Evaluation Of Curcumin And Chitosan Protective Effect On Submandibular Salivary Gland Toxicity Induced By Monosodium Glutamate In Male Albino Rats

Elgamal, Asmaa

doi:10.21608/edj.2021.55176.1426

Cited by 3 publications

(1 citation statement)

References 34 publications

(31 reference statements)

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“…Likewise, the chitosan group stained by Congo red showed a mild reaction in the periacinar and periductal areas, which was not significant compared with the control group. Our result was in agreement with a study showing the protective effect of chitosan on SSGs against the effect of monosodium glutamate, which finally showed that chitosan had a prophylactic effect against cytotoxicity formed by monosodium glutamate [ 29 ].…”

Section: Discussionsupporting

confidence: 93%

The effects of ketogenic and chitosan-based diets on submandibular salivary gland in rat model: a comparative histological study

Aboulfotoh

2024

BMC Oral Health

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Objective This study was carried out in the submandibular salivary glands (SSGs) of rats to demonstrate the effect of a ketogenic diet (KD) in comparison with dietary chitosan supplementation. Method Eighteen albino rats were randomly divided into three equal groups of six animals each. Rats in Group I were fed a balanced diet and considered controls. Meanwhile, those of Groups II and III were fed a KD, a balanced diet with high molecular weight chitosan, respectively. After 45 days, rats were euthanized, and the SSGs were dissected carefully for staining with hematoxylin and eosin (H&E), alpha-smooth muscle actin (α-SMA) immunohistochemical staining, and Congo red special stain. Quantitative data from α-SMA staining and Congo red staining were statistically analyzed using one-way ANOVA followed by Tukey’s multiple comparisons post hoc test. Results Regarding Congo red and α-SMA staining, one-way ANOVA revealed a significant difference between the three groups. For α-SMA staining and Congo red staining, Group II had the highest mean values of 91.41 ± 3.30 and 68.10 ± 5.04, respectively, while Group I had the lowest values of 56.13 ± 3.96 and 16.87 ± 2.19, respectively. Group III had mean values of 60.70 ± 3.55 for α-SMA and 19.50 ± 1.78 for Congo red. Tukey’s multiple comparisons post hoc test revealed significant differences between groups I & II and between groups II & III (P < 0.05). Meanwhile, there was a nonsignificant difference between groups I and III (P > 0.05). Conclusion A KD has a deleterious effect on rats’ SSG whatever the test we used, and dietary chitosan supplementation ameliorates these damaging effects.

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Section: Discussionsupporting

confidence: 93%

The effects of ketogenic and chitosan-based diets on submandibular salivary gland in rat model: a comparative histological study

Aboulfotoh

2024

BMC Oral Health

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Comparative Effect of Ketogenic and Chitosan-Based Diets on Submandibular Salivary Gland Morphology in Rats: A Histological and Immuno-Histochemical Analysis

Aboulfotoh

2023

Preprint

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Objective: This study was carried out in the submandibular salivary glands (SSGs) of rats to demonstrate the effect of a ketogenic diet (KD) in comparison with dietary chitosan supplementation. Method: Eighteen albino rats were randomly divided into three equal groups. Rats in Group I were fed a balanced diet and considered controls. Meanwhile, those of Groups II and III were fed a KD, a balanced diet with high molecular weight chitosan, respectively. After 45 days, rats were euthanized, and the SSGs were dissected carefully for staining with hematoxylin and eosin (H&E), alpha-smooth muscle actin (α-SMA) immunohistochemical staining, and Congo red special stain. Quantitative data from α-SMA staining and Congo red staining were statistically analyzed using one-way ANOVA followed by Tukey's multiple comparisons post hoc test. Results: Regarding Congo red and α-SMA staining, one-way ANOVA revealed a significant difference between the three groups. For α-SMA staining and Congo red staining, Group II had the highest mean values of 91.41 ± 3.30 and 68.10 ± 5.04, respectively, while Group I had the lowest values of 56.13 ± 3.96 and 16.87 ± 2.19, respectively. Group III had mean values of 60.70 ± 3.55 for α-SMA and 19.50 ± 1.78 for Congo red. Tukey's multiple comparisons post hoc test revealed significant differences between groups I & II and between groups II & III (P ˂ 0.05). Meanwhile, there was a nonsignificant difference between groups I and III (P ˃ 0.05). Conclusion: A KD has a deleterious effect on rats' SSG, and dietary chitosan supplementation ameliorates these damaging effects.

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Protective effect of rosuvastatin on cyclophosphamide-induced oral toxicity in rats: Histological and immunohistochemical Study

Mammdoh

Attarbashee

mola

2023

RJPT

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Background and Objective: Cyclophosphamide is a well-known alkylating anticancer drug that is used to treat a variety of cancers, both malignant and non-malignant. Cyclophosphamide can have a number of side effects, including oral toxicity. Rosuvastatin, a statin, has anti-inflammatory and antioxidant properties in addition to its anti-hyperlipidemic properties. The goal of this trial was to see if rosuvastatin could help prevent cyclophosphamide-induced tongue lesions. Methods: Twenty-four Wister-albino rats, weighing 300-400grams and aged 12-16 weeks, were used. The animals were divided into three groups: group I considered as control. Group 2 was given cyclophosphamide 150mg\kg and in group 3 was given cyclophosphamide 150mg/kg, and rosuvastatin (20mg/kg). The microscopic parameter was estimated, and the oxidative stress marker malondialdehyde (MDA) in the tongue was measured. On day 15, the animals (eight per group) were slaughtered, and the tongue was removed from the oral cavity for histological and immunohistochemical investigation. Results: At day 15, rosuvastatin significantly reduced the severity of the cyclophosphamide-induced tongue lesion in terms of histological score and immunohistochemistry expression of MDA (P 0.05). Conclusion: Rosuvastatin, at a dose of 20mg/kg/day, provided antioxidant and histological grade-reducing protection against cyclophosphamide-induced tongue lesion, and hence could be utilized as a preventive drug against cyclophosphamide-induced tongue lesion.

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Evaluation Of Curcumin And Chitosan Protective Effect On Submandibular Salivary Gland Toxicity Induced By Monosodium Glutamate In Male Albino Rats

Cited by 3 publications

References 34 publications

The effects of ketogenic and chitosan-based diets on submandibular salivary gland in rat model: a comparative histological study

The effects of ketogenic and chitosan-based diets on submandibular salivary gland in rat model: a comparative histological study

Comparative Effect of Ketogenic and Chitosan-Based Diets on Submandibular Salivary Gland Morphology in Rats: A Histological and Immuno-Histochemical Analysis

Protective effect of rosuvastatin on cyclophosphamide-induced oral toxicity in rats: Histological and immunohistochemical Study

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