The Influence of Type 2 Diabetes Mellitus on the Osseointegration of Titanium Implants With Different Surface Modifications—A Histomorphometric Study in High-Fat Diet/Low-Dose Streptozotocin–Treated Rats

Zhou, Wenjuan; Tangl, Stefan; Reich, Karoline Maria; Kirchweger, Franziska; Liu, Zhonghao; Zechner, Werner; Ulm, Christian; Rausch‐Fan, Xiaohui

doi:10.1097/id.0000000000000836

Cited by 16 publications

(17 citation statements)

References 38 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6 mm failed the most, trailed by implants with lengths of 11 mm and 11-12.6 mm[8]. This is consistent with the findings of Albertson et al Nevertheless, Esposito discovered that implant with a length of 11 to 12.6 mm had the highest probability of failure.…”

supporting

confidence: 88%

A Retrospective Investigation of Determining the Factors of Dental Implant Survival Rate

Kazmi¹,

Omar²,

Manzoor³

et al. 2022

PJMHS

View full text Add to dashboard Cite

Aim: Dentists have developed as both a novel potential treatment for the majority of the patients, and they are projected to play aa significant part in oral rehabilitation in future. The latest research was carried out to evaluate several parameters influencing the chance of survival of dental work. Methods: The current investigation was carried out in Services Hospital, Lahore. This study includes 5300 individuals who had dental implants implanted between June 2020 and May 2021. Individuals with hormonal imbalances, chronic infectious illnesses, immunosuppressive medication, pregnant women, drug and alcohol abusers, and suffering from chronic periodontal disorders have also been excluded. Name, age, gender, length of implant, diameter of implant, placement of implant, and biomechanical properties were among the parameters reported. Results: There were 2900 men and 2500 women among 5400 individuals. Highest implantation losses (56) were observed in patients above the age of 59 (males -560, females -740). There were 21 unsuccessful implantations in the 41-year-old age category (males 760, women 560). There were 46 unsuccessful implants in the age category 40-61 years (males -1600, women -1100). The change remained not statistically substantial (P = 0.22). Implant with a length of more than 12.6 mm (44/720) failed the most, followed by implant with a length of 11 mm (23/1670) and 11-11.6 mm (63/2870). The increase was statistical implication (P 0.06). Fasteners with just a diameter of 4.77 mm (17/1640) and implantation with a length of 5.77-3.6 mm (53/2700) failed the most (33/1050). Conclusion:The existence rate of prostheses is resolute by limitations just like age, entrenched length, diameter, bone quality, also implanted location. Researchers discovered that implants more than 12.6 mm in height and 4.76 mm in diameter, put in the mandibular posterior area of Type III bones, had the highest failure rate.

show abstract

supporting

confidence: 88%

A Retrospective Investigation of Determining the Factors of Dental Implant Survival Rate

Kazmi¹,

Omar²,

Manzoor³

et al. 2022

PJMHS

View full text Add to dashboard Cite

show abstract

“…[22][23][24][25] Some studies have investigated the osteogenesis induced by the use of these different modified Ti surfaces under the DM conditions. Zhou et al reported that, compared with mechanically polished Ti implants, implants with hydroxyapatite coating and SLA surface modification may increase bone integration in rats with type 2 DM; 26 however, other researchers have found that implants with an SLA surface had a lower boneimplant contact rate than those with SLA active surfaces under DM conditions. 27 Feng et al fabricated a honeycomblike Ti6AL4V implant designed by CAD software; they demonstrated that the osteoblasts on porous Ti surface were suppressed under DM conditions.…”

Section: In Vivo Osteogenetic Ability Of Ti Implants With Different Mmentioning

confidence: 99%

<p>TiO<sub>2</sub> Nanotubes Alleviate Diabetes-Induced Osteogenetic Inhibition</p>

