Sesamol Alleviates Airway Hyperresponsiveness and Oxidative Stress in Asthmatic Mice

Liou, Chian-Jiun; Chen, Ya Ling; Yu, Ming; Yeh, Kuo Wei; Shen, Sheng‐Feng; Huang, Wen‐Chung

doi:10.3390/antiox9040295

Cited by 29 publications

(19 citation statements)

References 55 publications

(98 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Natural antioxidant compounds are important in modulating diseases associated with environmental pollutants causing oxidative stress by scavenging free radicals (Majdalawieh & Mansour, 2019). In a study, sesamol alleviates airway hyperresponsiveness and oxidative stress in asthmatic mice (Liou et al., 2020). Ren et al.…”

Section: Discussionmentioning

confidence: 99%

Lead nitrate and cadmium chloride induced hepatotoxicity and nephrotoxicity: Protective effects of sesamol on biochemical indices and pathological changes

et al. 2021

View full text Add to dashboard Cite

Lead nitrate (LN) and cadmium chloride (CdCl2), regarded as environmental contaminants, are toxic heavy metals. Sesamol is a dietary phytochemical found in sesame oil. We aimed to analyze the hepatotoxic and nephrotoxic effects of LN and CdCl2 and to evaluate the possible protective effect of sesamol. LN (90 mg/kg bw per day), CdCl2 (3 mg/kg bw per day), and sesamol (50 mg/kg bw per day) were given to rats via gavage for 28 days. Total protein, albumin, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, total cholesterol, urea, uric acid, creatinine, superoxide dismutase, catalase, glutathione peroxidase, glutathione‐S‐transferase, malondialdehyde, acetylcholinesterase, and histopathological changes were investigated in liver and kidney tissues. Lead and cadmium were found to result in decreases in the antioxidant enzymes and acetylcholinesterase activities, increases in malondialdehyde levels, and changes in serum biochemical parameters and various pathological findings. An improvement in all these parameters was observed in the sesamol‐treated groups. Practical applications Heavy metals are used in many areas of the industry all over the world. Heavy metals which include lead nitrate and cadmium chloride cause cell damage by oxidative stress. Some of the examining parameters for oxidative stress are SOD, GST, MDA, GPx, and CAT. However, some chemicals such as sesamol are well‐liked and widely used as antioxidants against xenobiotic toxicity. We also indicate that sesamol has been shown to protective effect against heavy metals caused cell damage.

show abstract

Section: Discussionmentioning

confidence: 99%

Lead nitrate and cadmium chloride induced hepatotoxicity and nephrotoxicity: Protective effects of sesamol on biochemical indices and pathological changes

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Many researchers have reported the biomedical applications of herbal medicines [ 346 , 347 , 348 , 349 , 350 , 351 , 352 , 353 , 354 , 355 , 356 , 357 , 358 , 359 , 360 , 361 , 362 , 363 , 364 , 365 ]. Antibiotics and other chemical antimicrobial agents including metal oxide and metal nanoparticles can inhibit bacteria growth but also lead to ROS generation and other side effects.…”

Section: Conclusion and The Future Outlookmentioning

confidence: 99%

Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials

et al. 2020

View full text Add to dashboard Cite

Recently, increasing public concern about hygiene has been driving many studies to investigate antimicrobial and antiviral agents. However, the use of any antimicrobial agents must be limited due to their possible toxic or harmful effects. In recent years, due to previous antibiotics’ lesser side effects, the use of herbal materials instead of synthetic or chemical drugs is increasing. Herbal materials are found in medicines. Herbs can be used in the form of plant extracts or as their active components. Furthermore, most of the world’s populations used herbal materials due to their strong antimicrobial properties and primary healthcare benefits. For example, herbs are an excellent material to replace nanosilver as an antibiotic and antiviral agent. The use of nanosilver involves an ROS-mediated mechanism that might lead to oxidative stress-related cancer, cytotoxicity, and heart diseases. Oxidative stress further leads to increased ROS production and also delays the cellular processes involved in wound healing. Therefore, existing antibiotic drugs can be replaced with biomaterials such as herbal medicine with high antimicrobial, antiviral, and antioxidant activity. This review paper highlights the antibacterial, antiviral, and radical scavenger (antioxidant) properties of herbal materials. Antimicrobial activity, radical scavenger ability, the potential for antimicrobial, antiviral, and anticancer agents, and efficacy in eliminating bacteria and viruses and scavenging free radicals in herbal materials are discussed in this review. The presented herbal antimicrobial agents in this review include clove, portulaca, tribulus, eryngium, cinnamon, turmeric, ginger, thyme, pennyroyal, mint, fennel, chamomile, burdock, eucalyptus, primrose, lemon balm, mallow, and garlic, which are all summarized.

show abstract

“…A study reported that it decreased the eosinophil infiltration in lungs, Th2 cytokines, and MDA levels in asthmatic BALB/c mice, and BEAS-2B cells. Further, it reduced the levels of eotaxin, ROS, and ICAM-1 (suppressing adherence of monocytic cell), which might attenuate inflammations in the lungs [ 324 ].…”

Section: Anti-inflammatory Role Of Spicesmentioning

confidence: 99%

COVID-19, cytokines, inflammation, and spices: How are they related?

et al. 2021

View full text Add to dashboard Cite

Background Cytokine storm is the exaggerated immune response often observed in viral infections. It is also intimately linked with the progression of COVID-19 disease as well as associated complications and mortality. Therefore, targeting the cytokine storm might help in reducing COVID-19-associated health complications. The number of COVID-associated deaths (as of January 15, 2021; https://www.worldometers.info/coronavirus/ ) in the USA is high (1199/million) as compared to countries like India is low (110/million). Although the reason behind this is not clear, spices may have some role in explaining this difference. Spices and herbs are used in different traditional medicines, especially in countries such as India to treat various chronic diseases due to their potent antioxidant and anti-inflammatory properties. Aim To evaluate the literature available on the anti-inflammatory properties of some spices which might prove beneficial in the prevention and treatment of COVID-19 associated cytokine storm. Method A detailed literature search has been conducted on PubMed for collecting information pertaining to the COVID-19; the history, origin, key structural features, and mechanism of infection of SARS-CoV-2; the repurposed drugs in use for the management of COVID-19 and the anti-inflammatory role of spices to combat COVID-19 associated cytokine storm. Key findings The literature search resulted in numerous in vitro , in vivo and clinical trials that have reported the potency of spices to exert anti-inflammatory effects by regulating crucial molecular targets for inflammation. Significance As spices are derived from Mother Nature and are inexpensive, they are relatively safer to consume. Therefore, their anti-inflammatory property can be exploited to combat the cytokine storm in COVID-19 patients. This review thus focuses on the current knowledge on the role of spices for the treatment of COVID-19 through suppression of inflammation-linked cytokine storm.

show abstract

Sesamol Alleviates Airway Hyperresponsiveness and Oxidative Stress in Asthmatic Mice

Cited by 29 publications

References 55 publications

Lead nitrate and cadmium chloride induced hepatotoxicity and nephrotoxicity: Protective effects of sesamol on biochemical indices and pathological changes

Lead nitrate and cadmium chloride induced hepatotoxicity and nephrotoxicity: Protective effects of sesamol on biochemical indices and pathological changes

Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials

COVID-19, cytokines, inflammation, and spices: How are they related?

Contact Info

Product

Resources

About