The Influence of Channa Striata Extract Emulgel on Incision Wound Healing in White Rats

Abstract

Snakehead fish (Channa striata) have high albumin content, a protein needed for cell development and the formation of new tissue. The aim of this study was to determine the influence of snakehead fish extract emulgel given topically on incision wounds in white rats. The parameters of wound healing consist of wound length, a number of neutrophils, macrophages, fibroblasts and density of collagen. The white rats divide into three groups of (n = 6), one group was given the emulgel base as the negative control, one group of povidone-iodine as the positive control, and one group of snakehead fish extract 10% emulgel. White rats were sacrificed on the third and seventh days for microscopic observations. The results showed that snakehead fish extract emulgel can accelerate incision wound healing: decrease wound length, increase the number of neutrophil and macrophages cells, increase the average number of fibroblasts and increase collagen density on white rats.

Snakehead Fish Extract in Increasing Skin Collagen & Fibroblasts

“…On the third and seventh days, white mice were sacrificed for microscopic observation. Extracted snakehead fish emulgel accelerates wound healing in white mice by increasing fibroblast cells and collagen (Hendriati et al, 2019).…”

“…Combining scientific knowledge about the potential of snakehead fish with the increasing consumer need for natural and sustainable skin care, this research is an important first step in developing skin care products that are effective, environmentally friendly and based on local natural resources. In conclusion, research on extracting snakehead fish that increases collagen and skin fibroblast activity not only provides new insight into the skin health benefits of this natural ingredient but also has the potential to encourage innovation in the skin care industry for a more sustainable and beneficial future for human skin health (Hendriati et al, 2019).…”

Detection of native peptides from Channa striata extract using de novo sequencing

“…Channa striata, or snakehead and locally known as ikan gabus for Indonesian and haruan for Malaysian people, has been used for folk medicine, especially for women after giving birth and people after surgery [1,2]. Research on the ability of Channa striata water extract for wound healing instruments has been reported by Rahayu et al [3] and Hendriati et al [4]. Besides, Channa striata extract has a protective effect to inhibit cadmium-induced oxidative stress in the liver [5].…”