The influence of long-term monosodium glutamate feeding on the structure of rats pancreas

Лeщенко, И В; Shevchuk, V H; Falalieieva, TM; Beregova, T.

doi:10.15407/fz58.02.059

Cited by 19 publications

(6 citation statements)

References 8 publications

(12 reference statements)

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“…A stock solution was prepared by dissolving 3g of MSG crystals in 100 ml of distilled water to obtain a concentration of 30 mg/ml. then, oral doses of 30mg/kg /day were given to the rats according to their weights [23] .…”

Section: Materials Usedmentioning

confidence: 99%

Evaluation Of Curcumin And Chitosan Protective Effect On Submandibular Salivary Gland Toxicity Induced By Monosodium Glutamate In Male Albino Rats

Elgamal

2021

Egyptian Dental Journal

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Monosodium glutamate is a well-known food flavor additives that is widely used all over the world but its chronic intake leads to many reported side effects. Objectives :The goal of this study was to evaluate the prophylactic role of chitosan and curcumine extract, as a well-known antioxidant, against the submandibular salivary gland (SMG) damage induced by chronic intake of monosodium glutamate (MSG).Material and methods: 36 adult male Albino rats were randomly divided into 4 groups; Group 1 (control) group, group 2 (MSG group): rats received a daily dose of MSG only by oral gavage, group 3 ( MSG + Chitosan treated group): rats received a daily dose of MSG + chitosan and finally group 4 ( MSG + curcumin treated group): rats received a daily dose of MSG + curcumin.After 6 weeks, the submandibular salivary glands were excised and processed for histological and caspase 3 immunohistochemical examination.Results: histological examination by H&E stain of group 3 and 4 revealed improvement of secretory portion architecture in addition to decreased vaculation and pleomorphism than group 2. There were a high statistical significant difference of caspase 3 immuno-expression between the treated chitosan and curcumin groups (group3 and 4) and MSG group (group 2) as p values were 0.005 and 0.017 respectively. Conclusion: administration of chitosan or curcumin has a protective effect on SMG toxicityinduced by chronic intake of MSG.

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Section: Materials Usedmentioning

confidence: 99%

Evaluation Of Curcumin And Chitosan Protective Effect On Submandibular Salivary Gland Toxicity Induced By Monosodium Glutamate In Male Albino Rats

Elgamal

2021

Egyptian Dental Journal

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“…For example, the use of Lactobacillus gasseri SBT2055 and Lactobacillus paracasei SSP paracasei F19 prevented the development of diet-induced obesity [ 27 , 28 ]. The most important cause of obesity is the excessive consumption of fat and easily digestible carbohydrates, but due to accumulated data, scientists believe that the uncontrolled use of food additives such as MSG taste enhancer can also lead to obesity [ 29 ].…”

Section: Overviewmentioning

confidence: 99%

The efficacy of probiotics for monosodium glutamate-induced obesity: dietology concerns and opportunities for prevention

