The Influence of Chronic Vitamin C Deficiency on Fatty Acid Composition of Blood Serum, Liver Triglycerides and Cholesterol Esters in Guinea Pigs

Ginter, E; Ondreicka, R; Bobek, P; Simko, V.

doi:10.1093/jn/99.3.261

Cited by 41 publications

(4 citation statements)

References 13 publications

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“…Our KEGG signaling analysis indicated that vitamin C might regulate miRNAs of thyroid hormone importance and may participate in bone metabolism. Bayerle-Eder et al (2004) reported that supplementation with vitamin C improves lipid-induced impairment of endothelium-dependent vasodilation [ 65 ] and Ginter et al (1969) demonstrated that chronic vitamin C deficiency affects the fatty acid composition of blood serum, liver triglyceride and cholesterol [ 66 ]. Fatty acids and their metabolites are important factors in stem cell proliferation and differentiation [ 67 , 68 ].…”

Section: Discussionmentioning

confidence: 99%

Modulation of miRNAs by Vitamin C in Human Bone Marrow Stromal Cells

et al. 2018

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MicroRNAs (miRNAs) are small (18–25 nucleotides), noncoding RNAs that have been identified as potential regulators of bone marrow stromal cell (BMSC) proliferation, differentiation, and musculoskeletal development. Vitamin C is known to play a vital role in such types of biological processes through various different mechanisms by altering mRNA expression. We hypothesized that vitamin C mediates these biological processes partially through miRNA regulation. We performed global miRNA expression analysis on human BMSCs following vitamin C treatment using microarrays containing human precursor and mature miRNA probes. Bioinformatics analyses were performed on differentially expressed miRNAs to identify novel target genes and signaling pathways. Our bioinformatics analysis suggested that the miRNAs may regulate multiple stem cell-specific signaling pathways such as cell adhesion molecules (CAMs), fatty acid biosynthesis and hormone signaling pathways. Furthermore, our analysis predicted novel stem cell proliferation and differentiation gene targets. The findings of the present study demonstrate that vitamin C can have positive effects on BMSCs in part by regulating miRNA expression.

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Section: Discussionmentioning

confidence: 99%

Modulation of miRNAs by Vitamin C in Human Bone Marrow Stromal Cells

et al. 2018

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“…These studies were conducted by Willis [17,18] and laid the foundation for later investigations of the effect of ascorbic acid on cholesterol metabolism [19–21]. In particular, Ginter et al recognized in a series of studies that deficiency of ascorbic acid affected the cholesterol metabolism resulting in an inverse relationship between vitamin C and the cholesterol levels in blood and liver [20,22–24]. An important aspect of this is the transformation of cholesterol to bile acids which takes place in the liver.…”

Section: Vitamin C and Dyslipidaemia In Guinea Pigsmentioning

confidence: 99%

Role of Marginal Vitamin C Deficiency in Atherogenesis: In Vivo Models and Clinical Studies

Frikke-Schmidt

Lykkesfeldt

2009

Basic Clin Pharma Tox

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“…In group IV Ascorbic Acid significantly decreased blood cholesterol which was accompanied by a mild reduction in severity of altherosclerotic lesions and deposition of stainable fat in target organs when compared to group III (Weinberger and Hayes 1999). Ginter et al (1969) reported that chronic hypovitaminosis C (2-week scorbutigenic regime followed by administration of a maintenance dose of 0.5 mg Ascorbic Acid for 24 h) in male guinea pigs produced hypercholesterolemia and an increased accumulation of cholesterol in the liver. The Ascorbic Acid deficiency significantly increased the content of saturated fatty acids ( up to length C 16 ) and decreased the content of mono-and polyunsaturated fatty acids in cholesterol esters of the liver.…”

Section: Swinementioning

confidence: 99%

Final Report of the Safety Assessment of L-Ascorbic Acid, Calcium Ascorbate, Magnesium Ascorbate, Magnesium Ascorbyl Phosphate, Sodium Ascorbate, and Sodium Ascorbyl Phosphate as Used in Cosmetics1

