The influence of ultrasound-induced microbubble cavitation on the viability, migration and cell cycle distribution of melanoma cells

Yang, Dongxin; Zhang, Qi; Zhang, Zhizheng; Yuan, Ziyan; Xu, Guangyao; Wu, Jun; Zhang, Mingshun; Guo, Xiaojun; Tu, Juan; Zhang, Dong

doi:10.1016/j.apacoust.2021.108056

Cited by 7 publications

(6 citation statements)

References 48 publications

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“…The experimental apparatus for PCD experiments is shown in Fig. 1 a, while the experimental details can be found in the previous work [3] . The experimental apparatus for in vitro thrombolysis experiments is shown in Fig.…”

Section: Methodsmentioning

confidence: 99%

“…In the field of biomedical research, ultrasonic cavitation has demonstrated its significance in various applications of high-intensity focused ultrasound (HIFU) therapy. These include tumor treatment [1] , [2] , [3] , lithotripsy [4] , histotripsy [5] , [6] , thrombolysis [7] , [8] , [9] , blood–brain barrier disruption [10] , [11] and drug delivery [12] , [13] . The dynamics of cavitation in response to ultrasound excitation can be classified into two types, namely stable cavitation (SC) and inertial cavitation (IC) [14] .…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, gaining insight into the mechanism of cavitation and the optimization of treatment process is essential to improve the efficacy of thrombolytic treatment. Passive cavitation detection (PCD) [3] , [14] , [21] , [22] , [23] has emerged as a useful monitoring method for ultrasound treatment, offering superior detection sensitivity compared with pulse-echo detection [21] . The application of PCD allows for the identification of cavitation occurrence and can help understanding of the mechanism of cavitation generated at different acoustic and nuclei’s parameters, enabling the optimization of therapeutic effects.…”

Section: Introductionmentioning

confidence: 99%

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Enhanced thrombolytic effect induced by acoustic cavitation generated from nitrogen-doped annealed nanodiamond particles

Zhang,

Xue,

Zhang

et al. 2023

Ultrasonics Sonochemistry

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Enhanced thrombolytic effect induced by acoustic cavitation generated from nitrogen-doped annealed nanodiamond particles

Zhang,

Xue,

Zhang

et al. 2023

Ultrasonics Sonochemistry

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“…Another study has shown that, for

-phase cells that are undergoing DNA synthesis, they have exhibited a higher level of model drug uptake in direct response to sonoporation, while their actin cytoskeleton have disassembled at a faster rate immediately after sonoporation [ 96 ]. Such observations may be mechanistically linked to different levels of microstreaming-induced shear stress exerted on cells in various cell-cycle phases whose membrane elasticity is known to differ [ 96 , 191 ].…”

Section: Factors Affecting Sonoporation Dynamics and Bioeffectsmentioning

confidence: 99%

Ultrasound-Mediated Drug Delivery: Sonoporation Mechanisms, Biophysics, and Critical Factors

2022

BME Front

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Sonoporation, or the use of ultrasound in the presence of cavitation nuclei to induce plasma membrane perforation, is well considered as an emerging physical approach to facilitate the delivery of drugs and genes to living cells. Nevertheless, this emerging drug delivery paradigm has not yet reached widespread clinical use, because the efficiency of sonoporation is often deemed to be mediocre due to the lack of detailed understanding of the pertinent scientific mechanisms. Here, we summarize the current observational evidence available on the notion of sonoporation, and we discuss the prevailing understanding of the physical and biological processes related to sonoporation. To facilitate systematic understanding, we also present how the extent of sonoporation is dependent on a multitude of factors related to acoustic excitation parameters (ultrasound frequency, pressure, cavitation dose, exposure time), microbubble parameters (size, concentration, bubble-to-cell distance, shell composition), and cellular properties (cell type, cell cycle, biochemical contents). By adopting a science-backed approach to the realization of sonoporation, ultrasound-mediated drug delivery can be more controllably achieved to viably enhance drug uptake into living cells with high sonoporation efficiency. This drug delivery approach, when coupled with concurrent advances in ultrasound imaging, has potential to become an effective therapeutic paradigm.

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“…Inertial cavitation occurs when the oscillation amplitude of a bubble is sufficiently high and exceeds a certain threshold; then, the bubble expands and shrinks sharply or even collapses. This reaction can be used in biological applications such as cell sorting and cell lysis [ 59 , 60 ]. Most oscillating bubbles in microfluids are stable, non-inertial cavitated bubbles.…”

Section: Generation and Control Of Bubblesmentioning

confidence: 99%

Review of Bubble Applications in Microrobotics: Propulsion, Manipulation, and Assembly

2022

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In recent years, microbubbles have been widely used in the field of microrobots due to their unique properties. Microbubbles can be easily produced and used as power sources or tools of microrobots, and the bubbles can even serve as microrobots themselves. As a power source, bubbles can propel microrobots to swim in liquid under low-Reynolds-number conditions. As a manipulation tool, microbubbles can act as the micromanipulators of microrobots, allowing them to operate upon particles, cells, and organisms. As a microrobot, microbubbles can operate and assemble complex microparts in two- or three-dimensional spaces. This review provides a comprehensive overview of bubble applications in microrobotics including propulsion, micromanipulation, and microassembly. First, we introduce the diverse bubble generation and control methods. Then, we review and discuss how bubbles can play a role in microrobotics via three functions: propulsion, manipulation, and assembly. Finally, by highlighting the advantages and current challenges of this progress, we discuss the prospects of microbubbles in microrobotics.

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The influence of ultrasound-induced microbubble cavitation on the viability, migration and cell cycle distribution of melanoma cells

Cited by 7 publications

References 48 publications

Enhanced thrombolytic effect induced by acoustic cavitation generated from nitrogen-doped annealed nanodiamond particles

Enhanced thrombolytic effect induced by acoustic cavitation generated from nitrogen-doped annealed nanodiamond particles

Ultrasound-Mediated Drug Delivery: Sonoporation Mechanisms, Biophysics, and Critical Factors

Review of Bubble Applications in Microrobotics: Propulsion, Manipulation, and Assembly

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