal cell line (PC12), it showed reduction of reactive oxygen species (ROS) generation especially NO production (Cao et al, ; Duarte, Chenet, de Almeida, Andrade, & de Oliveira, ; Lee et al, ; Yashaswini, Rao, & Singh, ). However, Hou et al () reported that 10‐μM sesamin derivative, 3‐bis (3‐methoxybenzyl) butane‐1, 4‐diol, inhibits lactate dehydrogenase, lipid peroxidation, and apoptosis as well as increases ACh release and also prevents cell damage, scavenges ROS, and attenuates the elevation of intracellular free Ca 2+ ion on Aβ‐stressed PC12 cells (Hou et al, ).…”

Section: Resultsmentioning

confidence: 99%

A systematic review on antioxidant and antiinflammatory activity of Sesame (Sesamum indicum L.) oil and further confirmation of antiinflammatory activity by chemical profiling and molecular docking

Afroz

Zihad

Uddin

et al. 2019

Phytotherapy Research

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Traditionally, sesame oil (SO) has been used as a popular food and medicine. The review aims to summarize the antioxidant and antiinflammatory effects of SO and its identified compounds as well as further fatty acid profiling and molecular docking study to correlate the interaction of its identified constituents with cyclooxygenase-2 (COX-2). For this, a literature study was made using Google Scholar, Pubmed, and SciFinder databases. Literature study demonstrated that SO has potential antioxidant and antiinflammatory effects in various test systems, including humans, animals, and cultured cells through various pathways such as inhibition of COX, nonenzymatic defense mechanism, inhibition of proinflammatory cytokines, NF-kB or mitogenactivated protein kinase signaling, and prostaglandin synthesis pathway. Fatty acid analysis of SO using gas chromatography identified known nine fatty acids. In silico study revealed that sesamin, sesaminol, sesamolin, stigmasterol, Δ5-avenasterol, and Δ7-avenasterol (−9.6 to −10.7 kcal/mol) were the most efficient ligand for interaction and binding with COX-2. The known fatty acid also showed binding efficiency with COX-2 to some extent (−6.0 to −8.4 kcal/mol). In summary, it is evident that SO may be one of promising traditional medicines that we could use in the prevention and management of diseases associated with oxidative stress and inflammation.

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Section: Resultsmentioning

confidence: 99%

A systematic review on antioxidant and antiinflammatory activity of Sesame (Sesamum indicum L.) oil and further confirmation of antiinflammatory activity by chemical profiling and molecular docking

Afroz

Zihad

Uddin

et al. 2019

Phytotherapy Research

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show abstract

“…Studies have shown that sesamol could induce apoptosis in cancer cells and inhibit the effects of proliferation and autophagy in lung cancer and colon cancer [11]. We and other research groups also discovered that sesamol could inhibit the secretion of inflammatory cytokines and reduce oxidative damage caused by inflammatory macrophages [12,23]. Other studies found that sesamol could ameliorate the effects of oxidative stress and inflammation in focal cerebral ischemia/reperfusion injury in the rat brain [24].…”

Section: Discussionmentioning

confidence: 96%

“…Next, mice inhaled 2% OVA administered with an ultrasonic nebulizer for 30 min to induce asthma symptoms (DeVilbiss Pulmo-Aide 5650D, United States) on days 14, 17, 20, 23, and 27. Then, for 2 weeks (days [14][15][16][17][18][19][20][21][22][23][24][25][26][27], in addition to their regular diet, each mouse group received a daily dose of saline (N and OVA groups), sesamol (S10 and S30 groups), or prednisolone (P group). On day 28, we calculated the AHR in all mice; then, on day 29, we sacrificed mice to investigate the asthma pathology, immune regulation, inflammation, and oxidative stress.…”

Section: Establishment Of An Asthma Model and Sesamol Administrationmentioning

confidence: 99%

Sesamol Alleviates Airway Hyperresponsiveness and Oxidative Stress in Asthmatic Mice

