The Influence of Expansion Rates on Mandibular Distraction Osteogenesis: A Computational Analysis

Boccaccio, Antonio; Pappalettere, Carmine; Kelly, Daniel J.

doi:10.1007/s10439-007-9367-x

Cited by 51 publications

(34 citation statements)

References 39 publications

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“…In addition, all three animals submitted to a bone consolidation period of 13 days, either treated with laser or not, presented relapse. These findings are in agreement with other published studies (15,16), which have recommended a bone consolidation period between 3 and 7 weeks. Our results indicate that 3 to 4 weeks are enough to guarantee some degree of bone consolidation, with no risks of relapse and no need to extend this uncomfortable part of the treatment; this recommendation is corroborated by Zheng and Cheung (17).…”

Section: Discussionsupporting

confidence: 93%

A preliminary study of hardness and modulus of elasticity in sheep mandibles submitted to distraction osteogenesis and low-level laser therapy

Freddo

Hauser

Oliveira

2011

International Journal of Oral and Maxillofacial Surgery

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Objectives: To investigate the quality of newly formed bone in sheep mandibles submitted to distraction osteogenesis and low-level laser therapy (LLLT), based on hardness and modulus of elasticity values. The ideal moment for laser application (during the latency/activation period vs. during the bone consolidation period) was also evaluated. Computed tomography imaging was used to assess relapse as a result of early device removal. Study design: Extraoral distraction devices were placed in five sheep so as to achieve 1.5 cm of lengthened bone in 60 days. Distraction devices were removed 50, 40, and 33 days after surgery. Four animals were treated with LLLT, at different times, and one was used as control (no LLLT). Results: When applied during the bone consolidation period, LLLT caused an increase in hardness and modulus of elasticity values. On the other hand, animals irradiated with LLLT during the latency/activation period presented a delay in bone healing. A period of consolidation of 13 days (early device removal) was associated with relapse. Conclusions: Nanoindentation tests were able to detect slight abnormalities in bone metabolism and proved to be important tools for the assessment of bone quality following distraction osteogenesis. LLLT provided increased benefits when applied during the bone consolidation period, once it promoted an increase in hardness and modulus of elasticity values. According to our results, the bone consolidation period should be of at least 3 weeks, so as to prevent relapse.

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Section: Discussionsupporting

confidence: 93%

A preliminary study of hardness and modulus of elasticity in sheep mandibles submitted to distraction osteogenesis and low-level laser therapy

Freddo

Hauser

Oliveira

2011

International Journal of Oral and Maxillofacial Surgery

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“…Using this mechano-regulation model (Prendergast et al, 1997), it has been possible to predict the spatial and temporal patterns of tissue differentiation during a number of regenerative events such as fracture healing Nagel and Kelly 2009), osteochondral defect repair (Kelly and Prendergast 2005;Kelly and Prendergast 2006) and distraction osteogenesis (Boccaccio et al, 2007;Boccaccio et al, 2008). However even with the use of complex computational models, it is difficult to determine how specific mechanical signals influence MSC differentiation in vivo within the milieu of other regulatory factors that are present.…”

Section: Repairmentioning

confidence: 99%

The role of mechanical signals in regulating chondrogenesis and osteogenesis of mesenchymal stem cells

Kelly

Jacobs

2010

Birth Defects Research Pt C

210

145

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It is becoming increasingly clear that Mesenchymal Stem Cell (MSC) differentiation is regulated by mechanical signals. Mechanical forces generated intrinsically within the cell in response to its extracellular environment, and extrinsic mechanical signals imposed upon the cell by the extracellular environment, play a central role in determining MSC fate. This paper reviews chondrogenesis and osteogenesis during skeletogenesis, and then considers the role of mechanics in regulating limb development and regenerative events such as fracture repair. However, observing skeletal changes under altered loading conditions can only partially explain the role of mechanics in controlling MSC differentiation. Increasingly, understanding how epigenetic factors such as the mechanical environment regulate stem cell fate is undertaken using tightly controlled in vitro models. Factors such as bio-engineered surfaces, substrates and bioreactor systems are used to control the mechanical forces imposed upon, and generated within, MSCs. From these studies, a clearer picture of how osteogenesis and chondrogenesis of MSCs is regulated by mechanical signals is beginning to emerge. Understanding the response of MSCs to such regulatory factors is a key step towards understanding their role in disease and regeneration.3

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“…This modelling has been adopted in Prendergast, 2005, 2006). Boccaccio et al (Boccaccio et al, 2007(Boccaccio et al, , 2008a, modelled the cellular dispersal by using the diffusion equation (1) however, they accounted for the fact that MSCs not only require time to differentiate, but that the differentiated cell types require time to synthesise and remodel new tissue. To this purpose, based on the results of Richardson et al (Richardson et al, 1992) who observed an exponential increase in stiffness during tibial fracture healing, they assumed that the Young's modulus of all tissues within the fracture callus increases exponentially with time.…”

Section: Mechanobiology Of Mesenchymal Stem Cellsmentioning

confidence: 99%

“…In this analysis a given displacement was imposed to the arms of the distractor. Further details about the implemented algorithm are reported in Boccaccio et al (Boccaccio et al, 2007). The spatial and temporal changes in tissue differentiation produced with these two different protocols were predicted and compared (Fig.10).…”

Section: Influence Of Expansion Rates On Mandibular Distraction Osteomentioning

confidence: 99%

Mechanobiology of Fracture Healing: Basic Principles and Applications in Orthodontics and Orthopaedics

Boccaccio¹,

Pappalettere²

2011

Theoretical Biomechanics

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The Influence of Expansion Rates on Mandibular Distraction Osteogenesis: A Computational Analysis

Cited by 51 publications

References 39 publications

A preliminary study of hardness and modulus of elasticity in sheep mandibles submitted to distraction osteogenesis and low-level laser therapy

A preliminary study of hardness and modulus of elasticity in sheep mandibles submitted to distraction osteogenesis and low-level laser therapy

The role of mechanical signals in regulating chondrogenesis and osteogenesis of mesenchymal stem cells

Mechanobiology of Fracture Healing: Basic Principles and Applications in Orthodontics and Orthopaedics

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