Highly deformable and photoresponsive smart actuators are attracting increasing attention. Here, a high concentration of graphene is dispersed in polydimethylsiloxane (PDMS) by combining the advantages of various dispersion methods. The composite and pure PDMS layers are used to fabricate bilayer actuators with a high capacity for rapid deformation. The fabricated bilayer actuators exhibit novel and interesting properties. A bilayer actuator containing a 30 wt % graphene composite can be deflected by 7.9 mm in the horizontal direction under infrared laser irradiation. The graphene concentration in the composite influences actuator adjustment to deformation and its response speed, and the composite also exhibits superhydrophobicity. On the basis of its superhydrophobicity and large deformation capacity, the actuator made with 30 wt % graphene composite is used to construct a beluga whale soft robot. The robot can swim quickly in water at an average speed of 6 mm/s, and it can cover a distance of 30 mm in 5 s when irradiated just once with an infrared laser. Actuators fabricated with this method can be used in artificial muscle, bionic grippers, and various soft robots that require actuators with large deformation capacities.
Micro/nanomotors (MNMs), which propel by transforming various forms of energy into kinetic energy, have emerged as promising therapeutic nanosystems in biomedical applications. However, most MNMs used for anticancer treatment are only powered by one engine or provide a single therapeutic strategy. Although double-engined micromotors for synergistic anticancer therapy can achieve more flexible movement and efficient treatment efficacy, their design remains challenging. In this study, we used a facile preparation method to develop enzymatic/magnetic micromotors for synergetic cancer treatment via chemotherapy and starvation therapy (ST), and the size of micromotors can be easily regulated during the synthetic process. The enzymatic reaction of glucose oxidase, which served as the chemical engine, led to self-propulsion using glucose as a fuel and ST via a reduction in the energy available to cancer cells. Moreover, the incorporation of Fe3O4 nanoparticles as a magnetic engine enhanced the kinetic power and provided control over the direction of movement. Inherent pH-responsive drug release behavior was observed owing to the acidic decomposition of drug carriers in the intracellular microenvironment of cancer cells. This system displayed enhanced anticancer efficacy owing to the synergetic therapeutic strategies and increased cellular uptake in a targeted area because of the improved motion behavior provided by the double engines. Therefore, the demonstrated micromotors are promising candidates for anticancer biomedical microsystems.
Hydrogel microstructures that encapsulate cells can be assembled into tissues and have broad applications in biology and medicine. However, 3D posture control for a single arbitrary microstructure remains a challenge. A novel 3D manipulation and assembly technique based on optothermally generated bubble robots is proposed. The generation, rate of growth, and motion of a microbubble robot can be controlled by modulating the power of a laser focused on the interface between the substrate and a fluid. In addition to 2D operations, bubble robots are able to perform 3D manipulations. The 3D properties of hydrogel microstructures are adjusted arbitrarily, and convex and concave structures with different heights are designed. Furthermore, annular micromodules are assembled into 3D constructs, including tubular and concentric constructs. A variety of hydrogel microstructures of different sizes and shapes are operated and assembled in both 2D and 3D conformations by bubble robots. The manipulation and assembly methods are simple, rapid, versatile, and can be used for fabricating tissue constructs.
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