Electrosprayed Eudragit RL100 nanoparticles with Janus polyvinylpyrrolidone patches for multiphase release of paracetamol

Zhou, Jianfeng; Pan, Hao; Gong, Wenjian; Yu, Deng-Guang; Sun, Yuhao

doi:10.1039/d4nr00893f

Cited by 22 publications

(9 citation statements)

References 90 publications

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“…As a special applied eld, wound dressing is able to always rely on the appearances of new electrospinning techniques, [202][203][204][205][206] and also its combinations with electrospraying and other traditional chemical and physical methods. [207][208][209][210][211][212][213][214][215][216][217]…”

Section: Discussionmentioning

confidence: 99%

Recent progress of electrospun nanofibers as burning dressings

Zhang,

Yang,

Gong

et al. 2024

RSC Adv.

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Section: Discussionmentioning

confidence: 99%

Recent progress of electrospun nanofibers as burning dressings

Zhang,

Yang,

Gong

et al. 2024

RSC Adv.

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“…Reasonable selections and combinations of the starting components are very important for developing functional nanoproducts [10][11][12][13][14]. As a hemostatic medicine recommended by the World Health Organization (WHO), tranexamic acid (TA) can be used as an antifibrinolytic agent [57,58].…”

Section: Selections Of Raw Components For Fabricating the Orthopedic ...mentioning

confidence: 99%

“…In this nano era, nanotechnologies and the related nanomaterials have demonstrated their powers in almost all the applied scientific fields [6,7], including numerous biomedical treatments [8][9][10][11][12][13][14]. Those nano-related elements are bringing out revolutionary changes in the field of orthopedics for orthopedic surgery.…”

Section: Introductionmentioning

confidence: 99%

Electrospun Fenoprofen/Polycaprolactone @ Tranexamic Acid/Hydroxyapatite Nanofibers as Orthopedic Hemostasis Dressings

Huang,

Wang,

et al. 2024

Nanomaterials

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Dressings with multiple functional performances (such as hemostasis, promoting regeneration, analgesia, and anti-inflammatory effects) are highly desired in orthopedic surgery. Herein, several new kinds of medicated nanofibers loaded with several active ingredients for providing multiple functions were prepared using the modified coaxial electrospinning processes. With an electrospinnable solution composed of polycaprolactone and fenoprofen as the core working fluid, several different types of unspinnable fluids (including pure solvent, nanosuspension containing tranexamic acid and hydroxyapatite, and dilute polymeric solution comprising tranexamic acid, hydroxyapatite, and polyvinylpyrrolidone) were explored to implement the modified coaxial processes for creating the multifunctional nanofibers. Their morphologies and inner structures were assessed through scanning and transmission electron microscopes, which all showed a linear format without the discerned beads or spindles and a diameter smaller than 1.0 μm, and some of them had incomplete core–shell nanostructures, represented by the symbol @. Additionally, strange details about the sheaths’ topographies were observed, which included cracks, adhesions, and embedded nanoparticles. XRD and FTIR verified that the drugs tranexamic acid and fenoprofen presented in the nanofibers in an amorphous state, which resulted from the fine compatibility among the involved components. All the prepared samples were demonstrated to have a fine hydrophilic property and exhibited a lower water contact angle smaller than 40° in 300 ms. In vitro dissolution tests indicated that fenoprofen was released in a sustained manner over 6 h through a typical Fickian diffusion mechanism. Hemostatic tests verified that the intentional distribution of tranexamic acid on the shell sections was able to endow a rapid hemostatic effect within 60 s.

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“…As for the electrosprayed particles, they can be round spheres, dicks, shuttles and also rods or needles. They can have round smooth surface, or their surfaces can also be flattened or even recessed (Carrasco-Munoz et al, 2022;Zhou et al, 2024). The sunken particles are very common for those natural source polymers.…”

Section: The Developments Of Ehda On Creating Shapesmentioning

confidence: 99%

Engineered shapes using electrohydrodynamic atomization for an improved drug delivery

Yu,

Gong,

Zhou

et al. 2024

WIREs Nanomed Nanobiotechnol

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The shapes of micro‐ and nano‐products have profound influences on their functional performances, which has not received sufficient attention during the past several decades. Electrohydrodynamic atomization (EHDA) techniques, mainly include electrospinning and electrospraying, are facile in manipulate their products' shapes. In this review, the shapes generated using EHDA for modifying drug release profiles are reviewed. These shapes include linear nanofibers, round micro‐/nano‐particles, and beads‐on‐a‐string hybrids. They can be further divided into different kinds of sub‐shapes, and can be explored for providing the desired pulsatile release, sustained release, biphasic release, delayed release, and pH‐sensitive release. Additionally, the shapes resulted from the organizations of electrospun nanofibers are discussed for drug delivery, and the shapes and inner structures can be considered together for developing novel drug delivery systems. In future, the shapes and the related shape–performance relationships at nanoscale, besides the size, inner structure and the related structure–performance relationships, would further play their important roles in promoting the further developments of drug delivery field.This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies

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Electrosprayed Eudragit RL100 nanoparticles with Janus polyvinylpyrrolidone patches for multiphase release of paracetamol

Abstract: Advanced nanotechniques and their corresponding complex nanostructures comprise one of the most powerful tools for developing novel drug delivery systems (DDSs). In this study, a side-by-side electrospraying process was developed...

Cited by 22 publications

References 90 publications

Recent progress of electrospun nanofibers as burning dressings

Recent progress of electrospun nanofibers as burning dressings

Electrospun Fenoprofen/Polycaprolactone @ Tranexamic Acid/Hydroxyapatite Nanofibers as Orthopedic Hemostasis Dressings

Engineered shapes using electrohydrodynamic atomization for an improved drug delivery

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