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Cited by 16 publications
(7 citation statements)
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“…The development of cartilage in this region can thus be explained by the influence of biophysical stimuli. Strain induces the development of fibers (and subsequently bone) whereas compression induces the formation of cartilage (Pauwels, 1960;Weinans and Prendergast, 1996;Boccaccio and Pappalettere, 2011). With functional intervertebral spaces and non-mineralized (soft) vertebral body endplates, compressive load from the vertebral body joints was likely transmitted to the non-mineralized spongy bone.…”
Section: Discussion the Primary Bone Pathology Of Dietary P Deficiencymentioning
confidence: 99%
“…The development of cartilage in this region can thus be explained by the influence of biophysical stimuli. Strain induces the development of fibers (and subsequently bone) whereas compression induces the formation of cartilage (Pauwels, 1960;Weinans and Prendergast, 1996;Boccaccio and Pappalettere, 2011). With functional intervertebral spaces and non-mineralized (soft) vertebral body endplates, compressive load from the vertebral body joints was likely transmitted to the non-mineralized spongy bone.…”
Section: Discussion the Primary Bone Pathology Of Dietary P Deficiencymentioning
confidence: 99%
“…Combined with a poroelastic FE model that predicts the strain values and fl uid fl ow acting on the differentiating cells, this mechanobiological model has successfully predicted the patterns of tissue differentiation observed experimentally around implants . Furthermore, by using a diffusion equation that describes the spreading of the cells through a fracture callus, the model has successfully simulated the time-course of fracture healing in long and irregular (Boccaccio et al , 2007(Boccaccio et al , , 2008a(Boccaccio et al , , 2008b(Boccaccio et al , , 2011a(Boccaccio et al , , 2012Boccaccio and Pappalettere, 2011) bones. In particular, assuming c to be the concentration of the mesenchymal stem cells in a given volume, D the diffusion coeffi cient and t the time variable, the spreading of cells throughout the bone callus can be described by a simple diffusion equation: (2005) to simulate the process of repair of osteochondral defects.…”
Section: Fundamentals Of Computational Mechanobiologymentioning
confidence: 98%
“…Як скінченний елемент був обраний 10-вузловий тетраедр із квадратичною апроксимацією. При обранні механічних властивостей біологічних тканин враховували той факт, що при вродженому псевдоартрозі кісткова тканина має низьку механічну міцність, на що звертали увагу при вивченні літературних джерел [9][10][11]. Для кісткового блока з автотрансплантатів обирали властивості здорової кістки [12].…”
Section: матеріали та методиunclassified