The Influence of Ionic Strength and Lipid Bilayer Charge on the Stability of Liposomes

Carrión, F.J.; Maza, Alfons de la; Parra, J. L.

doi:10.1006/jcis.1994.1145

Cited by 77 publications

(52 citation statements)

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“…This behavior resembles strongly the behavior of the assemblies of amphiphilic molecules as a function of the packing parameter, while the system obeys the qualitative rules outlined by Israelachvili et al for the organic micelles [163]. The variations of the ionic force are known to influence the size and the relative stability of the liposomes and vesicles [164,165]. Independently of the exact chemical structure of the species, the main idea was that carrying out a slow polymerization reaction in a mixed solvent in the presence of an electrolyte provides the possibility for growing oligomers to produce complex patterns.…”

Section: Solution Reactionsmentioning

confidence: 79%

Synthetic approaches to the molybdenum sulfide materials

Afanasiev

2007

Comptes Rendus. Chimie

106

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Section: Solution Reactionsmentioning

confidence: 79%

Synthetic approaches to the molybdenum sulfide materials

Afanasiev

2007

Comptes Rendus. Chimie

106

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“…Binding or uptake of a compound to the phospholipid membrane of a liposome can cause changes in the electrostatic potential profile across the membrane and surface, and the changes can be evaluated through the measurement of zeta potential [27]. The zeta potential of LipoLA in deionized water determined by electrophoretic mobility measurements are summarized in Figure 2.…”

Section: Resultsmentioning

confidence: 99%

The antimicrobial activity of liposomal lauric acids against Propionibacterium acnes

et al. 2009

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This study evaluated the antimicrobial activity of lauric acid (LA) and its liposomal derivatives against Propionibacterium acnes (P. acnes), the bacterium that promotes inflammatory acne. First, the antimicrobial study of three free fatty acids (lauric acid, palmitic acid and oleic acid) demonstrated that LA gives the strongest bactericidal activity against P. acnes. However, a setback of using LA as a potential treatment for inflammatory acne is its poor water solubility. Then the LA was incorporated into a liposome formulation to aid its delivery to P. acnes. It's demonstrated that the antimicrobial activity of LA was not only well maintained in its liposomal derivatives but also enhanced at low LA concentration. In addition, the antimicrobial activity of LA-loaded liposomes (LipoLA) mainly depended on the LA loading concentration per single liposomes. Further study found that the LipoLA could fuse with the membranes of P. acnes and release the carried LA directly into the bacterial membranes, thereby killing the bacteria effectively. Since LA is a natural compound that is the main acid in coconut oil and also resides in human breast milk and liposomes have been successfully and widely applied as a drug delivery vehicle in the clinic, the LipoLA developed in this work holds great potential of becoming an innate, safe and effective therapeutic medication for acne vulgaris and other P. acnes associated diseases.

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“…5. Many detailed discussions on the effect of anionic lipid content on the zeta potential have been published (40)(41)(42). Zeta potentials have been found to have an exponential dependence on the PS content in liposomes (43).…”

Section: Effect Of Liposome Compositionmentioning

confidence: 97%

Interaction of Basic Drugs with Lipid Bilayers Using Liposome Electrokinetic Chromatography

Carrozzino

Khaledi

2004

Pharm Res

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These studies demonstrate the overall buffer ionic strength at a given pH is more important than buffer type and concentration. The interaction of positively charged drugs with charged lipid bilayer membranes is selectively influenced by the pKa of the drug. Liposomes are more biologically relevant in vitro models for cell membranes than octanol, and LEKC provides a unique combination of advantages for rapid screening of drug-membrane interactions.

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The Influence of Ionic Strength and Lipid Bilayer Charge on the Stability of Liposomes

Cited by 77 publications

References 0 publications

Synthetic approaches to the molybdenum sulfide materials

Synthetic approaches to the molybdenum sulfide materials

The antimicrobial activity of liposomal lauric acids against Propionibacterium acnes

Interaction of Basic Drugs with Lipid Bilayers Using Liposome Electrokinetic Chromatography

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