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The results of approbation of a phytopreparation for prevention and treatment of gastrointestinal disorders in calves are presented. The methodology of preclinical testing of the phytopreparation prototype was in accordance with GOST R 53434-2009 and guidelines for preclinical testing of medicines. Two groups of laboratory animals (mongrel white mice) with 10 rodents in each group aged 2-5 months were formed for preclinical study of the experimental drug according to the principle of analogs. The developed preparation (aqueous extracts of rosehip fruit – surrexit coxis, cherry fruit – cerasis fructus, chamomile flowers – pyrethri flores, amarantus rootstock – amaranthus rhizomatis) was administered to the animals in the experimental group. The dose was 3 ml/day per laboratory animal for 10 days. The feeding ration remained unchanged (grain, vegetables, hay). Positive data on physiological indices (temperature, pulse, respiration, urination, fecal condition, motor activity of animals) were obtained, which corresponded to physiological norms for white mice. The preparation has no toxicity for animal organism (absence of toxic dystrophy in animal organs); radiation level was within the normative value for cesium 137 (440 Bq/kg) and strontium 90 (110 Bq/kg), respectively; Ph was 6.7 units. The phytopreparation is a favorable environment for the gastrointestinal tract of animals and has an antibacterial effect, significantly increases the number of lymphocytes by 23.8%, hematocrit by 8.6%, hemoglobin by 40% (p < 0.01) in the blood of the experimental animals. According to the classification currently adopted by the World Health Organization, the phytopreparation can be attributed to the group of low-toxic substances and according to the degree of toxicity – to the IV class of hazard (substances of low hazard). The drug is recommended for clinical trials on young cattle.
The results of approbation of a phytopreparation for prevention and treatment of gastrointestinal disorders in calves are presented. The methodology of preclinical testing of the phytopreparation prototype was in accordance with GOST R 53434-2009 and guidelines for preclinical testing of medicines. Two groups of laboratory animals (mongrel white mice) with 10 rodents in each group aged 2-5 months were formed for preclinical study of the experimental drug according to the principle of analogs. The developed preparation (aqueous extracts of rosehip fruit – surrexit coxis, cherry fruit – cerasis fructus, chamomile flowers – pyrethri flores, amarantus rootstock – amaranthus rhizomatis) was administered to the animals in the experimental group. The dose was 3 ml/day per laboratory animal for 10 days. The feeding ration remained unchanged (grain, vegetables, hay). Positive data on physiological indices (temperature, pulse, respiration, urination, fecal condition, motor activity of animals) were obtained, which corresponded to physiological norms for white mice. The preparation has no toxicity for animal organism (absence of toxic dystrophy in animal organs); radiation level was within the normative value for cesium 137 (440 Bq/kg) and strontium 90 (110 Bq/kg), respectively; Ph was 6.7 units. The phytopreparation is a favorable environment for the gastrointestinal tract of animals and has an antibacterial effect, significantly increases the number of lymphocytes by 23.8%, hematocrit by 8.6%, hemoglobin by 40% (p < 0.01) in the blood of the experimental animals. According to the classification currently adopted by the World Health Organization, the phytopreparation can be attributed to the group of low-toxic substances and according to the degree of toxicity – to the IV class of hazard (substances of low hazard). The drug is recommended for clinical trials on young cattle.
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