Yang

Zhang

Chan

et al. 2020

IJN

View full text Add to dashboard Cite

Background: Patients with diabetes mellitus (DM) have a higher failure rate of dental implant treatments. However, whether titanium (Ti) implants with TiO 2 nanotubes (TNT) surface can retain their biocompatibility and osteogenetic ability under DM conditions has not been investigated; in addition, their behavior in DM conditions is not well characterized. Materials and Methods: Pure Ti discs were surface treated into the polishing (mechanically polished, MP), sandblasted and acid-etched (SLA), and TNT groups. Scanning electron microscopy was used to examine the surface morphology. The cell adhesion and proliferation ability on different modified Ti surfaces at various glucose concentrations (5.5, 11, 16.5, and 22 mM) was detected by the CCK-8 assay. The osteogenetic ability on different modified Ti surfaces under high-glucose conditions was evaluated by alkaline phosphatase (ALP), osteopontin (OPN) immunofluorescence, Western blot, and Alizarin Red staining in vitro. Detection of cell apoptosis and intracellular reactive oxygen species (ROS) was undertaken both before and after N-acetylcysteine (NAC) treatment to assess the oxidative stress associated with different modified Ti surfaces under high-glucose conditions. An in vivo study was conducted in DM rats with different modified Ti femoral implants. The osteogenetic ability of different modified Ti implants in DM rats was assessed using a micro-CT scan. Results: High-glucose conditions inhibited cell adhesion, proliferation, and osteogenetic ability of different modified Ti surfaces. High-glucose conditions induced higher apoptosis rate and intracellular ROS level on different modified Ti surfaces; these effects were alleviated by NAC. Compared with the SLA surface, the TNT surface alleviated the osteogenetic inhibition induced by high-glucose states by reversing the overproduction of ROS in vitro. In the in vivo experiment, micro-CT scan analysis further confirmed the best osteogenetic ability of TNT surface in rats with DM. Conclusion: TNT surface modification alleviates osteogenetic inhibition induced by DM. It may provide a more favorable Ti implant surface for patients with DM.

show abstract

“…The bone-implant interface can also be investigated with micro-computed tomography (micro-CT), which enables the 3D evaluation of the bone surrounding the implants and does not preclude further assessments afterwards [31][32][33][34][35]. This method overcomes the limits of histological analysis, such as the fact that a single histological section may not be representative of the bone apposition over the whole implant [36], and the fact that it is hard to obtain serial sectioning of bony specimens containing little metal implants positioned in small animals such as mice [37][38][39] and rats [40,41].…”

Section: Introductionmentioning

confidence: 99%

An In Vivo Study in Rat Femurs of Bioactive Silicate Coatings on Titanium Dental Implants

Brunello

Biasetto

Elsayed

et al. 2020

JCM

View full text Add to dashboard Cite

Silica-based ceramics have been proposed for coating purposes to enhance dental and orthopedic titanium (Ti) implant bioactivity. The aim of this study was to investigate the influence of sphene-based bioceramic (CaO.TiO2.SiO2) coatings on implant osseointegration in vivo. Sphene coatings were obtained from preceramic polymers and nano-sized active precursors and deposited by an automatic airbrush. Twenty customized Ti implants, ten sphene-coated and ten uncoated rough implants were implanted into the proximal femurs of ten Sprague-Dawley rats. Overall, cortical and cancellous bone-to-implant contact (BIC) were determined using micro-computed tomography (micro-CT) at 14 and 28 days. Moreover, peri-implant bone healing was histologically and histomorphometrically evaluated. The white blood cell count in the synovial fluid of the knee joints, if present, was also assessed. No difference in the BIC values was observed between the sphene-coated and uncoated implants, overall and in the two bone compartments (p > 0.05). Delamination of the coating occurred in three cases. Consistently with micro-CT data, the histological evaluation revealed no differences between the two groups. In addition, no synovial fluid could be collected on the test side, thus confirming sphene biocompatibility. In conclusion, sphene coating was found to be a suitable material for biomedical applications. Further studies are needed to improve coating adhesion to the implants.

show abstract

The Influence of Type 2 Diabetes Mellitus on the Osseointegration of Titanium Implants With Different Surface Modifications—A Histomorphometric Study in High-Fat Diet/Low-Dose Streptozotocin–Treated Rats

Cited by 16 publications

References 38 publications

A Retrospective Investigation of Determining the Factors of Dental Implant Survival Rate

A Retrospective Investigation of Determining the Factors of Dental Implant Survival Rate

<p>TiO<sub>2</sub> Nanotubes Alleviate Diabetes-Induced Osteogenetic Inhibition</p>

An In Vivo Study in Rat Femurs of Bioactive Silicate Coatings on Titanium Dental Implants

Contact Info

Product

Resources

About