Enhanced thrombolytic effect induced by acoustic cavitation generated from nitrogen-doped annealed nanodiamond particles

Zhang, Qi; Xue, Honghui; Zhang, Haijun; Chen, Yuqi; Liu, Zijun; Fan, Zheng; Guo, Xiasheng; Wu, Xiaoge; Zhang, Dong; Tu, Juan

doi:10.1016/j.ultsonch.2023.106563

Cited by 8 publications

(1 citation statement)

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“…Under certain ultrasound intensities, ultrasound microbubbles undergo transient bursting due to acoustic response, creating a “cavitation effect” that temporarily enhances cell membrane permeability, thereby assisting in gene delivery/release. 123 By creating an ultrasound environment at the tumor site, ultrasound-responsive NDRS can effectively deliver/release the target gene to the target site, and overcome “off-target” effects. Du et al designed mesoporous silica nanobubbles (M-MSN@MBs) for ultrasound-mediated gene delivery/release.…”

Section: Application Of Stimulus-responsive Ndrsmentioning

confidence: 99%

Stimulus-Responsive Nanodelivery and Release Systems for Cancer Gene Therapy: Efficacy Improvement Strategies

Zeng,

Zhang,

Liu

et al. 2024

IJN

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Introduction of exogenous genes into target cells to overcome various tumor diseases caused by genetic defects or abnormalities and gene therapy, a new treatment method, provides a promising strategy for tumor treatment. Over the past decade, gene therapy has made exciting progress; however, it still faces the challenge of low nucleic acid delivery and release efficiencies. The emergence of nonviral vectors, primarily nanodelivery and release systems (NDRS), has resulted in a historic breakthrough in the application of gene therapy. NDRS, especially stimulus-responsive NDRS that can respond in a timely manner to changes in the internal and external microenvironment (eg, low pH, high concentration of glutathione/reactive oxygen species, overexpressed enzymes, temperature, light, ultrasound, and magnetic field), has shown excellent loading and release advantages in the precision and efficiency of tumor gene therapy and has been widely applied. The only disadvantage is that poor transfection efficiency limits the in-depth application of gene therapy in clinical practice, owing to the presence of biological barriers in the body. Therefore, this review first introduces the development history of gene therapy, the current obstacles faced by gene delivery, strategies to overcome these obstacles, and conventional vectors, and then focuses on the latest research progress in various stimulus-responsive NDRS for improving gene delivery efficiency. Finally, the future challenges and prospects that stimulus-responsive NDRS may face in clinical application and transformation are discussed to provide references for enhancing in-depth research on tumor gene therapy.

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Section: Application Of Stimulus-responsive Ndrsmentioning

confidence: 99%