Liou

Chen

et al. 2020

Antioxidants

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Sesamol, isolated from sesame seeds (Sesamum indicum), was previously shown to have antioxidative, anti-inflammatory, and anti-tumor effects. Sesamol also inhibited lipopolysaccharide (LPS)-induced pulmonary inflammatory response in rats. However, it remains unclear how sesamol regulates airway inflammation and oxidative stress in asthmatic mice. This study aimed to investigate the efficacy of sesamol on oxidative stress and airway inflammation in asthmatic mice and tracheal epithelial cells. BALB/c mice were sensitized with ovalbumin, and received oral sesamol on days 14 to 27. Furthermore, BEAS-2B human bronchial epithelial cells were treated with sesamol to investigate inflammatory cytokine levels and oxidative responses in vitro. Our results demonstrated that oral sesamol administration significantly suppressed eosinophil infiltration in the lung, airway hyperresponsiveness, and T helper 2 cell-associated (Th2) cytokine expressions in bronchoalveolar lavage fluid and the lungs. Sesamol also significantly increased glutathione expression and reduced malondialdehyde levels in the lungs of asthmatic mice. We also found that sesamol significantly reduced proinflammatory cytokine levels and eotaxin in inflammatory BEAS-2B cells. Moreover, sesamol alleviated reactive oxygen species formation, and suppressed intercellular cell adhesion molecule-1 (ICAM-1) expression, which reduced monocyte cell adherence. We demonstrated that sesamol showed potential as a therapeutic agent for improving asthma.

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“…SML has been previously tested on different cell lines as an antioxidant to protect them against the damaging effect of cancer therapy. [36]. Sesamol could reduce the oxidative damage and the toxicity to H9c2 cardiomyoblasts caused by doxorubicin [37].…”

Section: Discussionmentioning

confidence: 99%

Sesamol Loaded Albumin Nanoparticles: A Boosted Protective Property in Animal Models of Oxidative Stress

et al. 2022

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The current study evaluated the ability of sesamol-loaded albumin nanoparticles to impart protection against oxidative stress induced by anthracyclines in comparison to the free drug. Albumin nanoparticles were prepared via the desolvation technique and then freeze-dried with the cryoprotectant, trehalose. Albumin concentration, pH, and type of desolvating agent were assessed as determining factors for successful albumin nanoparticle fabrication. The optimal nanoparticles were spherical in shape, and they had an average particle diameter of 127.24 ± 2.12 nm with a sesamol payload of 96.89 ± 2.4 μg/mg. The drug cellular protection was tested on rat hepatocytes pretreated with 1 µM doxorubicin, which showed a 1.2-fold higher protective activity than the free sesamol. In a pharmacokinetic study, the loading of a drug onto nanoparticles resulted in a longer half-life and mean residence time, as compared to the free drug. Furthermore, in vivo efficacy and biochemical assessment of lipid peroxidation, cardiac biomarkers, and liver enzymes were significantly ameliorated after administration of the sesamol-loaded albumin nanoparticles. The biochemical assessments were also corroborated with the histopathological examination data. Sesamol-loaded albumin nanoparticles, prepared under controlled conditions, may provide an enhanced protective effect against off-target doxorubicin toxicity.

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The inhibition of heme oxigenase-1 (HO-1) abolishes the mitochondrial protection induced by sesamol in LPS-treated RAW 264.7 cells

Cited by 11 publications

References 63 publications

A systematic review on antioxidant and antiinflammatory activity of Sesame (Sesamum indicum L.) oil and further confirmation of antiinflammatory activity by chemical profiling and molecular docking

A systematic review on antioxidant and antiinflammatory activity of Sesame (Sesamum indicum L.) oil and further confirmation of antiinflammatory activity by chemical profiling and molecular docking

Sesamol Alleviates Airway Hyperresponsiveness and Oxidative Stress in Asthmatic Mice

Sesamol Loaded Albumin Nanoparticles: A Boosted Protective Property in Animal Models of Oxidative Stress

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The inhibition of heme oxigenase-1 (HO-1) abolishes the mitochondrial protection induced by sesamol in LPS-treated RAW 264.7 cells

Cited by 11 publications

References 63 publications

A systematic review on antioxidant and antiinflammatory activity of Sesame (Sesamum indicum L.) oil and further confirmation of antiinflammatory activity by chemical profiling and molecular docking

A systematic review on antioxidant and antiinflammatory activity of Sesame (Sesamum indicum L.) oil and further confirmation of antiinflammatory activity by chemical profiling and molecular docking

Sesamol Alleviates Airway Hyperresponsiveness and Oxidative Stress in Asthmatic Mice

Sesamol Loaded Albumin Nanoparticles: A Boosted Protective Property in Animal Models of Oxidative Stress

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The inhibition of heme oxigenase-1 (HO-1) abolishes the mitochondrial protection induced by sesamol in LPS-treated RAW 264.7 cells