Application of Electrospun Drug-Loaded Nanofibers in Cancer Therapy

Abstract

In the 21st century, chemotherapy stands as a primary treatment method for prevalent diseases, yet drug resistance remains a pressing challenge. Utilizing electrospinning to support chemotherapy drugs offers sustained and controlled release methods in contrast to oral and implantable drug delivery modes, which enable localized treatment of distinct tumor types. Moreover, the core–sheath structure in electrospinning bears advantages in dual-drug loading: the core and sheath layers can carry different drugs, facilitating collaborative treatment to counter chemotherapy drug resistance. This approach minimizes patient discomfort associated with multiple-drug administration. Electrospun fibers not only transport drugs but can also integrate metal particles and targeted compounds, enabling combinations of chemotherapy with magnetic and heat therapies for comprehensive cancer treatment. This review delves into electrospinning preparation techniques and drug delivery methods tailored to various cancers, foreseeing their promising roles in cancer treatment.

Hybrid films loaded with 5-fluorouracil and Reglan for synergistic treatment of colon cancer via asynchronous dual-drug delivery

“…Effective, safe, and convenient cancer therapy remains one of the greatest concerns in many medical and clinical fields today ( Chen et al, 2022 ; Murugesan and Raman, 2022 ; Tang et al, 2022 ; Assi et al, 2023 ; Wang et al, 2023d ; Man et al, 2023 ; Meng et al, 2022 ). Numerous active ingredients have been demonstrated for their usefulness through laboratory experiments ( Yang et al, 2024a ; Duan et al, 2024 ; Zhang et al, 2024d ); meanwhile, new types of pharmaceutical excipients (particularly those based on polymers) are being developed continuously ( Lu et al, 2022 ; Shen et al, 2022 ; Ali et al, 2023 ; Yang et al, 2024b ; Zhang et al, 2024e ; Javadi and Mohsenzadeh, 2024 ; Riaz et al, 2024 ), and novel biosourced drug carriers such as exosomes are being considered for DDSs ( Agrawal et al, 2024 ; Guo et al, 2024 ). Combining the advantages of advanced techniques with those of traditional methods to create novel medical materials from these active ingredients and excipients is an evergreen interdisciplinary challenge for researchers.…”

Electrospun Polymeric Nanofibers: Current Trends in Synthesis, Surface Modification, and Biomedical Applications

“…Furthermore, it is possible to create drug-loaded nanofibers with parallel or bead topologies by electrospinning two working fluids using eccentric spinning heads. One central area of interest in controlled drug-release research is examining the relationship between fiber architectures and drug-release characteristics while creating different drug-carrying nanofibers with unique shapes using the two-layer fluid electrospinning technology …”

Electrospun Fenoprofen/Polycaprolactone @ Tranexamic Acid/Hydroxyapatite Nanofibers as Orthopedic Hemostasis Dressings

“…Figure 3a is a whole digital image of the homemade electrospinning apparatus, in which the spinneret was set up above the fiber collector. In the literature, many electrospinning apparatuses are arranged in a horizontal manner [17,83,84], which has few influences on the working processes and the resultant nanofibers. The connections of the spinneret with the two syringe pumps and the power supply are exhibited in Figure 3b.…”

“…Their reasonable applications have been demonstrated to be able to promote hemostatic control of orthopedic surgery, improve surgical outcomes, and have the effect of promoting bone healing and reducing the appearance of complications after orthopedic surgery [15]. Among all types of nanotechnologies and nanomaterials, electrospinning and electrospun nanofibers are very special due to the single-step top-down fabrication process and the unique properties of the resultant fibrous mats [16][17][18][19]. These properties include high specific surface area and porosity [20,21], 3D web structure, and facile to be modified [22][23][24][25].…”