The Influence of Lamellar Orientation on Corneal Material Behavior: Biomechanical and Structural Changes in an Avian Corneal Disorder

Boote, Craig; Elsheikh, Ahmed; Kassem, Wael; Kamma-Lorger, Christina S.; Hocking, Paul; White, Nick; Inglehearn, Chris F.; Ali, Manir; Meek, Keith Michael Andrew

doi:10.1167/iovs.10-5962

Cited by 18 publications

(16 citation statements)

References 51 publications

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“…The name Smoky Joe refers to the colour of the plumage of a line of Leghorns that inherits a sex-influenced autosomal recessive gene causing retinal degeneration and blindness [51]. The birds have varying degrees of impaired sight at hatch and are blind at 8 weeks.…”

Section: Smoky Joe (Sj)mentioning

confidence: 99%

The chick as an animal model of eye disease

Hocking

Guggenheim

2013

Drug Discovery Today: Disease Models

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A diverse range of chicken lines harbouring highly-penetrant, spontaneously-occurring mutations with an ocular phenotype have been identified over the past 40 years. These lines serve as models for human monogenic disorders including ocular albinism, retinal dystrophies such as Leber's congenital amaurosis, and coloboma, as well as the common complex traits glaucoma and myopia. Recent technical advances in gene targeting, mapping quantitative trait loci, and phenotypic characterisation of eye phenotypes offer exciting prospects for exploiting chicken genomic resources in fundamental and translational eye research. Ogiso, M. et al. (1999) Neutral and acidic glycosphingolipids in glucocorticoidinduced cataract in chick lens. Experimental Eye Research 68 (2), 229-236 76 Ritchey, E.R. et al. (2011) The chicken cornea as a model of wound healing and neuronal reinnervation. Molecular Vision 17 (264-65), 2440-2454 77 Javier, J.A.D. et al. (2006) Basement membrane and collagen deposition after laser subepithelial keratomileusis and photorefractive keratectomy in the leghorn chick eye.

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Section: Smoky Joe (Sj)mentioning

confidence: 99%

The chick as an animal model of eye disease

Hocking

Guggenheim

2013

Drug Discovery Today: Disease Models

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“…Alongside bioprinted hydrogels [3], unorganized "biopaper" scaffolds [4] have been popular due to their ease of production and ability to recapitulate biochemical cues seen in vivo by using natural polymers and a nanoporous structure. However, these systems still lack critical microarchitecture especially when creating tissue analogues of more ordered nanofibrous structures [5]. The lack of systematically organized fibrils may result in insufficient mechanical properties of these artificial tissues.…”

Section: Introductionmentioning

confidence: 99%

A Parameter Study for 3D-Printing Organized Nanofibrous Collagen Scaffolds Using Direct-Write Electrospinning

Alexander

Johnson²,

Williams

et al. 2019

Materials

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Collagen-based scaffolds are gaining more prominence in the field of tissue engineering. However, readily available collagen scaffolds either lack the rigid structure (hydrogels) and/or the organization (biopapers) seen in many organ tissues, such as the cornea and meniscus. Direct-write electrospinning is a promising potential additive manufacturing technique for constructing highly ordered fibrous scaffolds for tissue engineering and foundational studies in cellular behavior, but requires specific process parameters (voltage, relative humidity, solvent) in order to produce organized structures depending on the polymer chosen. To date, no work has been done to optimize direct-write electrospinning parameters for use with pure collagen. In this work, a custom electrospinning 3D printer was constructed to derive optimal direct write electrospinning parameters (voltage, relative humidity and acetic acid concentrations) for pure collagen. A LabVIEW program was built to automate control of the print stage. Relative humidity and electrospinning current were monitored in real-time to determine the impact on fiber morphology. Fiber orientation was analyzed via a newly defined parameter (spin quality ratio (SQR)). Finally, tensile tests were performed on electrospun fibrous mats as a proof of concept.

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“…Each cell generates a weak and short contraction pulse but collectively, it results in a strong, long and sustained contraction of the muscle and, in term, a displacement of the member. In the corneal stroma, the particular arrangement of the corneal fibroblasts (keratocytes) and ECM is essential to keep the transparency of this tissue [9][10][11][12][13]. Tendons also present a peculiar matrix alignment relative to the muscle axis.…”

Section: Introductionmentioning

confidence: 99%