et al. 2014

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IntroductionObesity becomes endemic today. Monosodium glutamate was proved as obesogenic food additive. Probiotics are discussed to impact on obesity development.Aims and objectivesThe aim was to study the effects of probiotics on the development of monosodium glutamate (MSG)-induced obesity in rats.Material and methodsWe included 45 Wistar male rats and divided into three groups (n = 15). Newborn rats of group 1 (control) received subcutaneously 8 μl/g saline. Group 2 received 3 to 4 mg/g MSG subcutaneously on the second, fourth, sixth, eighth and tenth day of life. Within 4 months after birth, rats were on a standard diet. Group 3 received an aqueous solution of probiotics mixture (2:1:1 Lactobacillus casei IMVB-7280, Bifidobacterium animalis VKL, B. animalis VKB) at the dose of 5 × 109 CFU/kg (50 mg/kg) intragastrically. Administration of probiotics was started at the age of 4 weeks just after weaning and continued for 3 months during 2-week courses. Group 2 received intragastrically 2.5 ml/kg water. Organometric and biochemical parameters in all groups of rats were analyzed over 4 months. The concentration of adiponectin was determined in serum, and leptin - in adipose tissue.ResultsAdministration of MSG led to the development of obesity in rats; body weight had increased by 7.9% vs controls (p < 0.05); body length had increased by 5.4% (p < 0.05). Body mass index and Lee index and visceral fat mass had increased (p < 0.001). Under the neonatal injection of MSG, the concentration of total cholesterol, triglycerides, VLDL cholesterol and LDL cholesterol significantly increased (p < 0.001), in comparison with controls. Adipose-derived hormones changed in MSG obesity rats: adiponectin decreased by 58.8% (p < 0.01), and leptin concentration in adipose tissue had increased by 74.7% (p < 0.01). The probiotic therapy of rats from group 3 prevented obesity development. Parameters of rats treated with probiotic mixture did not differ from that in the control.ConclusionsThe introduction of MSG to newborn rats caused the obesity in adulthood. Periodic administration of probiotic mixture to rat injected with MSG neonatally resulted in recovery of lipid metabolism and prevention of the obesity development.

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“…63 g) and SDBB (20.32±2.04 g) groups as compared to the control group (18.52±1.22). It is clear to notice that, uncontrolled use of food additives such as MSG can cause obesity (Leshchenko, et al, 2012). MSG has been utilized in several experimental models for inducing obesity which causes diabetes.…”

Section: Resultsmentioning

confidence: 99%

Amerolative Influence of Chamomile (Matricaria recutita L.) on Synthetic Food Additive Induced Probable Toxicity in Male Albino Rats التأثير المخفف للبابونج علي السمية المحتملة للمضافات الغذائية الصناعية في ذکور الجرذان البيضاء

salah-eldin

Abd-Allah

2021

Journal of Food and Dairy Sciences

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Monosodium glutamate (MSG), various organic synthetic colourants such as Sunset yellow (E110), and synthetic dye brilliant blue colouring are among the over 25,000 substances used to preserve, colour, or improve meals. Many food additives have the potential to have detrimental health effects, which makes us question about their safety. The possible adverse health effects of different food additives prompt us to doubt the safety of its widespread use. Therefore, in this study, we will use chamomile as a natural product to reduce the negative effects of these food additives. 45 male albino rats weighing 150-180 g b.wt. each, and divided into 9 equal groups, first was kept as a control-ve group, while group 2,3,4,5 were control+ve given Monosodium glutamate (MSG) from the basal diet (70 mg/kg), Sunset yellow (E110) 2mg/kg b. wt. dissolved in distilled water, and synthetic dye brilliant blue (SDBB) 2mg/kg b.wt. then give the fifth group (MSG-E110-SDBB) dissolved in distilled water daily for 56 days. The other groups (6-7-8-9) were given MSG, E110, DBB, as well as tested chamomile. Chamomile (Matricaria recutita L.) is included in the baseline diet at a rate of 5%. The effects on liver function, kidney function, Malondialdehyde (MDA), Superoxide dismutase activity (SOD), catalase (CAT), and reduced glutathione GSH, as well as histological abnormalities in the liver and brain, were then investigated. The results found that feeding with chamomile improved liver function and kidney function and other biological parameters that are after consuming food additives frequently.

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The influence of long-term monosodium glutamate feeding on the structure of rats pancreas

Cited by 19 publications

References 8 publications

Evaluation Of Curcumin And Chitosan Protective Effect On Submandibular Salivary Gland Toxicity Induced By Monosodium Glutamate In Male Albino Rats

Evaluation Of Curcumin And Chitosan Protective Effect On Submandibular Salivary Gland Toxicity Induced By Monosodium Glutamate In Male Albino Rats

The efficacy of probiotics for monosodium glutamate-induced obesity: dietology concerns and opportunities for prevention

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