2005

Int J Toxicol

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L-Ascorbic Acid, Calcium Ascorbate, Magnesium Ascorbate, Magnesium Ascorbyl Phosphate, Sodium Ascorbate, and Sodium Ascorbyl Phosphate function in cosmetic formulations primarily as antioxidants. Ascorbic Acid is commonly called Vitamin C. Ascorbic Acid is used as an antioxidant and pH adjuster in a large variety of cosmetic formulations, over 3/4 of which were hair dyes and colors at concentrations between 0.3% and 0.6%. For other uses, the reported concentrations were either very low (<0.01%) or in the 5% to 10% range. Calcium Ascorbate and Magnesium Ascorbate are described as antioxidants and skin conditioning agents--miscellaneous for use in cosmetics, but are not currently used. Sodium Ascorbyl Phosphate functions as an antioxidant in cosmetic products and is used at concentrations ranging from 0.01% to 3%. Magnesium Ascorbyl Phosphate functions as an antioxidant in cosmetics and was reported being used at concentrations from 0.001% to 3%. Sodium Ascorbate also functions as an antioxidant in cosmetics at concentrations from 0.0003% to 0.3%. Related ingredients (Ascorbyl Palmitate, Ascorbyl Dipalmitate, Ascorbyl Stearate, Erythorbic Acid, and Sodium Erythorbate) have been previously reviewed by the Cosmetic Ingredient Review (CIR) Expert Panel and found "to be safe for use as cosmetic ingredients in the present practices of good use." Ascorbic Acid is a generally recognized as safe (GRAS) substance for use as a chemical preservative in foods and as a nutrient and/or dietary supplement. Calcium Ascorbate and Sodium Ascorbate are listed as GRAS substances for use as chemical preservatives. L-Ascorbic Acid is readily and reversibly oxidized to L-dehydroascorbic acid and both forms exist in equilibrium in the body. Permeation rates of Ascorbic Acid through whole and stripped mouse skin were 3.43 +/- 0.74 microg/cm(2)/h and 33.2 +/- 5.2 microg/cm(2)/h. Acute oral and parenteral studies in mice, rats, rabbits, guinea pigs, dogs, and cats demonstrated little toxicity. Ascorbic Acid and Sodium Ascorbate acted as a nitrosation inhibitor in several food and cosmetic product studies. No compound-related clinical signs or gross or microscopic pathological effects were observed in either mice, rats, or guinea pigs in short-term studies. Male guinea pigs fed a control basal diet and given up to 250 mg Ascorbic Acid orally for 20 weeks had similar hemoglobin, blood glucose, serum iron, liver iron, and liver glycogen levels compared to control values. Male and female F344/N rats and B6C3F(1) mice were fed diets containing up to 100,000 ppm Ascorbic Acid for 13 weeks with little toxicity. Chronic Ascorbic Acid feeding studies showed toxic effects at dosages above 25 mg/kg body weight (bw) in rats and guinea pigs. Groups of male and female rats given daily doses up to 2000 mg/kg bw Ascorbic Acid for 2 years had no macro- or microscopically detectable toxic lesions. Mice given Ascorbic Acid subcutaneous and intravenous daily doses (500 to 1000 mg/kg bw) for 7 days had no changes in appetite, weight gain, and general behavior; a...

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The Influence of Chronic Vitamin C Deficiency on Fatty Acid Composition of Blood Serum, Liver Triglycerides and Cholesterol Esters in Guinea Pigs

Cited by 41 publications

References 13 publications

Modulation of miRNAs by Vitamin C in Human Bone Marrow Stromal Cells

Modulation of miRNAs by Vitamin C in Human Bone Marrow Stromal Cells

Role of Marginal Vitamin C Deficiency in Atherogenesis: In Vivo Models and Clinical Studies

Final Report of the Safety Assessment of L-Ascorbic Acid, Calcium Ascorbate, Magnesium Ascorbate, Magnesium Ascorbyl Phosphate, Sodium Ascorbate, and Sodium Ascorbyl Phosphate as Used in Cosmetics1

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