The influence of the ultrasonic treatment of working fluids on electrospun amorphous solid dispersions

Abstract

Based on a working fluid consisting of a poorly water-soluble drug and a pharmaceutical polymer in an organic solvent, electrospinning has been widely exploited to create a variety of amorphous solid dispersions However, there have been very few reports about how to prepare the working fluid in a reasonable manner. In this study, an investigation was conducted to determine the influences of ultrasonic fluid pretreatment on the quality of resultant ASDs fabricated from the working fluids. SEM results demonstrated that nanofiber-based amorphous solid dispersions from the treated fluids treated amorphous solid dispersions exhibited better quality than the traditional nanofibers from untreated fluids in the following aspects: 1) a straighter linear morphology; 2) a smooth surface; and 3) a more evener diameter distribution. The fabrication mechanism associated with the influences of ultrasonic treatments of working fluids on the resultant nanofibers’ quality is suggested. Although XRD and ATR–FTIR experiments clearly verified that the drug ketoprofen was homogeneously distributed all over the TASDs and the traditional nanofibers in an amorphous state regardless of the ultrasonic treatments, the in vitro dissolution tests clearly demonstrated that the TASDs had a better sustained drug release performance than the traditional nanofibers in terms of the initial release rate and the sustained release time periods.

Electrosprayed Eudragit RL100 nanoparticles with Janus polyvinylpyrrolidone patches for multiphase release of paracetamol

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Application of Electrospun Drug-Loaded Nanofibers in Cancer Therapy

“…This breakthrough enabled the creation of novel drug-loaded sheath nanofibers, which exhibited delayed quick release, prolonged slow-release, reduced tail break release, and the complete release of drug molecules. Non-spinnable liquids encompass pure solvents, surfactants, or salt solutions, significantly broadening the application scope of electrospun nanofibers [ 46 , 47 ].…”

Dual-Step Controlled Release of Berberine Hydrochloride from the Trans-Scale Hybrids of Nanofibers and Microparticles

“…These phenomena suggested that the drug BH was converted into amorphous composites in all of them after the electrospraying or electrospinning processes. An amorphous state of the drug is favorable for its dissolution and the manipulation of a certain controlled release profile from the matrices [75,76]. FTIR spectra of the raw materials (CA, PVP, and BH) and their EHDA p shown in the left part of Figure 7.…”